A5003190149- Global Cancer Incidence and Screening
- Colorectal Cancer Screening and Detection
- Multiple and Secondary Primary Cancers
- Health Systems, Economic Evaluations, Quality of Life
- Economic and Financial Impacts of Cancer
- Statistical Methods and Bayesian Inference
- Genetic factors in colorectal cancer
- Statistical Methods and Inference
- demographic modeling and climate adaptation
- Cancer and Skin Lesions
- Colorectal Cancer Surgical Treatments
- Cancer Immunotherapy and Biomarkers
- Cancer survivorship and care
- Male Breast Health Studies
- Cancer Risks and Factors
- BRCA gene mutations in cancer
- Lung Cancer Treatments and Mutations
- Esophageal Cancer Research and Treatment
- Breast Cancer Treatment Studies
- Cervical Cancer and HPV Research
- Patient-Provider Communication in Healthcare
- Ocular Diseases and Behçet’s Syndrome
- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Pancreatic and Hepatic Oncology Research
London School of Hygiene & Tropical Medicine
2016-2025
Faculty of Public Health
2024
Cancer Research UK
2008-2016
University of London
2006-2015
Instituto Português de Oncologia de Coimbra Francisco Gentil
2008
Associação Paulista de Medicina
1993
Cancer survival varies widely between countries. The CONCORD study provides estimates for 1.9 million adults (aged 15-99 years) diagnosed with a first, primary, invasive cancer of the breast (women), colon, rectum, or prostate during 1990-94 and followed up to 1999, by use individual tumour records from 101 population-based registries in 31 countries on five continents. This is, our knowledge, first worldwide analysis survival, standard quality-control procedures identical analytic methods...
Assessment of progress in cancer control at the population level is increasingly important. Population-based survival trends provide a key insight into overall effectiveness health system, alongside incidence and mortality. For this purpose, we aimed to unique measure survival.
BackgroundBreast cancer is the second leading cause of death from in women sub-Saharan Africa, yet there are few well characterised large-scale survival studies with complete follow-up data. We aimed to provide robust estimates this setting and apportion gaps.MethodsThe African Breast Cancer-Disparities Outcomes (ABC-DO) prospective cohort study was done at eight hospitals across five countries (Namibia, Nigeria, South Uganda, Zambia). prospectively recruited (aged ≥18 years) who attended...
BackgroundThe National Health Service (NHS) cancer plan for England was published in 2000, with the aim of improving survival patients cancer. By contrast, a formal strategy not implemented Wales until late 2006. data on patient and up to 2007 thus offer opportunity first assessment England, by comparing trends those before, during, after implementation plan.MethodsWe analysed population-based 2·2 million adults diagnosed one 21 common cancers during 1996–2006 followed Dec 31, 2007. We...
Socioeconomic inequalities in survival were observed for many cancers England during 1981–1999. The NHS Cancer Plan (2000) aimed to improve and reduce these inequalities. This study examines trends the deprivation gap cancer after implementation of Plan. We examined relative among adults diagnosed with 1 21 common 1996–2006, followed up 31 December 2007. Three periods defined: 1996–2000 (before Plan), 2001–2003 (initialisation) 2004–2006 (implementation). estimated difference between most...
Campaigns aimed at raising cancer awareness and encouraging early presentation have been implemented in England. However, little is known about whether people with low increased barriers to seeking medical help worse survival, there a geographical variation From population-based surveys (n=35 308), using the Cancer Research UK Awareness Measure, we calculated age- sex-standardised symptom scores for 52 primary care trusts (PCTs). These measures were evaluated relation sex-, age-, type of...
Introduction We investigated socioeconomic disparities and the role of main prognostic factors in receiving major surgical treatment patients with lung cancer England. Methods Our study comprised 31 351 diagnosed non-small cell England 2012. Data from national population-based registry were linked to Hospital Episode Statistics National Lung Cancer Audit data obtain information on stage, performance status comorbidities, identify treatment. To describe association between surgery, we...
The introduction of immune checkpoint inhibitors (ICIs) has modified treatment modalities for patients with lung cancer, offering new alternatives treatment. Despite improved survival benefits, ICIs may cause side effects impacting patients' quality life (QoL). We aim to study the changes in global QoL (gQoL) advanced-stage cancer up 18 months after between 2015 and 2021. A longitudinal cohort was conducted using Oncological Life Study: Living well as a survivor data-biobank from University...
Objectives There is limited evidence regarding the impact of race/racism and its intersection with socioeconomic status (SES) on breast cervical cancer, two most common female cancers globally. We investigated racial inequalities in cancer mortality whether SES (education household conditions) interacted race/ethnicity.Design The 100 Million Brazilian Cohort data were linked to Mortality Database, 2004–2015 (n = 20,665,005 adult women). analysed association between self-reported...
Variation in colon cancer mortality occurring shortly after diagnosis is widely reported between socio-economic status (SES) groups: we investigated the role of different prognostic factors explaining variation 90-day mortality. National registry data were linked with national clinical audit and Hospital Episode Statistics records for 69 769 adults diagnosed England January 2010 March 2013. By gender, logistic regression was used to estimate effects SES, age stage at diagnosis, comorbidity...
Non-small cell lung cancer (NSCLC) comprises approximately 85% of all cases, and surgery is the preferred treatment for patients. The National Health Service established Primary Care Trusts (PCTs) in 2002 to manage local health needs. We investigate whether PCTs with a lower uptake surgical are those above-average mortality 1 year after diagnosis. applied methods can be used monitor performance any administrative bodies responsible management patients cancer.
Background The CONCORD study compares population-based relative survival from cancer using data registries in five continents. To estimate survival, general mortality life tables are required. Available statistics incomplete, so various approaches used to construct complete tables. This article outlines how the were constructed for CONCORD; it expectancy at birth between 101 populations covered by 31 countries and impact of two deployment analysis. Methods approach, specific mathematical...
Despite the well-established function of prolactin (PRL) in normal breast development, its role cancer pathogenesis is still controversial. PRL activity dependent on activation a transmembrane protein, receptor (PRLR). The aim was to evaluate and compare PRLR expression gynaecomastia male carcinoma (MBC).PRLR detected immunohistochemically 30 cases MBC. whole series also assessed for oestrogen receptors (ER), progesterone (PR) androgen (AR). A cut-off 10% used as criterion positivity....
Funnel plots are graphical tools designed to detect excessive variation in performance indicators by simple visual inspection of the data. Their main use biomedical domain so far has been publication bias meta-analyses, but they have also recommended as most appropriate way display for a vast range health-related outcomes. Here, we extend funnel population-based cancer survival and several related measures. We present three applications familiarise reader with their interpretation. propose...
<h3>Background</h3> Reducing geographical inequalities in cancer survival England was a key aim of the Calman–Hine Report (1995) and NHS Cancer Plan (2000). This study assesses whether changed following these policy developments by analysing trend 1-year relative 28 networks England. <h3>Methods</h3> Population-based age-standardised at 1 year is estimated for 1.4 million patients diagnosed with oesophagus, stomach, colon, lung, breast (women) or cervix during 1991–2006 followed up to 2007....
<i>Aim:</i> The purpose of this study was to compare the immunohistochemical profile cell cycle inhibitors G1/S phase transition (p21, p53 and pRb), Ki-67 proliferation marker DNA ploidy in male (MBC) female breast cancer (FBC). <i>Material Methods:</i> One hundred patients (50 non-consecutive cases FBC an equal number MBC) were selected according homogeneous features regarding age, histological type, tumour grading, nodal status absence neoadjuvant therapy....
Abstract Excess hazard modelling is one of the main tools in population-based cancer survival research. Indeed, this setting allows for direct due to even absence reliable information on cause death, which common epidemiology studies. We propose a unifying link-based additive framework excess that inclusion many types covariate effects, including spatial and time-dependent using any type smoother, such as thin plate, cubic splines, tensor products Markov random fields. In addition, accounts...
In population-based cancer research, piecewise exponential regression models are used to derive adjusted estimates of excess mortality due using the Poisson generalized linear modelling framework. However, assumption that conditional mean and variance rate parameter given set covariates x i equal is strong may fail account for overdispersion variability (the exceeds mean). Using an empirical example, we aimed describe simple methods test correct overdispersion. We a regression-based score...
Background Despite persistent reports of socioeconomic inequalities in colorectal cancer survival England, the magnitude differences has not been fully evaluated. Methods Patients diagnosed with colon (n=68 169) and rectal (n=38 267) England (diagnosed between January 2010 March 2013) were analysed as a retrospective cohort study using National Cancer Registry data linked other population-based healthcare records. The flexible parametric model incorporating time-varying covariates was used...
Abstract Background Individual and tumour factors only explain part of observed inequalities in colorectal cancer survival England. This study aims to investigate treatment patients with cancer. Methods All diagnosed England between 2012 2016 were followed up from the date diagnosis (state 1), 2), death 3) or censored at 1 year after diagnosis. A multistate approach flexible parametric model was used effect income deprivation on probability remaining alive treated Results Compared least...
Excess hazard models became the preferred modelling tool in population-based cancer survival research. In this setting, model is commonly formulated as additive decomposition of overall into two components: excess due to interest and population all other causes death. We introduce a flexible Bayesian regression for log-excess where baseline any non-linear effects covariates are modelled using low-rank thin plate splines. Using type splines will ensure that log-likelihood function retains...
Relative survival represents the preferred framework for analysis of population cancer data. The aim is to model probability associated with in absence information about cause death. Recent data linkage developments have allowed incorporating place residence into databases; however, modeling this spatial has received little attention relative setting. We propose a flexible parametric class excess hazard models (along inference tools), named "Relative Survival Spatial General Hazard," that...
Abstract Background Introduction of immune checkpoint inhibitors (ICIs) has modified treatment modalities for patients with lung cancer, offering new alternatives treatment. Despite improved survival benefits, ICIs may cause side-effects impacting patients’ quality life (QoL). We aim to study the changes in global QoL (gQoL) up 18 months advanced stage cancer after between 2015-2021. Methods and Analysis A longitudinal cohort was conducted using OncoLifeS data-biobank from University Medical...