A5104135620- Single-cell and spatial transcriptomics
- Artificial Intelligence in Healthcare and Education
- Ferroptosis and cancer prognosis
- CRISPR and Genetic Engineering
- Immune cells in cancer
- Advanced biosensing and bioanalysis techniques
- Cancer, Lipids, and Metabolism
- Age of Information Optimization
- Service-Oriented Architecture and Web Services
- Drug Transport and Resistance Mechanisms
- Optical properties and cooling technologies in crystalline materials
- Advanced Neural Network Applications
- Urinary Tract Infections Management
- Terahertz technology and applications
- Cancer Mechanisms and Therapy
- Semiconductor Quantum Structures and Devices
- Dendrimers and Hyperbranched Polymers
- Cancer Cells and Metastasis
- Tryptophan and brain disorders
- Gyrotron and Vacuum Electronics Research
- Epigenetics and DNA Methylation
- Perovskite Materials and Applications
- Collaboration in agile enterprises
- Insects and Parasite Interactions
- Gene expression and cancer classification
Wuhan University
2024
Shandong University of Traditional Chinese Medicine
2023-2024
Beijing Jiaotong University
2024
Chinese PLA General Hospital
2024
Zhongnan Hospital of Wuhan University
2024
Northeastern University
2024
Computer Network Information Center
2023-2024
Chinese Academy of Sciences
2023-2024
State Key Laboratory of Solidification Processing
2023
Chongqing University of Technology
2023
Abstract Deciphering universal gene regulatory mechanisms in diverse organisms holds great potential for advancing our knowledge of fundamental life processes and facilitating clinical applications. However, the traditional research paradigm primarily focuses on individual model does not integrate various cell types across species. Recent breakthroughs single-cell sequencing deep learning techniques present an unprecedented opportunity to address this challenge. In study, we built extensive...
Abstract Deciphering the universal gene regulatory mechanisms in diverse organisms holds great potential to advance our knowledge of fundamental life process and facilitate research on clinical applications. However, traditional paradigm primarily focuses individual model organisms, resulting limited collection integration complex features various cell types across species. Recent breakthroughs single-cell sequencing advancements deep learning techniques present an unprecedented opportunity...
Hepatocellular carcinoma (HCC) remains a major global health burden, and sorafenib, multi-kinase inhibitor, has shown effectiveness in the treatment of HCC is considered as first-line therapy for advanced HCC. However, response to sorafenib varies among patients, development drug resistance poses prevalent obstacle. Ferroptosis, newly characterized form cell death featured by iron-dependent lipid peroxidation, emerged critical player reaction The induction ferroptosis been augment anticancer...
Modified Biejia Jianwan (M-BJJW), a Traditional Chinese Medicine (TCM) decoction, has exhibited great potential in treating hepatocellular carcinoma (HCC). However, its underlying functional mechanism still remains unknown. The study aimed to explore the anti-hepatocarcinogenic effects of M-BJJW, specifically influence on PD-L1-mediated immune evasion hypoxic conditions, and elucidate related molecular mechanisms HCC. To investigate therapeutic efficacy M-BJJW's HCC, we employed...
Abstract The construction of reliable preclinical models is crucial for understanding the molecular mechanisms involved in gastric cancer and advancing precision medicine. Currently, existing vitro tumor often do not accurately replicate human environment are unsuitable high‐throughput therapeutic drug screening. In this study, droplet microfluidic technology employed to create novel assembloids by encapsulating patient‐derived xenograft cells patient stromal Gelatin methacryloyl...
With the rapid development of intelligent transportation systems, lane detection and traffic sign recognition have become critical technologies for achieving full autonomous driving. These offer crucial real-time insights into road conditions, with their precision resilience being paramount to safety dependability vehicles. This paper introduces an innovative method detecting recognizing multi-lane lines intersection stop using computer vision technology, which is integrated signs. In image...
Introduction:Overactive bladder (OAB) is a highly prevalent condition with limited treatment options due to poor efficacy, side effects, and patient compliance.Novel drug delivery systems that can target the wall may improve OAB therapy.Methods: We explored polydopamine (PDA)-coated lactobacillus platform as potential carrier for localized treatment.Urinary microbiome profiling was performed identify presence of in healthy groups.Lactobacillus-PDA nanoparticles were synthesized characterized...
High-quality and dopant-compensated FAPbBr 3− x Cl single crystals were demonstrated. The as-grown 2.9 0.1 prevented halide migration appreciably exhibited well-defined α-particle energy spectra of both electrons holes.
A novel design scheme of electron gun for terahertz traveling-wave tubes (TWTs) is proposed, whose beam focusing electrode (BFE) includes an outer-focusing and inner-focusing to form a beam-compressive electrostatic field. In this paper, the designed 0.22 THz TWT simulated by OPERA Charged Particle Solver. circular-cylindrical cathode with radius 0.6 mm employed in gun, which provides circular 52 mA at voltage 19.5 kV. Furthermore, simulation characterization suggests that produces high...
In this brief, a three-stage broadband cascode low noise amplifier (LNA) is proposed with transformer feedback and Darlington techniques. The first two stages use to provide low-frequency gain, the structure employed in third stage compensate for highfrequency gain. additional transmission poles introduced by increase freedom of gain tuning little effect on therefore facilitating design LNAs. To verify feasibility bandwidth expansion these structures, LNA designed fabricated 0.15-μm GaAs...
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