A5008715436- Global Cancer Incidence and Screening
- Iron Metabolism and Disorders
- Pregnancy and preeclampsia studies
- ATP Synthase and ATPases Research
- Cervical Cancer and HPV Research
- Neuroscience and Neuropharmacology Research
- Health Systems, Economic Evaluations, Quality of Life
- Maternal and fetal healthcare
- Migration, Health and Trauma
- Economic and Financial Impacts of Cancer
- Pharmaceutical Economics and Policy
- Health Literacy and Information Accessibility
- Cardiac Ischemia and Reperfusion
- Redox biology and oxidative stress
- Hemoglobinopathies and Related Disorders
- Mitochondrial Function and Pathology
- Biotechnology and Related Fields
University Hospitals Plymouth NHS Trust
2019-2020
Derriford Hospital
2019
University of Cambridge
2018
Addenbrooke's Hospital
2018
MRC Mitochondrial Biology Unit
2015
University of Cape Town
2014
Superoxide is the proximal reactive oxygen species (ROS) produced by mitochondrial respiratory chain and plays a major role in pathological oxidative stress redox signaling. While there are tools to detect or decrease superoxide, none can rapidly specifically increase superoxide production within matrix. This lack impedes progress, making it challenging assess accurately roles of cells vivo. To address this unmet need, we synthesized characterized mitochondria-targeted cycler, MitoParaquat...
Background Measuring factors influencing time to presentation is important in developing and evaluating interventions promote timely cancer diagnosis, yet there a lack of validated, culturally relevant measurement tools. This study aimed develop validate the African Women Awareness CANcer (AWACAN) tool measure awareness breast cervical Sub-Saharan Africa (SSA). Methods Development AWACAN followed 4 steps: 1) Item generation based on existing measures literature. 2) Refinement items via...
Sphingosine-1-phosphate (S1P) is a cardioprotective agent. Signal transducer and activator of transcription 3 (STAT-3) key mediator many agents. We aimed to explore whether STAT-3 in S1P-induced preconditioning.Langendorff-perfused hearts from Wistar rats wild-type or cardiomyocyte-specific knockout mice were pre-treated with S1P (10 nmol/l), without the pathway inhibitor AG490, before an ischaemia-reperfusion insult. Triphenyltetrazolium chloride Evans blue staining used for determination...
Title: Implementation of early management iron deficiency in pregnancy during the SARS-CoV-2 pandemicStewart T1, Lambourne J2, Thorpe-Jones D1, Thomas DW1.1University Hospitals Plymouth NHS Trust, Plymouth, Devon, PL6 8DH. 2East Kent Foundation William Harvey Hospital, Kennington Road, Willesborough, Ashford, Kent, TN24 0LZ