A5008853017- Cervical Cancer and HPV Research
- Global Cancer Incidence and Screening
- Hepatitis B Virus Studies
- Global Health and Surgery
- Vaccine Coverage and Hesitancy
- Viral-associated cancers and disorders
- Childhood Cancer Survivors' Quality of Life
- Global Public Health Policies and Epidemiology
- Ethics in Clinical Research
- Palliative Care and End-of-Life Issues
- Global Maternal and Child Health
- Health and Medical Research Impacts
- Genital Health and Disease
- HIV/AIDS Research and Interventions
- Reproductive tract infections research
- Global Healthcare and Medical Tourism
- Biomedical Ethics and Regulation
- Wound Healing and Treatments
- Mobile Health and mHealth Applications
- Focus Groups and Qualitative Methods
- Endometrial and Cervical Cancer Treatments
- Family Support in Illness
- Global Health and Epidemiology
- Acute Lymphoblastic Leukemia research
- Pressure Ulcer Prevention and Management
World Health Organization Regional Office for Africa
2023-2024
World Health Organization - Zimbabwe
2022-2023
Ministry of Health
2017-2022
World Health Organization - Pakistan
2022
Centre for Infectious Disease Research in Zambia
2010-2019
University of Zambia
2015-2016
University of North Carolina at Chapel Hill
2013-2016
University Teaching Hospital
2010-2016
National Centre for Infectious Diseases
2015
Background Very few efforts have been undertaken to scale-up low-cost approaches cervical cancer prevention in low-resource countries. Methods In a public sector program Zambia, nurses provided visual-inspection with acetic acid (VIA) and cryotherapy clinics co-housed HIV/AIDS programs, referred women complex lesions for histopathologic evaluation. Low-cost technological adaptations were deployed improving VIA detection, facilitating expert physician opinion, ensuring quality assurance. Key...
Groesbeck Parham and colleagues describe their Cervical Cancer Prevention Program in Zambia, which has provided services to over 58,000 women the past five years, share lessons learned from program's implementation integration with existing HIV/AIDS programs.
Introduction Sub-Saharan Africa is experiencing an epidemiological transition as the burden of NCDs overtake communicable diseases. However, it unknown what capacity and gaps exist at primary care level to address growing NCDs. This study aimed assess Zambian health system's in NCDs, using adapted WHO Essential Non Communicable Disease Interventions (WHO PEN) tool. Methodology was a cross-sectional facility survey three districts conducted from September 2017 October 2017. We defined...
In Brief Objectives. Low physician density, undercapacitated laboratory infrastructures, and limited resources are major limitations to the development implementation of widely accessible cervical cancer prevention programs in sub-Saharan Africa. Materials Methods. We developed a system operated by nonphysician health providers that used available affordable communication technology create locally adaptable sustainable public sector program Zambia, one world's poorest countries. Results....
Background In the absence of stand-alone infrastructures for delivering cervical cancer screening services, efforts are underway in sub-Saharan Africa to dovetail with ongoing vertical health initiatives like HIV/AIDS care programs. Yet, evidence demonstrating utilization prevention services such integrated programs by women general population is lacking. Methods We analyzed program operations data from Cervical Cancer Prevention Program Zambia (CCPPZ), largest public sector its kind Africa....
Abstract The problem of cervical cancer in low‐ and lower‐middle‐income countries ( LLMIC s) is both urgent important, calls for governments to move beyond pilot testing population‐based screening approaches as quickly possible. Experiences from Zambia, Bangladesh, Guatemala, Honduras, Nicaragua, where scale‐up evidence‐based strategies taking place, may help other plan large‐scale implementation. These selected modalities recommended by the WHO that are within budgetary constraints, improve...
Objectives We sought to determine the clinical performance of visual inspection with acetic acid (VIA), digital cervicography (DC), Xpert human papillomavirus (HPV), and OncoE6 for cervical cancer screening in an HIV-infected population. Materials Methods women 18 years or older were included this cross-sectional validation study conducted Lusaka, Zambia. The tests compared against a histological gold standard. calculated sensitivity, specificity, positive negative predictive values,...
Background: Cervical cancer kills more women in low-income nations than any other malignancy. A variety of research and demonstration efforts have proven the efficacy effectiveness low-cost cervical prevention methods but none routine program implementation settings developing world, particularly HIV-infected women. Methods: In our public sector Zambia, nurses conduct screening using visual inspection with acetic acid aided by digital cervicography. Women visible lesions are offered...
Globally, cervical cancer is the fourth leading cause of cancer-related death among women. Poor uptake screening services contributes to high mortality. We aimed examine frequency, predictors results, and patterns sensitisation strategies by age group in a large, programmatic cohort.We did cohort study including 11 government health facilities Lusaka, Zambia, which we reviewed routine data collected through Cervical Cancer Prevention Program Zambia (CCPPZ). Participants who underwent one...
Objective. To make a rapid assessment of the common myths and misconceptions surrounding causes cervical cancer lack screening among unscreened low-income Zambian women. Methods. We initiated door-to-door community-based initiative, led by peer educators, to inform women about existence new see-and-treat prevention program. During home visits educators posed following two questions women: 1. What do you think cancer? 2. Why haven’t been screened for The most frequent types responses gathered...
Although there is a growing literature on the clinical performance of visual inspection with acetic acid in HIV-infected women, to best our knowledge, none have studied enhanced by digital cervicography. We estimated cervicography and cytology detect cervical intraepithelial neoplasia grade 2 or worse. Sensitivity specificity were 84% [95% confidence interval (CI): 72 91) 58% (95% CI: 52 64). At high-grade squamous lesion worse cutoff for cytology, sensitivity 61% 48 72) In study, seems be...
HIV infection is associated with a higher incidence of precancerous cervical lesions and their progression to invasive cancer (ICC). Zambia global epicenter ICC, yet the overall burden pre-cancer [cervical intraepithelial neoplasia 3 (CIN3)] ICC among its positive adult female population unknown. The objective this study was determine disease women in by estimating number CIN3 ICC. We conducted cross-sectional 309 attending screening Lusaka (Zambia's most populated province) measure visual...
Cervical cancer screening efforts linked to HIV/AIDS care programs are being expanded across sub-Saharan Africa. Evidence on the age distribution and determinants of invasive cervical (ICC) cases detected in such is limited.We analyzed program operations data from Cancer Prevention Program Zambia, largest public sector its kind We examined patterns by HIV serostatus histologically confirmed ICC used multivariable logistic regression evaluate independent risk factors for among younger (≤35...
Background-In Zambia, a country with generalized HIV epidemic, age-adjusted cervical cancer incidence is among the highest worldwide.In 2006, UAB-Center for Infectious Disease Research in Zambia and Zambian Ministry of Health launched visual inspection acetic acid (VIA)-based "see treat" prevention program Lusaka.All services were integrated within existing government-operated primary health care facilities.Objective-Study aims to: 1) identify women's motivations screening; 2) document...
In Zambia, more than two-thirds of female patients with breast cancer present late-stage disease, leading to high mortality rates. Most the underlying causes are associated delays in symptom recognition and diagnosis. By implementing care specialty services at primary health level, we hypothesized that some could be minimized.In March 2018, established a clinic for women symptomatic disease within 1 5 district hospitals Lusaka. The offers self-awareness education, clinical examination,...
Health sector priorities and interventions to prevent manage noncommunicable diseases injuries (NCDIs) in low- lower-middle-income countries (LLMICs) have primarily adopted elements of the World Organization Global Action Plan for NCDs 2013-2020. However, there been limited efforts LLMICs prioritize among conditions health-sector NCDIs based on local epidemiology contextually relevant risk factors or that incorporate equitable distribution health outcomes. The Lancet Commission Reframing...
We examined age, residence, education and wealth inequalities their combinations on cervical precancer screening probabilities for women. hypothesised that in favoured women who were older, lived urban areas, more educated wealthier. Cross-sectional study using Population-Based HIV Impact Assessment data. Ethiopia, Malawi, Rwanda, Tanzania, Zambia Zimbabwe. Differences rates analysed multivariable logistic regressions, controlling wealth. Inequalities probability estimated marginal effects...
Cancer is a major public health concern, impacting nearly 20 million people each year, and it responsible for 1 in 6 deaths worldwide. The burden of cancer increasing rapidly, straining systems that are unable to prevent manage the disease. Childhood constitutes significant relevant challenge; was ninth leading cause childhood disease globally, according findings by Global Burden Disease 2017 study. Almost 80% all children diagnosed with live low- middle-income countries where treatment...
The Cervical Cancer Prevention Program in Zambia (CCPPZ) has increasingly used community-level structures to increase the uptake and ensure sustainability of program. Traditional marriage counselors, alangizi, who have existed Zambian society for many years, are one by program impart cervical cancer knowledge access screening care using an existing community structure. Several steps were followed developing this intervention: (a) ensuring alangizi understood process encouraging them go...