A5018901391- Nitric Oxide and Endothelin Effects
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Obstructive Sleep Apnea Research
- Eicosanoids and Hypertension Pharmacology
- Sleep and related disorders
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Neuroscience of respiration and sleep
- Fatty Acid Research and Health
- Respiratory Support and Mechanisms
- Cancer, Lipids, and Metabolism
- Redox biology and oxidative stress
Shanghai Jiao Tong University
2014-2019
Ruijin Hospital
2017-2019
Tongren Hospital
2019
Chronic intermittent hypoxia (IH) contributes to obstructive sleep apnea (OSA)-related cardiovascular diseases through increasing oxidative stress. It has been widely recognized that estradiol decreases the risk for disease, but estrogen replacement therapy is limited its side effects. Thioredoxin (Trx) and endogenous inhibitor, thioredoxin-interacting protein (Txnip), are associated with protective effect of in some conditions. In this study, we aimed explore whether could protect against...
Chronic intermittent hypoxia (CIH) contributes to the increased risk of cardiovascular diseases in obstructive sleep apnea (OSA). We previously reported anti-apoptotic effects estradiol (E2) on IH-exposed human umbilical vein endothelial cells (HUVECs). Herein, we employed a proteomic analysis elucidate mechanisms protective E2 under IH exposure.HUVECs were divided into three groups: control, IH, and IH+E2 group. Isobaric tags for relative absolute quantification (iTRAQ) performed compare...
Chronic intermittent hypoxia (CIH) contributes to the increased risk of cardiovascular diseases in obstructive sleep apnea (OSA) through inducing oxidative stress and increasing endothelial cell apoptosis. We previously reported anti-oxidant anti-apoptotic effects estradiol (E2) on IH-exposed human umbilical vein cells (HUVECs). In this study, we employed a proteomic analysis elucidate molecular mechanisms protective under IH exposure. HUVECs were divided into four groups: control, IH, IH+E2...