A5102830808- Soil Carbon and Nitrogen Dynamics
- RNA modifications and cancer
- Cancer-related gene regulation
- Esophageal Cancer Research and Treatment
- Microbial Community Ecology and Physiology
- Environmental Quality and Pollution
- Angiogenesis and VEGF in Cancer
- Soil and Water Nutrient Dynamics
- Alzheimer's disease research and treatments
- Retinal Diseases and Treatments
- Retinoids in leukemia and cellular processes
- Cancer-related Molecular Pathways
- interferon and immune responses
- Liver Disease Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Alcohol Consumption and Health Effects
- Tissue Engineering and Regenerative Medicine
- Advanced Computational Techniques and Applications
- Heavy metals in environment
- Peroxisome Proliferator-Activated Receptors
- Adsorption and biosorption for pollutant removal
- RNA Research and Splicing
- Congenital limb and hand anomalies
- Soil and Land Suitability Analysis
- Protein Tyrosine Phosphatases
Chinese Academy of Medical Sciences & Peking Union Medical College
2002-2024
Central South University
2009-2024
Affiliated Hospital of North Sichuan Medical College
2020-2024
North Sichuan Medical University
2024
Peking Union Medical College Hospital
2021-2023
Sichuan Agricultural University
2010-2022
The Affiliated Yongchuan Hospital of Chongqing Medical University
2021
Chongqing Medical University
2008-2021
Qingdao University
2020
Qingdao Municipal Hospital
2020
Abstract The presence of neuritic plaques is a pathological hallmark Alzheimer’s disease (AD). However, the origin extracellular β‐amyloid peptide (Aβ) deposits and process plaque development remain poorly understood. present study attempted to explore pathogenesis by localizing β‐secretase‐1 (BACE1) elevation relative Aβ accumulation synaptic/neuritic alterations in forebrain, using transgenic mice harboring familial AD (FAD) mutations (5XFAD 2XFAD) as models. In animals with fully...
To evaluate the response of soil respiration to moisture, temperature, and N fertilization, estimate contribution rhizosphere total CO2 emissions, a field experiment was conducted in Fengqiu State Key Agro-Ecological Experimental Station, Henan, China. The included four treatments: bare fertilized with 150 kg ha−1 (CK), maize (Zea mays L.)-cropped soils amended 0 (N0), (N150), 250 (N250) Mean seasonal emissions CK, N0, N150, N250 treatments were estimated be 294, 598, 541, 539 g C m−2,...
Intracellular lipopolysaccharide (LPS) triggers the non-canonical inflammasome pathway, resulting in pyroptosis of innate immune cells. In addition to its well-known proinflammatory role, LPS can directly cause regression some tumors, although underlying mechanism has remained unknown. Here we show that secretoglobin(SCGB)3A2, a small protein predominantly secreted airways, chaperones cytosol through cell surface receptor syndecan-1; this leads pyroptotic death driven by caspase-11. SCGB3A2...
The mechanisms underlying the occurrence and development of esophageal squamous cell carcinoma (ESCC) remains to be elucidated. present study aims investigate roles implications IGF2BP1 overexpression in ESCC.IGF2BP1 protein expression ESCC samples was assessed by immunohistochemistry (IHC), mRNA abundance INHBA analyzed with TCGA datasets RNA situ hybridization (RISH). methylation level promoter region detected methylation-specific PCR (MSP-PCR). Cell viability, migration, invasion vivo...
Choroidal neovascularization (CNV) is the common pathological basis of irreversible visual impairment encountered in a variety chorioretinal diseases; pathogenesis its development complicated and still imperfectly understood. Recent studies indicated that delta-like ligand 4 (Dll4), one Notch family ligands might participate HIF-1α-VEGF pathway to regulate CNV angiogenesis. But little known about influence potential mechanism Dll4/Notch signals on Real-time RT-PCR, Western blotting were used...
Abstract DNA amplification is one of the mechanisms to activate genes that are implicated in neoplastic transformation and gain chromosome band 3q26 a common event squamous cell carcinomas. The aim present work was identify specific target gene from four candidates ( MDS1 , PRKCI ECT2 PIK3CA ) located on esophageal carcinomas (ESCCs). To assess prevalence copy number gains putative genes, fluorescence situ hybridization (FISH) applied 108 ESCCs 9 ESCC lines. Our data showed were more...
Traumatic brain injury (TBI) is a leading cause of cell death and disability among young adults lacks successful therapeutic strategy. The multiphasic injuries TBI severely limit the success conventional pharmacological approaches. Recent successes with transplantation stem cells in bioactive scaffolds other paradigms provide new hope for treatment TBI. In this study, we transplanted neural (0.5x105 cells/µl) cultured scaffold derived from porcine urinary bladder matrix (UBM; 4 injection...
Abstract Esophagin/SPRR3 is one of the cornified‐envelope structural precursor proteins, which expressed during epithelia cell differentiation. In 1996, another research group discovered, and our own laboratory subsequently confirmed, frequent dramatic decreased expression in esophageal squamous carcinoma (ESCC). However, role tumorigenesis epithelium remains undetermined. this study, we demonstrate that frequently downregulated ESCC. contrast, no correlations between downregulation...