A5070451041- Tendon Structure and Treatment
- Orthopedic Surgery and Rehabilitation
- Mesenchymal stem cell research
- Osteoarthritis Treatment and Mechanisms
- Shoulder Injury and Treatment
- Knee injuries and reconstruction techniques
- Antimicrobial Peptides and Activities
- MicroRNA in disease regulation
- Spine and Intervertebral Disc Pathology
- Metabolism and Genetic Disorders
- Extracellular vesicles in disease
- Immune cells in cancer
- RNA Interference and Gene Delivery
- Product Development and Customization
- Crustacean biology and ecology
- Ureteral procedures and complications
- Open Source Software Innovations
- Blood properties and coagulation
- Peripheral Artery Disease Management
- Immunotherapy and Immune Responses
- Invertebrate Immune Response Mechanisms
- Digital Transformation in Industry
- Bioactive natural compounds
- Management and Organizational Studies
- Foot and Ankle Surgery
Nanjing Medical University
2006-2024
Jiangsu Province Hospital
2022-2024
Chinese University of Hong Kong
2020-2023
Southern Medical University
2023
McGill University
2023
Shanghai University
2022
Shanghai University of Traditional Chinese Medicine
2022
Prince of Wales Hospital
2020-2021
Chinese People's Liberation Army
2021
Lishui University
2021
Abstract Targeted drug delivery and the reduction of off‐target effects are crucial for promising clinical application nucleic acid drugs. To address this challenge, a new approach treating osteoarthritis (OA) that accurately delivers antisense oligonucleotides (ASO) targeting matrix metalloproteinase‐13 (ASO‐MMP13) to chondrocytes, is developed. Small extracellular vesicles (exos) ligated with chondrocyte affinity peptide (CAP) using Sortase A subsequently incubated cholesterol‐modified...
We analysed the genomic organisation of miR-153, a microRNA embedded in genes that encode two major type 1 diabetes autoantigens, islet-associated protein (IA)-2 and IA-2β. also identified miR-153 target correlated with IA-2β localisation function. A bioinformatics approach was used to identify miR-153's organisation. To analyse co-regulation IA-2β, quantitative PCR analysis Ia-2β (also known as Ptprn2) performed after glucose stimulation assay MIN6B cells isolated murine pancreatic islets,...
Tendon healing is a complex process involving inflammation, proliferation, and remodeling, eventually achieving state of hypocellularity hypovascularity. Currently, few treatments can satisfactorily restore the structure function native tendon. Bioactive glass (BG) has been shown to possess immunomodulatory angiogenic properties. In this study, we investigated whether an injectable hydrogel fabricated BG sodium alginate (SA) could be applied enhance tenogenesis following suture repair...
The CHCl3 extract of Matteccia orientalis showed very strong hypoglycemic activity in streptozotocin (STZ)-induced diabetic rats. A new C-methyl flavanone derivative, 2'-hydroxymatteucinol (3) was isolated from the bearing fraction, along with two known compounds, demethoxymatteucinol (1) and matteucinol (2). structures these compounds were elucidated by spectroscopic methods. One extract, (3), dose-dependent activity, a blood sugar lowering effect observed even at dose 10 mg/kg (p.o.) STZ-induced
Smart manufacturing is a key element in Industry 4.0. However, studies on the relationship between manufacturers' network structure and their technology standardization capability are not available. As such, this paper develops model to explore relationships among enterprises' structure, knowledge acquisition capability. A survey manufacturers China conducted. Hypotheses developed, structural equation modelling applied analyse model. The results indicate that three dimensions of positively...
Purpose Internet of Things (IoT), a strategic emerging industry, has brought new driving force to the global economic growth, as well an effective solution break barrier development. However, standards system IoT is not yet mature, existing obvious overlapping and even conflicting standards, enterprises lack mature technology standardization model, which severely restricts structural upgrading development IoT. The paper aims discuss these issues. Design/methodology/approach In this regard,...
Background: Acute respiratory distress syndrome (ARDS) is a severe disorder that related to high mortality.Mesenchymal stem cells (MSCs) have shown strong effects in relieving lung injury.Aims: To determine the role of umbilical cord-derived MSCs (UC-MSCs) together with surfactant protein B (SP-B) ARDS.Study Design: Animal experimentation.Methods: Immunophenotypic characteristics UC-MSCs were identified.BALB/c mice intratracheally administrated lipopolysaccharide (LPS) and received or...
Increasing reports showed that some tumor stem cells were selfrenewal and multi-lineage differentiated in tumors, similar to the normal human body. The aim of this study is observe expression cell markers lung squamous carcinoma tissues.Fifty-four cancer specimens from surgery analyzed for CK19, Notch3, CD133, P75NTR, STRO-1 ABCG2 by using S-P immunohistochemistry. In addition, ten tissue samples included as control.CK19, CD133 expressed 54 Lung tissues, without P75NTR STRO-1. rate was...
This study examines the digital translation of traditional wooden architectural construction techniques through application Building Information Modeling (BIM) methods. The development a Heritage (HBIM) model for these necessitates interdisciplinary integration. Critical steps involve intelligent incorporation knowledge into parametric models and creation advanced modeling methods capable translating such models. These aspects are essential bridging existing gaps enhancing HBIM applications....
BACKGROUND: China’s 14th Five-Year Plan for National Economic and Social Development the Long-Range Objectives Through Year 2035 clearly points out that it is necessary to implement innovation driven strategy, promote enterprise technological innovation, better play important role of entrepreneurs in innovation. Therefore, great significance explore impact entrepreneurial leadership on enterprises’ OBJECTIVE: From perspective stream, we divide ambidextrous into mainstream new stream...
Diabetic foot gangrene refers to a lesion in which the tissue of or lower extremities diabetic patients is damaged, and cause infection peripheral blood vessels neuropathy caused by diabetes.To compare related indexes glucose, inflammation, viscosity, between nonischemic ischemic foot, same different characteristics two types pathogenesis were discussed studied.A total 122 with selected from Department Vascular Medicine, Shanghai Hospital Integrated Traditional Chinese Western including 61...
Objective To investigate the effect of microRNA (miRNA)-548ah targeting histone deacetylase-4 (HDAC4) on replication and expression hepatitis B virus (HBV). Methods HepG2, 2, 15 cells were transfected by mimics inhibitors. The expressions miRNA-548ah HDAC4 before after transfection detected fluorescent quantitative polymerase chain reaction (PCR). protein in HepG2, was Western blotting. target gene analyzed bioinformatics methods. 3'UTR dual-luciferase vector containing candidate...
Journals published by Chinese Medical Association are a group of leading journals in the medical field China. To refine these journals, authors recommended that promote doubleblind peer review should be applied, supplements may omitted and supervision mechanism needs to improved. Key words: Journals Association; Standardized management; Periodical
Objective: To examine the efficacy of robot-assisted laparoscopic modified ventral onlay lingual mucosal graft for complex ureteral stricture. Methods: The clinical data 8 patients with stricture admitted to Department Urology, General Hospital Southern Theater Command from May October 2022 were retrospectively analyzed. There 6 males and 2 females, aged (45.1±10.2) years (range: 34 64 years), body mass index (24.6±2.0) kg/m2 20.7 26.6 kg/m2). Five cases on left side, 3 right length...