A5063699330- Prostate Cancer Treatment and Research
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Ultrasound and Hyperthermia Applications
- Caveolin-1 and cellular processes
- Radiation Therapy and Dosimetry
- Pancreatic and Hepatic Oncology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Medical Imaging and Pathology Studies
- Lysosomal Storage Disorders Research
- Wnt/β-catenin signaling in development and cancer
- Retinal Diseases and Treatments
- Ferroptosis and cancer prognosis
- Trypanosoma species research and implications
- Osteoarthritis Treatment and Mechanisms
- Optical Imaging and Spectroscopy Techniques
- Photoacoustic and Ultrasonic Imaging
- Cellular transport and secretion
- Cancer-related Molecular Pathways
- Ophthalmology and Visual Impairment Studies
- Corneal surgery and disorders
- Genetic and Kidney Cyst Diseases
- Glioma Diagnosis and Treatment
- Extracellular vesicles in disease
- Nerve injury and regeneration
University of Maryland, Baltimore
2016-2020
University Hospital Heidelberg
2020
Heidelberg University
2020
German Cancer Research Center
2020
Government Medical College
2020
University of Baltimore
2018
Aultman Hospital
2016
US Biologic (United States)
2007
Medical University of Vienna
2007
Mayo Clinic in Florida
2007
Abstract Intrinsic malignant brain tumors, such as glioblastomas are frequently resistant to immune checkpoint blockade (ICB) with few hypermutated showing response. Modeling patient-individual resistance is challenging due the lack of predictive biomarkers and limited accessibility tissue for serial biopsies. Here, we investigate mechanisms anti-PD-1 anti-CTLA-4 therapy in syngeneic experimental gliomas show a clear dichotomy acquired heterogeneity ICB-responder non-responder tumors. We...
Rationale: Glioblastoma is the most frequent, primary brain tumor that characterized by a highly immunosuppressive microenvironment (TME). The TME plays key role for biology and effectiveness of immunotherapies. Composition correlates with overall survival governs therapy response. Non invasive assessment has been notoriously difficult. Methods: We have designed an in vivo imaging approach to non invasively visualize innate immune cell dynamics mouse glioma model correlated MRI multiphoton...
Background: Pancreatic cancer (PC) is the fourth-most-deadly in United States with a 5-year survival rate of only 8%. Unfortunately, 10–20% PC patients are candidates for surgery, vast majority locally-advanced disease undergoing chemotherapy and/or radiation therapy (RT). Current treatments clearly inadequate and novel strategies crucially required. We investigated tripartite treatment (combination tumor targeted hyperthermia (HT), (RT), immunotherapy (IT)) to alter immunosuppressive...
Non-ablative or mild hyperthermia (HT) has been shown in preclinical (and clinical) studies as a localized radiosensitizer that enhances the tumoricidal effects of radiation. Most vivo HT use subcutaneous tumor models which do not adequately represent clinical conditions (e.g. proximity normal/critical organs) replicate microenvironment-both are important factors for eventual translation. The purpose this work is to demonstrate proof-of-concept locoregional radiosensitization with...
Three-dimensional assessment of optically cleared, entire organs and organisms has recently become possible by tissue clearing selective plane illumination microscopy ("ultramicroscopy"). Resulting datasets can be highly complex, encompass over a thousand images with millions objects data several gigabytes per acquisition. This constitutes major challenge for quantitative analysis. We have developed post-processing tools to quantify microvessels their distribution in three-dimensional from...
PURPOSE: To determine guidelines for biopsy in men with normal prostate-specific antigen (PSA) levels and suspected prostate cancer. MATERIALS AND METHODS: The clinical-sonographic features of 91 lesions reduced echogenicity 83 PSA who underwent transrectal ultrasound-guided were analyzed. RESULTS: Sixteen (19%) had cancer, two bilateral foci, four prostatic intraepithelial neoplasia (PIN). Fourteen 47 discrete hypoechoic yielded cancer or PIN versus only five 44 ill-defined vaguely (P =...