A5044391431- Congenital gastrointestinal and neural anomalies
- Big Data and Business Intelligence
- BRCA gene mutations in cancer
- Research Data Management Practices
- Data Quality and Management
- Digestive system and related health
- Ovarian cancer diagnosis and treatment
- Neurogenesis and neuroplasticity mechanisms
- Competitive and Knowledge Intelligence
- Gastrointestinal motility and disorders
- Cancer-related Molecular Pathways
- Congenital heart defects research
- HER2/EGFR in Cancer Research
- Cutaneous lymphoproliferative disorders research
- Genomic variations and chromosomal abnormalities
- Male Breast Health Studies
- Cancer Genomics and Diagnostics
- Microtubule and mitosis dynamics
- T-cell and Retrovirus Studies
- Genetic factors in colorectal cancer
- Pluripotent Stem Cells Research
- Developmental Biology and Gene Regulation
- Diet and metabolism studies
- Metastasis and carcinoma case studies
- Gastric Cancer Management and Outcomes
Fundação para a Ciência e Tecnologia
2017-2022
The Francis Crick Institute
2009-2017
Medical Research Council
2017
Instituto Gulbenkian de Ciência
2016
Centro Hospitalar do Porto
2008
Hospital de Santo António
2008
Instituto Português de Oncologia de Coimbra Francisco Gentil
2005-2007
IPO Porto
2007
The enteric nervous system (ENS) in mammals forms from neural crest cells during embryogenesis and early postnatal life. Nevertheless, multipotent progenitors of the ENS can be identified adult intestine using clonal cultures vivo transplantation assays. identity these neurogenic precursors gut their relationship to embryonic are currently unknown. Using genetic fate mapping, we here demonstrate that mouse marked by SRY box-containing gene 10 (Sox10) generate neuronal glial lineages ganglia....
Background & AimsThe enteric nervous system (ENS) regulates gastrointestinal function via different subtypes of neurons, organized into fine-tuned neural circuits. It is not clear how cell diversity created within the embryonic ENS; information required for development cell-based therapies and models neuropathies. We aimed to identify proteins that regulate ENS differentiation network formation.MethodsWe generated compared RNA expression profiles entire ENS, progenitor cells, non-ENS gut...
The generation of neurons from neural stem cells requires large-scale changes in gene expression that are controlled to a large extent by proneural transcription factors, such as Ascl1. While recent studies have characterized the differentiation genes activated less is known on mechanisms suppress progenitor cell identity. Here, we show Ascl1 induces factor MyT1 while promoting neuronal differentiation. We combined functional during neurogenesis with characterization its transcriptional...
Centrosome abnormalities are a typical hallmark of human cancers. However, the origin and dynamics such in cancer not known. In this study, we examined centrosomes Barrett’s esophagus tumorigenesis, well-characterized multistep pathway progression, from premalignant condition to metastatic disease. This model allows study sequential steps progression within same patient has representative cell lines all stages Remarkably, centrosome amplification was detected as early significantly expanded...
Only 20–25% of families screened for BRCA1/2 mutations are found positive. Because only a positive result is informative, we studied the role immunohistochemistry as an additional method patient selection. From 53 high-risk-affected probands, 18 (34%) had available paraffin blocks their tumors and were selected this study. Mutation screening was done by conformation-sensitive gel electrophoresis multiplex ligation-dependent probe amplification. For immunohistochemistry, 21 neoplastic...
<i>Aim:</i> The purpose of this study was to compare the immunohistochemical profile cell cycle inhibitors G1/S phase transition (p21, p53 and pRb), Ki-67 proliferation marker DNA ploidy in male (MBC) female breast cancer (FBC). <i>Material Methods:</i> One hundred patients (50 non-consecutive cases FBC an equal number MBC) were selected according homogeneous features regarding age, histological type, tumour grading, nodal status absence neoadjuvant therapy....
PTCRIS (Portuguese Current Research Information System - https://ptcris.pt/) is a program aiming at the creation and sustained development of national integrated information ecosystem to support research management, according best international standards practices. This includes outcomes outputs modules, in particular institutional repositories managed by nationwide service RCAAP (Scientific Open Access Repository Portugal – http://www.rcaap.pt/). In order achieve such vision, has two main...
Acknowledging the benefits associated with open access (OA) to scientific literature, Foundation for Science and Technology (Fundação para a Ciência e Tecnologia - FCT), national funding agency science in Portugal, defined an OA policy that aims at ensuring free, online publications arising from FCT-funded research. Key implementation of FCT is existence solid mature repository infrastructure, Scientific Open Access Repository Portugal – RCAAP. Furthermore, RCAAP part PTCRIS, integrated...
The Portuguese Foundation for Science and Technology (FCT) has endorsed Plan-S since early 2021 it is working towards implementing its obligations. To ensure an effective fulfillment of open science policies, FCT a new monitoring compliance tool, that will enforce the with as well FCT's access (OA) policy. This paper details approach to implement this tool discusses challenges integrating information spread across multiple systems. be built on top infrastructures services developed by over...
Funding information is one of the pillars research ecosystem. Despite this, it still very challenging to associate scientific outputs all entities that financially support a project and stakeholders involved. To tackle such limitation, PTCRIS-a national integrated management ecosystem-developed new infrastructure funding attributed triad in Portuguese ecosystem: organizations, people projects. The SciPROJ database aggregates records (national international) science technology activities...