A5101737105- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Tuberculosis Research and Epidemiology
- Influenza Virus Research Studies
- Mycobacterium research and diagnosis
- Immune Response and Inflammation
- Immunodeficiency and Autoimmune Disorders
- vaccines and immunoinformatics approaches
- Respiratory viral infections research
- Retinal Diseases and Treatments
- Extracellular vesicles in disease
- Lipid metabolism and disorders
- Ocular Diseases and Behçet’s Syndrome
- Cancer-related molecular mechanisms research
- Infectious Diseases and Tuberculosis
- interferon and immune responses
- Atrial Fibrillation Management and Outcomes
- Cytokine Signaling Pathways and Interactions
- Hematopoietic Stem Cell Transplantation
- Immune responses and vaccinations
- Epigenetics and DNA Methylation
- Toxic Organic Pollutants Impact
- Bacteriophages and microbial interactions
- Pleural and Pulmonary Diseases
University of Hong Kong
2013-2025
First Affiliated Hospital of Wannan Medical College
2020-2025
Wannan Medical College
2020-2025
Chinese University of Hong Kong
2008-2025
Chinese PLA General Hospital
2020-2024
Henan Provincial People's Hospital
2013-2023
Henan University
2022-2023
Zhengzhou University
2022-2023
Putian University
2023
Zhongshan Hospital
2021-2023
Melanoma is the most aggressive type of skin cancers. Traditional chemotherapy and radiotherapy have limited effectiveness can lead to systemic side effects. Photodynamic therapy (PDT) a photoresponsive cancer based on photosensitizers generate reactive oxygen species (ROS) eradicate tumor cells. Our previous study showed that exosomes derived from human γδ-T cells (γδ-T exosomes) could control Epstein–Barr virus-associated tumors. Here, we combined PDT for targeted photoimmunotherapy by...
While few children and young adults have cross-protective antibodies to the pandemic H1N1 2009 (pdmH1N1) virus, illness remains mild. The biological reasons for these epidemiological observations are unclear. In this study, we demonstrate that bulk memory cytotoxic T lymphocytes (CTLs) established by seasonal influenza viruses from healthy individuals who not been exposed pdmH1N1 can directly lyse pdmH1N1-infected target cells produce gamma interferon (IFN-gamma) tumor necrosis factor alpha...
Influenza is an acute respiratory viral disease that transmitted in the first few days of infection. Evasion host innate immune defenses, including natural killer (NK) cells, important for virus's success as a pathogen humans and other animals. NK cells encounter influenza viruses within microenvironment infected are immunity during virus It therefore to investigate direct effects on cells. In this study, we demonstrated time directly infects replicates primary human Viral entry into was...
Influenza virus is a cause of substantial annual morbidity and mortality worldwide. The potential emergence new pandemic strain (eg, avian influenza virus) major concern. Currently available vaccines anti-influenza drugs have limited effectiveness for infections, especially strains. Therefore, there an acute need to develop alternative strategies therapy. gammadelta T cells potent antiviral activities against different viruses, but no data are concerning their activity viruses.In this study,...
There are few antiviral drugs for treating influenza, and the emergence of resistance has further limited available therapeutic options. Furthermore, antivirals not invariably effective in severe such as that caused by H5N1 viruses. Thus, there is an urgent need to develop alternative strategies. Here, we show human Vγ9Vδ2 T cells expanded aminobisphosphonate pamidronate (PAM) kill influenza virus–infected inhibit viral replication vitro. In Rag2−/−γc−/− immunodeficient mice reconstituted...
Exosomes from expanded allogeneic Vδ2-T cells kill EBV-associated tumors and promote antitumor immune responses.
Radiotherapy is the first-line treatment for patients nasopharyngeal carcinoma (NPC), but its therapeutic efficacy poor in some due to radioresistance. Adoptive T cell-based immunotherapy has also shown promise control NPC; however, antitumor may be attenuated by an immunosuppressive tumor microenvironment. Exosomes derived from γδ-T cells (γδ-T-Exos) have potent potentials. However, it remains unknown whether γδ-T-Exos synergistic effect with radiotherapy and preserve their activities...
In vivo treatment of mice with the natural killer T (NKT) cell ligand, α-galactosylceramide (αGalCer), ameliorates autoimmune diabetes and experimental encephalomyelitis (EAE) by shifting pathogenic Th1-type immune responses to nonpathogenic Th2-type responses. current study, in activation NKT cells adult NZB/W multiple injections αGalCer induced an abnormal response as compared observed nonautoimmune C57BL/6 mice. This resulted decreased serum levels IgE, increased IgG2a...
In vivo treatment of mice with the natural killer T (NKT) cell ligand, α-galactosylceramide (αGalCer), ameliorates autoimmune diabetes and experimental encephalomyelitis (EAE) by shifting pathogenic Th1-type immune responses to nonpathogenic Th2-type responses. current study, in activation NKT cells adult NZB/W multiple injections αGalCer induced an abnormal response as compared observed nonautoimmune C57BL/6 mice. This resulted decreased serum levels IgE, increased IgG2a...
ABSTRACT Natural killer (NK) cells keep viral infections under control at the early phase by directly killing infected cells. Influenza is an acute contagious respiratory disease transmitted from host-to-host in first few days of infection. The evasion host innate immune defenses including NK important for its success as a pathogen humans and animals. encounter influenza virus within microenvironment It therefore to investigate direct effects on cell activity. Recently we demonstrated that...
Pulmonary fibrosis is a chronic progressive lung disease with few treatments. Human mesenchymal stem cells (MSCs) have been shown to be beneficial in pulmonary because they immunomodulatory capacity. However, there no reliable model test the therapeutic effect of human MSCs vivo. To mimic humans, we established novel bleomycin-induced humanized mice. With this model, benefit and underlying mechanisms were investigated. In addition, relevant parameters patients examined. We demonstrate that...
A new one-pot two-step tandem synthesis of highly functionalized benzo[a]pyrano[2,3-c]phenazine derivatives via microwave-assisted multicomponent reactions 2-hydroxynaphthalene-1,4-dione, diamines, aldehydes, and malononitrile is reported. The procedures are facile, avoiding time-consuming costly syntheses, tedious workup, purifications precursors, as well protection/deprotection functional groups. method expected to find application in the combinatorial biologically active compounds, since...
γδ T cells are essential constituents of antimicrobial and antitumor defenses. We have recently reported that phosphoantigen isopentenyl pyrophosphate (IPP)-expanded human Vγ9Vδ2 participated in anti-influenza virus immunity by efficiently killing both avian influenza virus-infected monocyte-derived macrophages (MDMs) vitro. However, little is known about the noncytolytic responses trafficking program to virus. In this study, we found expressed type 1 cytokines chemokine receptors during...
CD8 hi regulatory T cells control graft-versus-host disease without inhibiting graft versus tumor or general immunity in humanized mice.
Abstract Background Diagnosing latent tuberculosis (TB) infection (LTBI) and active TB (ATB) is crucial for preventing disease progression transmission. However, current diagnostic tests have limitations in terms of accuracy sensitivity, making it challenging to diagnose these different states. Therefore, this study intends develop a promising biomarker LTBI ATB diagnosis overcome the tests. Methods We developed novel multiepitope-based (MEBDB) from region differentiation antigens using...
Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI
Bruton tyrosine kinase (Btk) is not only critical for B cell development and differentiation but also involved in the regulation of Toll-like receptor-triggered innate response macrophages. However, whether Btk natural killer (NK) function remains unknown. Here, we show that expression up-regulated during maturation activation mouse NK cells. Murine Btk(-/-) cells have decreased immune responses to TLR3 ligand, with reduced expressions IFN-γ, perforin, granzyme-B cytotoxic activity....
Inducible co-stimulator (ICOS) is a member of CD28/Cytotoxic T-lymphocyte Antigen-4 (CTLA-4) family and broadly expressed in activated CD4+ T cells induced regulatory (CD4+ iTreg). ICOS-related signal pathway could be by the interaction between ICOS its ligand (ICOSL). In our previous work, we established cost-effective system to generate novel human allo-antigen specific CD4hi Treg co-culturing their naïve precursors with allogeneic CD40-activated B vitro. Here investigate role generation...