A5012730638- Protein purification and stability
- Analytical Chemistry and Chromatography
- Advanced biosensing and bioanalysis techniques
- Molecular Sensors and Ion Detection
- Microfluidic and Capillary Electrophoresis Applications
- Sulfur Compounds in Biology
- RNA Interference and Gene Delivery
- Natural product bioactivities and synthesis
- Monoclonal and Polyclonal Antibodies Research
- Nanopore and Nanochannel Transport Studies
- Advanced Battery Technologies Research
- Click Chemistry and Applications
- Antibiotics Pharmacokinetics and Efficacy
- Nanocluster Synthesis and Applications
- Chromatography in Natural Products
- Electrochemical sensors and biosensors
- Veterinary medicine and infectious diseases
- Advanced Nanomaterials in Catalysis
- Multicomponent Synthesis of Heterocycles
- Synthesis and biological activity
- Chemical Synthesis and Analysis
- Fuel Cells and Related Materials
- Crystallization and Solubility Studies
- Catalytic C–H Functionalization Methods
- Radical Photochemical Reactions
Zhejiang University
2005-2024
Taizhou University
2016-2024
Zhejiang Energy Research Institute
2023-2024
Hohai University
2024
Liaoning University
2024
Union Hospital
2023
Huazhong University of Science and Technology
2023
Shenyang Pharmaceutical University
2022
First Affiliated Hospital of Henan University
2022
Huaibei Normal University
2018-2020
Excited state double proton transfer (ESDPT) has attracted great scientific interest because of its excellent luminescent properties.
Curcumin, the primary active ingredient in spice turmeric, was converted to reactive monofunctional derivatives (carboxylic acid/azide/alkyne). The were employed produce a 3 + 2 azide-alkyne "clicked" curcumin dimer and poly(amidoamine) (PAMAM) dendrimer-curcumin conjugate. retain biological activity are efficient for labeling dissolving amyloid fibrils. selectively destroys human neurotumor cells. synthetic methodology developed affords general strategy attaching various macromolecular scaffolds.
Viologen cations are excellent electro- and photochromic materials. They generally have no response or very low sensitivity to bases. In this paper, three compounds, 1,1′-bis(2-oxo-2-phenylethyl)-4,4′-bipyridinium (viologen) with different substituents, including H (1), Cl (2), OH (3), were synthesized. All three, especially 1 2, high base in both solution solid state air atmosphere. These viologens responsive not only bases but also solvent polarity. NMR shows became enolic then a radical,...
Nanochannel-based analytical techniques have great potential applications for nucleic acid sequencing and high sensitivity detection of biological molecules. However, the conventional solid-state nanochannel sensors is hampered by a lack effective signal amplification strategies, which has limited its utility in field chemistry. Here we selected nanochannnel modified with polyethylenimine Zr4+ combination graphene oxide as sensing platform. The high-performance sensor based upon change...
DNA methylation is catalyzed by a family of methyltransferases that play crucial roles in various biological processes. Therefore, an ultrasensitive methyltransferase assay highly desirable biomedical research and clinical diagnosis. However, conventional assays for the detection activity often involve radioactive labeling, costly equipment, laborious operation. In this study, label-free method detecting adenine (Dam) CpG (M.SssI) was developed using nanopore technique coupled with cascade...
An aspartic acid-functionalized water-soluble perylene bisimide, N,N′-di(2-succinic acid)-perylene-3,4,9,10-tetracarboxylic bisimide (PASP) was synthesized and characterized. It has absorbance maximum A0–0 A0–1 at 527 498 nm (ε ≈ 1.7 × 104 L cm–1 mol–1) respectively in pH 7.20 HEPES buffer. Two quasi-reversible redox processes with E1/2 −0.17 −0.71 V (vs Ag/AgCl) 7–12.5 aqueous solutions. PASP can react Na2S pure solution to form monoanion radical dianion species consecutively. PASP–• EPR...
Hydrogen sulfide (H2S) and biothiol molecules, such as glutathione (GSH), cysteine (Cys), homocysteine (Hcy), play an important role in biology. However, understanding the complicated relationship between H2S biothiols remains enormous challenge owing to difficulty sensing simultaneously. Therefore, development of probes for detecting is great importance biological science. In this work, we reported a novel fluorescent probe sensitive selective detection (GSH) simultaneously different buffer...
Achieving large depth-of-field super-resolution imaging deep inside samples is often hindered by unknown aberrations and overlapping molecular signals in 3D single-molecule localization microscopy. Here, we present LUNAR, a blind method that simultaneously resolves corrects for using neural-physics model. Through self-supervised learning on data without requiring prior knowledge or accurate calibration, LUNAR synergistically optimizes physical model with neural network to estimate key...
A novel and efficient visible-light-induced decarboxylative cyclization/hydrogenation cascade reaction of α-oxocarboxylic acids 2-isocyanobiaryls has been developed. Without the need any external photosensitizer, oxidant, reductant, this method offers a mild green approach for synthesis diverse alcohols in moderate to good yields. mechanism indicated that an electron donor-acceptor complex-driven decarboxylation, radical addition/cyclization, situ photochemical reduction ketones could be...
Azide-terminated poly(tert-butyl acrylate) was synthesized via atom transfer radical polymerization (ATRP). Subsequent deprotection performed to yield poly(acrylic acid) (PAA) possessing a reactive chain-end. A one-pot sequential amidation of the PAA with amine derivatives near-infrared fluorescent dye (ADS832WS) and glucose produced NIRF dye-incorporated water-soluble copolymers. End-group modifications were produce alkyne/biotin-terminated copolymers which further employed generate...
In this study, a series of triazole substituted betulin and betulinic acid derivatives was designed synthesized via click chemistry at C-30 position. Eighteen target compounds were evaluated in vitro for their antitumor activities against leukemia cell-line HL-60. Seventeen have not reported before. The cytotoxic experiment showed that most derived triazoles higher profile than acid. Among them, compound 30-[4-(4-fluorophenyl)-1H-1,2,3-triazol-1-yl] (7b) the best IC50 value (1.3 μM) HL-60...
A M ycoplasma gallisepticum– E scherichia coli mixed infection model was developed in broiler chickens, which applied to pharmacokinetics of valnemulin the present experiment. The velogenic . gallisepticum standard strain S6 rejuvenated establish animal model, and wild O78 injected as supplementary inoculum induce chronic respiratory disease chickens. evaluated based on its clinical signs, histopathological examination, bacteriological assay, serum plate agglutination test. infected chickens...
A novel and efficient method for selective synthesis of diaryl sulfoxides m-arylthio sulfones has been achieved from readily available arylsulfinic acids arenes via an unusual sulfinyl cation, providing a range structurally diverse products in good to excellent yields under mild conditions. Notably, mechanistic investigations suggested were generated cation by sequence redox reaction electrophilic aromatic substitution process.