Wei Chen

ORCID: 0000-0002-0665-1184
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About
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Research Areas
  • Pancreatitis Pathology and Treatment
  • Biomarkers in Disease Mechanisms
  • Phagocytosis and Immune Regulation
  • Sepsis Diagnosis and Treatment
  • Pancreatic and Hepatic Oncology Research
  • Mitochondrial Function and Pathology
  • Circadian rhythm and melatonin
  • Cystic Fibrosis Research Advances
  • Heme Oxygenase-1 and Carbon Monoxide
  • Gastrointestinal disorders and treatments
  • Lipid metabolism and disorders
  • Curcumin's Biomedical Applications
  • Neutropenia and Cancer Infections
  • Streptococcal Infections and Treatments
  • Photoreceptor and optogenetics research
  • Trauma, Hemostasis, Coagulopathy, Resuscitation
  • Neonatal and Maternal Infections
  • Hemodynamic Monitoring and Therapy
  • Respiratory Support and Mechanisms
  • Autophagy in Disease and Therapy

Beijing Shijitan Hospital
2014-2023

Capital Medical University
2014-2023

Tianjin Medical University Cancer Institute and Hospital
2019

Peking Union Medical College Hospital
2019

Chinese Academy of Medical Sciences & Peking Union Medical College
2019

Hebei General Hospital
2019

Peking University
2019

Peking University Cancer Hospital
2019

Shanghai Sixth People's Hospital
2019

Shanghai Jiao Tong University
2019

Acute pancreatitis (AP) is a kind of reversible inflammatory process the exocrine pancreas. During process, systemic syndromes are involved, which relates closely to mediators. Baicalin type flavone compound extracted from Scutellaria baicalensis Georgi and exhibits anti-inflammation effect in several cancers. In this study, baicalin displayed suppressing role on IL-1[Formula: see text], TNF[Formula: text] IL-6 both cell mice models. Necrosis was decreased treatment group got markedly lower...

10.1142/s0192415x21500087 article EN The American Journal of Chinese Medicine 2020-12-26

Aim. To investigate the characteristic of hypertriglyceridemic- (HTG-) induced pancreatitis (HTG pancreatitis). Methods. We reviewed 126 cases HTG and 168 biliary as control. Results. The group mean age was younger than group. number females a little higher males in both groups. There were 18 that recurrent 11 billiary hospitalization times 13.7 ± 2.6 11.2 2.3 days two Six patients received apheresis proportion severe AP 31.0% 26.2%, mortality 1.6% 1.2%, comorbidity diabetes mellitus (DM)...

10.1155/2016/6263095 article EN cc-by Gastroenterology Research and Practice 2016-01-01

Abstract: Cardiac reperfusion injury has been found to be associated with endoplasmic reticulum (ER) stress. Recently, p21-activated kinase 2 (Pak2) identified as a primary mediator of ER stress in chronic myocardial injury. Melatonin, biological clock–related hormone, demonstrated attenuate heart burden by modulating and mitochondrial function. The aim our study was explore whether reperfusion-induced is modulated melatonin through Pak2. Hypoxia reoxygenation (HR) used vitro mimic...

10.1097/fjc.0000000000000678 article EN Journal of Cardiovascular Pharmacology 2019-07-01

To investigate the short term predictive value of hemodynamic parameters during fluid resuscitation in patients with septic shock.Data 76 shock admitted to Department Critical Care Medicine Beijing Shijitan Hospital from January 2013 October 2014 were retrospectively analyzed. The monitored by pulse indicator continuous cardiac output ( PiCCO ), including mean arterial pressure MAP stroke volume index SVI CI global ejection fraction GEF end diastolic GEDVI intrathoracic blood ITBVI...

10.3760/cma.j.issn.2095-4352.2015.01.010 article EN PubMed 2015-01-01

Objective This consensus aims to provide evidence-based recommendations on common questions in the diagnosis and treatment of acute respiratory failure (ARF) for critically ill cancer patients.Methods We developed six clinical using PICO (Population, Intervention, Comparison, Outcome) principle critical patients with ARF. Based literature searching meta-analyses, were devised. The GRADE (Grading Recommendation Assessment, Development Evaluation) method was applied each question reach expert...

10.24920/004203 article EN Chinese Medical Sciences Journal 2019-01-01

Objective To investigate the value of inflammatory biomarkers such as procalcitonin (PCT),C-reactive protein (CRP),and endotoxin in early diagnosis bacteriemia patients infected with gram-negative bacteria.Methods A cohort 79 bacteria admitted from February 2011 to May 2013 were enrolled for retrospective study.Collected data analysis included gender,age,disease severity (APACHE Ⅱ score),bacterial isolates blood culture and other general information.The white cell (WBC),neutrophils...

10.3760/cma.j.issn.1671-0282.2014.03.015 article EN Zhonghua jizhen yixue zazhi 2014-03-10

Zedoary turmeric oil injection (ZTOI) extracted from the rhizome extract of Curcuma phaeocaulis Valeton, wenyujin Y. H. Chen et C. Ling or kwangsiensis S. G. Lee F. Liang, is widely used for treatment virus-induced upper respiratory tract infections, peptic ulcers, viral pneumonia, etc. However, it has attracted widespread attention because often causes adverse drug reactions (ADRs), including dyspnea. little known about mechanism underlying dyspnea caused by ZTOI, which limits its clinical...

10.1016/j.jep.2023.117531 article EN cc-by-nc-nd Journal of Ethnopharmacology 2023-11-30
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