A5075454264- Renal Diseases and Glomerulopathies
- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Congenital Diaphragmatic Hernia Studies
- Connective Tissue Growth Factor Research
- Caveolin-1 and cellular processes
- Hormonal Regulation and Hypertension
- Lipid metabolism and disorders
- Wnt/β-catenin signaling in development and cancer
- Muscle and Compartmental Disorders
- Cytomegalovirus and herpesvirus research
- T-cell and B-cell Immunology
- Infant Health and Development
- Ovarian cancer diagnosis and treatment
- Mesenchymal stem cell research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Connective tissue disorders research
- Respiratory viral infections research
- Nitric Oxide and Endothelin Effects
- Viral Infections and Outbreaks Research
- Neonatal Respiratory Health Research
- Complement system in diseases
- Cardiovascular Syncope and Autonomic Disorders
- Cytokine Signaling Pathways and Interactions
- Renal cell carcinoma treatment
General Hospital of Central Theater Command
2023-2024
Central Hospital of Wuhan
2023
Chinese People's Liberation Army
2021
Wuhan General Hospital of Guangzhou
2006-2010
Background: Selective proteinuria is frequently observed in glomerular diseases characterized by podocyte injury.Although,1,25(OH) 2 D 3 ] has potential therapeutic effects on chronic kidney through decreasing loss, the mechanism underlying beneficial of 1,25(OH) podocytes remains still unknown.The present study tested hypothesis that directly reduced apoptosis and loss.Methods: Sprague-Dawley (SD) rats were randomly assigned into three groups: Adriamycin (ADR) group (n=15), ADR+1,25-(OH)...
Abstract Objective In this study, we investigated the development of Wnt signaling pathway in vitamin D (VitD) to improve systemic lupus erythematosus mice breakthrough clinical treatment approaches. Methods Body weight changes were recorded during rearing. Antinuclear antibodies (ANA), anti‐dsDNA, and anti‐snRNP detected mouse serum using an enzyme‐linked immunosorbent assay. Apoptosis Th1 Th2 immune cells was flow cytometry. Reverse transcription polymerase chain reaction used detect...
To investigate the role of α3β1 integrin and α/β-dystroglycan in protective effects 1,25(OH)2D3 on podocytes rats with adriamycin-induced nephropathy.Sprague-Dawley were randomly divided into three groups: control group (NC), nephropathy (NE), nephropathy+1,25(OH)2D3 (ND). Rats NE ND injected intravenously adriamycin (0.1 mg/10 g body weight) to induce nephropathy, those then subcutaneously treated for 8 weeks. Urinary protein level, number urine podocytes, foot process width...
Background: Acute respiratory distress syndrome (ARDS) is a severe disorder that related to high mortality.Mesenchymal stem cells (MSCs) have shown strong effects in relieving lung injury.Aims: To determine the role of umbilical cord-derived MSCs (UC-MSCs) together with surfactant protein B (SP-B) ARDS.Study Design: Animal experimentation.Methods: Immunophenotypic characteristics UC-MSCs were identified.BALB/c mice intratracheally administrated lipopolysaccharide (LPS) and received or...
Common primary glomerulonephritis with aberrant mucosal immunity is IgA nephropathy (IgAN). T follicular helper (TFH) cells are essential in regulating B cell differentiation. Peyer's patches (PPs) the main site where IgA+ plasmablasts differentiate.
Novel Coronavirus Pneumonia (NCP) is a class B infectious disease, which prevented and controlled according to A diseases. Recently, children′s NCP cases have gradually increased, fever outpatient department has become the first strategic pass stop epidemic. Strengthening management of diagnosis process very important for early detection suspected children, isolation, treatment prevention cross-infection. This article proposes control strategies diagnosis, optimizes processes, prevents...
Objective To test the effects of Vitamin D(VitD) on endothelial nitric oxide(NO) production and to study signal pathway leading NO release. Methods In vitro cultured human umbilical vein cells(HUVEC) were treated with various concentrations VitD(0 mmol/L, 0.01 0.10 1.00 10.00 mmol/L) for 60 min, VitD at concentration mmol/L different time points(30 90 120 min). The effect in presence receptor(VDR) agonist(ZK191784) or antagonist(ZK159222) min examined cell culture supernatant kit...
Objective To investigate the protective effect of Vitamin D (VitD) on diabetic rats, and whether mechanism is associated with expression nuclear factor kappa B (NF-κB) insulin resistance (IR). Methods Diabetic Wistar rats were established by intraperitoneal injection streptozotocin, randomly divided into group, VitD treatment group(treatment group). Normal served as normal control group.Treatment group was treated for 8 weeks.The levels 24 h urinary protein (24 UP), fasting plasma...