A5006746068- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Histone Deacetylase Inhibitors Research
- Epigenetics and DNA Methylation
- Protein Degradation and Inhibitors
- Childhood Cancer Survivors' Quality of Life
- Gene expression and cancer classification
- Bioinformatics and Genomic Networks
- Cancer Genomics and Diagnostics
- Neutropenia and Cancer Infections
- Hematopoietic Stem Cell Transplantation
- Cancer therapeutics and mechanisms
- Chronic Myeloid Leukemia Treatments
- Advanced biosensing and bioanalysis techniques
- Hemoglobinopathies and Related Disorders
- Neuroblastoma Research and Treatments
- RNA modifications and cancer
- COVID-19 Clinical Research Studies
- CRISPR and Genetic Engineering
- Genomics and Chromatin Dynamics
- Gut microbiota and health
- MicroRNA in disease regulation
- Plant Molecular Biology Research
- Lung Cancer Treatments and Mutations
- Metabolomics and Mass Spectrometry Studies
University of Tennessee Health Science Center
2012-2025
First Hospital of Jilin University
2017-2025
Jilin University
2017-2025
St. Jude Children's Research Hospital
2015-2024
Cancer Research And Biostatistics
2009-2024
Prevention Institute
2024
CAO Group (United States)
2019-2021
University of Memphis
2020
University of Alabama at Birmingham
2018
University of Southern California
2013
Abstract Analysis of molecular aberrations across multiple cancer types, known as pan-cancer analysis, identifies commonalities and differences in key biological processes that are dysregulated cells from diverse lineages. Pan-cancer analyses have been performed for adult 1,2,3,4 but not paediatric cancers, which commonly occur developing mesodermic rather than epithelial tissues 5 . Here we present a study somatic alterations, including single nucleotide variants, small insertions or...
Abstract Background In hospitalized patients with coronavirus disease 2019 (COVID-19) pneumonia, progression to acute respiratory failure requiring invasive mechanical ventilation (MV) is associated significant morbidity and mortality. Severe dysregulated systemic inflammation the putative mechanism. We hypothesize that early prolonged methylprednisolone (MP) treatment could accelerate resolution, decreasing need for intensive care unit (ICU) admission Methods conducted a multicenter...
Pediatric acute lymphoblastic leukemia (ALL) is the prototype for a drug-responsive malignancy. Although cure rates exceed 80%, considerable unexplained interindividual variability exists in treatment response.To assess contribution of inherited genetic variation to therapy response and identify germline single-nucleotide polymorphisms (SNPs) associated with risk minimal residual disease (MRD) after remission induction chemotherapy.Genome-wide interrogation 476,796 SNPs genotypes that were...
In acute myeloid leukemia (AML), initial treatment response by morphologic analysis of bone marrow predicts long-term outcome. Response can now be assessed minimal residual disease (MRD) monitoring with flow cytometry or polymerase chain reaction (PCR). We determined the relation among results these approaches and their prognostic value.In multicenter AML02 study, follow-up samples from 203 children adolescents newly diagnosed AML were examined (n = 1,514), morphology 1,382), PCR...
Pediatric de novo acute myeloid leukemia (AML) is an aggressive malignancy with current therapy resulting in cure rates of only 60%. To better understand the cause marked heterogeneity therapeutic response and to identify new prognostic markers targets a comprehensive list genetic mutations that underlie pathogenesis AML needed. approach this goal, we examined diagnostic leukemic samples from cohort 111 children using single-nucleotide-polymorphism microarrays candidate gene resequencing....
Purpose Germline TP53 variation is the genetic basis of Li-Fraumeni syndrome, a highly penetrant cancer predisposition condition. Recent reports germline variants in childhood hypodiploid acute lymphoblastic leukemia (ALL) suggest that this type another manifestation syndrome; however, pattern, prevalence, and clinical relevance ALL remain unknown. Patients Methods Targeted sequencing coding regions was performed 3,801 children from Children's Oncology Group frontline trials, AALL0232 P9900....
DNA hypermethylation and histone deacetylation are pathways of leukemia resistance. We investigated the tolerability efficacy decitabine vorinostat plus chemotherapy in relapse/refractory acute lymphoblastic (ALL). Decitabine (15 mg/m(2) iv) (230 PO div BID) were given days 1-4 followed by vincristine, prednisone, PEG-asparaginase, doxorubicin. Genome wide methylation profiles performed 8 matched patient bone marrow (BM) samples taken at day 0 5 (postdecitabine). The median age was 16...
Background: Hyperglycemia is common in acute ischemic stroke and associated with worse outcomes higher rates of symptomatic intracerebral hemorrhage following reperfusion therapy. Current protocols prioritize time-sensitive treatments, often overlooking hyperglycemia management during the emergent phase care. Objective: This qualitative study explores emergency department registered nurses (EDRNs) coordinators' knowledge, perceptions, barriers regarding patients undergoing Methods: A...
Abstract Viviparous1 (Vp1) encodes a B3 domain-containing transcription factor that is key regulator of seed maturation in maize (Zea mays). However, the mechanisms Vp1 regulation are not well understood. To examine physiological factors may regulate expression, transcript levels were monitored maturing embryos placed culture under different conditions. Expression decreased after hormone-free medium, but was induced by salinity or osmotic stress. Application exogenous abscisic acid (ABA)...
Abstract BACKGROUND: The effect of body mass index (BMI) on the treatment outcomes children with acute myeloid leukemia (AML) is unclear and needs further evaluation. METHODS: Children AML (n = 314) who were enrolled in 4 consecutive St. Jude protocols grouped according to BMI (underweight, <5th percentile; healthy weight, 5th 85th overweight/obese, ≥85th percentile). RESULTS: Twenty‐five patients (8%) underweight, 86 (27.4%) 203 (64.6%) had weight. 5‐year overall survival rate...
Abstract Purpose: The purpose of this study was to evaluate clinical implications CD33 single-nucleotide polymorphisms (SNP) in pediatric patients with acute myeloid leukemia (AML) treated gemtuzumab-ozogamicin (GO)–based therapy. Experimental Design: We genotyped four SNPs: rs35112940 (G&gt;A; Arg304Gly), rs12459419 (C&gt;T; Ala14Val), rs2455069 (A&gt;G; Arg69Gly), and rs1803254 (G&gt;C; 3′UTR) undergoing induction chemotherapy containing GO (COG-AAML03P1 trial; n = 242) or...
BACKGROUND Intensive chemotherapy for pediatric acute myeloid leukemia incurs the risk of infectious complications, but benefits antibiotic prophylaxis remain unclear. METHODS In current study, among 103 children treated on AML02 protocol between October 2002 and 2008 at St. Jude Children's Research Hospital, authors retrospectively assessed effect frequency febrile neutropenia, clinically or microbiologically confirmed infections (including bacteremia), resistance, as well results nasal...
Despite a growing interest in multi-omic research, individual investigators may struggle to collect large-scale omic data, particularly from human subjects. Publicly available datasets can help address this problem, including those sponsored by the NIH Common Fund, such as Genotype-Tissue Expression (GTEx) database. This database contains genotype and expression data obtained 54 non-diseased tissues But these are often underutilized, because users find browsing tools be counterintuitive or...
Glutaminase (GLS), a crucial gene regulating glutaminolysis, has received much attention as it was found to regulate tumor metabolism and copper-induced cell death. However, its biological roles mechanisms in human cancers remain obscure. Consequently, the integrated pan-cancer analyses experiments were conducted elucidate oncological functions. We GLS differentially expressed upregulated predicted poor survival, clinicopathological progression, heterogeneity. Single-cell analysis closely...
ABSTRACT Increasing attention has been paid to investigations on how social determinants of health (SDOH; e.g., income, employment, education, housing, etc.) impact outcomes. However, these variables are often not collected in routine clinical practice. As a consequence, researchers may attempt link retrospective medical records those datasets that can provide additional SDOH information, such as the Area Deprivation Index (ADI). time‐consuming geographic calculations deter analyses. To...