A5000692089- Global Cancer Incidence and Screening
- Cervical Cancer and HPV Research
- Economic and Financial Impacts of Cancer
- Colorectal Cancer Screening and Detection
- Advances in Oncology and Radiotherapy
- Global Health and Surgery
- Endometrial and Cervical Cancer Treatments
- Breast Cancer Treatment Studies
- Cancer Risks and Factors
- Hepatitis B Virus Studies
- Diversity and Career in Medicine
- Vaccine Coverage and Hesitancy
- AI in cancer detection
- Cardiac, Anesthesia and Surgical Outcomes
- BRCA gene mutations in cancer
- Maternal and fetal healthcare
- Child and Adolescent Health
- Global Health Workforce Issues
- Migration, Health and Trauma
- Cancer Diagnosis and Treatment
- Viral-associated cancers and disorders
- Genital Health and Disease
- Ethics in Clinical Research
- Lymphatic System and Diseases
- Maternal and Perinatal Health Interventions
University of Washington
2019-2025
University Teaching Hospital
2017-2024
University of Cincinnati
2024
University of Cincinnati Medical Center
2008-2023
Hudson Institute
2023
John Wiley & Sons (United States)
2023
ORCID
2021-2022
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
2022
Fred Hutch Cancer Center
2022
Cancer Research Center
2022
BackgroundBreast cancer is the second leading cause of death from in women sub-Saharan Africa, yet there are few well characterised large-scale survival studies with complete follow-up data. We aimed to provide robust estimates this setting and apportion gaps.MethodsThe African Breast Cancer-Disparities Outcomes (ABC-DO) prospective cohort study was done at eight hospitals across five countries (Namibia, Nigeria, South Uganda, Zambia). prospectively recruited (aged ≥18 years) who attended...
BACKGROUND: Single-dose human papillomavirus (HPV) vaccination, if efficacious, would be tremendously advantageous, simplifying implementation and decreasing costs. METHODS: We performed a randomized, multicenter, double-blind, controlled trial of single-dose nonavalent (HPV 16/18/31/33/45/52/58/6/11 infection) or bivalent 16/18 HPV vaccination compared with meningococcal among Kenyan women 15 to 20 years age. Enrollment 6-monthly cervical swabs month 3 vaginal swab were tested for...
Cervical cancer burden is high where prophylactic vaccination and screening coverage are low. We demonstrated in a multicenter randomized, double-blind, controlled trial that single-dose human papillomavirus (HPV) had vaccine efficacy (VE) against persistent infection at 18 months Kenyan women. Here, we report findings of this through 3 years follow-up. Overall, 2,275 healthy women aged 15-20 were recruited randomly assigned to receive bivalent (n = 760), nonavalent 758) or control 757)...
Breast cancer (BC) survival rates in sub-Saharan Africa (SSA) are low part due to advanced stage at diagnosis. As one component of a study the entire journey SSA women with BC, we aimed identify shared and setting-specific drivers BC. Women newly diagnosed multicountry African Cancer-Disparities Outcomes (ABC-DO) completed baseline interview their information was extracted from medical records. Ordinal logistic regression used estimate odds ratios (OR) 95% confidence intervals (CI) for (I,...
Genetically engineered live Plasmodium falciparum sporozoites constitute a potential platform for creating consistently attenuated, genetically defined, whole-parasite vaccines against malaria through targeted gene deletions. Such attenuated parasites (GAPs) do not require attenuation by irradiation or concomitant drug treatment. We previously developed P. (Pf) GAP with deletions in P52, P36, and SAP1 genes (PfGAP3KO) demonstrated its safety immunogenicity humans. Here, we further assessed...
Most breast cancer patients in sub-Saharan Africa are diagnosed at advanced stages after prolonged symptomatic periods. In the multicountry African Breast Cancer-Disparities Outcomes cohort, we dissected diagnostic journey to inform downstaging interventions. At hospital presentation for cancer, women recalled their journey, including dates of first noticing symptoms and health-care provider (HCP) visits. Negative binomial regression models were used identify correlates length journey. Among...
Abstract We examined the geospatial dimension of delays to diagnosis breast cancer in a prospective study 1541 women newly diagnosed African Breast Cancer—Disparities Outcomes (ABC‐DO) Study. Women were recruited at treatment facilities Namibia, Nigeria, Uganda and Zambia. The baseline interview included information used generate features: urban/rural residence, travel mode facility straight‐line distances from home first‐care provider diagnostic/treatment facility, categorized into...
Low breast cancer survival in sub-Saharan Africa's young population increases the likelihood that deaths result maternal orphans, ie, children (<18 years) losing their mother.
There is an urgent need to improve breast cancer survival in sub-Saharan Africa. Geospatial barriers delay diagnosis and treatment, but their effect on these settings not well understood. We examined geospatial disparities 4-year the African Breast Cancer-Disparities Outcomes cohort. In this prospective cohort study, women (aged ≥18 years) newly diagnosed with were recruited from eight hospitals Namibia, Nigeria, South Africa, Uganda, Zambia. They reported sociodemographic information...
Accurate survival estimates are needed for guiding cancer control efforts in sub-Saharan Africa, but previous studies have been hampered by unknown biases due to excessive loss follow-up (LTFU). In the African Breast Cancer-Disparities Outcomes Study, a prospective breast cohort study, we implemented active mobile health follow-up, telephoning each woman or her next-of-kin (NOK) trimonthly on phone update information vital status. Dates of every contact with women/NOK were analyzed from...
In Zambia, more than two-thirds of female patients with breast cancer present late-stage disease, leading to high mortality rates. Most the underlying causes are associated delays in symptom recognition and diagnosis. By implementing care specialty services at primary health level, we hypothesized that some could be minimized.In March 2018, established a clinic for women symptomatic disease within 1 5 district hospitals Lusaka. The offers self-awareness education, clinical examination,...
In 2005, the Cervical Cancer Prevention Program in Zambia (CCPPZ) was implemented and has since provided cervical cancer screen-and-treat services to more than 500,000 women. By leveraging successes experiences of CCPPZ, we intended build capacity for early detection surgical treatment breast cancer.Our initiative sought care through (1) formation a advocacy alliance raise awareness, (2) creation resource-appropriate training curricula mid- high-level providers, (3) implementation within two...
Background Long delays to diagnosis is a major cause of late presentation breast diseases in sub-Saharan Africa. Aims We designed and implemented single-visit care algorithm that overcomes health system-related barriers timely diseases. Methods A multidisciplinary team Zambian healthcare experts trained mid- high-level practitioners how evaluate women for diseases, train trainers do likewise. Working collaboratively, the two teams then clinical platform provides multiple services within...