A5006382071- Global Maternal and Child Health
- Autopsy Techniques and Outcomes
- Child Nutrition and Water Access
- Vaccine Coverage and Hesitancy
- Data-Driven Disease Surveillance
- Healthcare cost, quality, practices
- Poverty, Education, and Child Welfare
- Malaria Research and Control
- Food Security and Health in Diverse Populations
- Climate Change and Health Impacts
- Mosquito-borne diseases and control
- COVID-19 Clinical Research Studies
- Medical Coding and Health Information
- Health disparities and outcomes
- Forensic Entomology and Diptera Studies
- Global Health and Epidemiology
- COVID-19 and healthcare impacts
- HIV/AIDS Research and Interventions
- Tuberculosis Research and Epidemiology
- Pregnancy and preeclampsia studies
- Viral Infections and Outbreaks Research
- COVID-19 Impact on Reproduction
- Child and Adolescent Health
- Maternal and Neonatal Healthcare
- Trauma and Emergency Care Studies
Manhiça Health Research Centre
2011-2025
Barcelona Institute for Global Health
2016-2025
University of Sierra Leone
2024
Universitat de Barcelona
2015-2024
Médecins Sans Frontières
2024
Health Net
2023
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública
2020-2022
Hospital Clínic de Barcelona
2016
Barcelona Centre for International Affairs
2011
Background There is an urgent need to identify tools able provide reliable information on the cause of death in low-income regions, since current methods (verbal autopsy, clinical records, and complete autopsies) are either inaccurate, not feasible, or poorly accepted. We aimed compare performance a standardized minimally invasive autopsy (MIA) approach with that gold standard, diagnostic (CDA), series adults who died at Maputo Central Hospital Mozambique. Methods Findings In this...
Background. There is some consensus that malaria in pregnancy may negatively affect infant's mortality and morbidity, but there less evidence concerning the factors involved. Methods. A total of 1030 Mozambican pregnant women were enrolled a randomized, placebo-controlled trial intermittent preventive treatment with sulfadoxine-pyrimethamine, their infants followed up throughout infancy. Overall morbidity rates recorded. The association maternal fetal risk infant was assessed. Results. 58...
Over 5 million stillbirths and neonatal deaths occur annually. Limited imprecise information on the cause of these hampers progress in achieving global health targets. Complete diagnostic autopsies (CDAs)-the gold standard for death determination-are difficult to perform most high-burden settings. Therefore, validation simpler more feasible methods is needed.In this observational study, validity a minimally invasive autopsy (MIA) method determining was assessed 18 41 by comparing results MIA...
Background In recent decades, the world has witnessed unprecedented progress in child survival. However, our knowledge of what is killing nearly 6 million children annually low- and middle-income countries remains poor, partly because inadequacy reduced precision methods currently utilized these settings to investigate causes death (CoDs). The study objective was validate use a minimally invasive autopsy (MIA) approach as an adequate more acceptable substitute for complete diagnostic (CDA)...
The minimally invasive autopsy (MIA) is being investigated as an alternative to complete diagnostic autopsies for cause of death (CoD) investigation. Before potential implementation the MIA in settings where post-mortem procedures are unusual, a thorough assessment its feasibility and acceptability essential.We conducted socio-behavioural study at community level understand local attitudes perceptions related hypothetical conducting MIAs six distinct Gabon, Kenya, Mali, Mozambique, Pakistan....
Tuberculosis (TB) control is more likely to be achieved if the level of knowledge regarding TB increased among health workers managing high-risk groups. No formal assessments knowledge, attitudes and practises about have been published for Mozambique, a country facing challenges in fight against TB, with fragile system considerable work overload personnel. The main objective study was determine identify assess practices care district Manhiça.A descriptive cross-sectional performed through...
Background Despite global health efforts to reduce maternal mortality, rates continue be unacceptably high in large parts of the world. Feasible, acceptable, and accurate postmortem sampling methods could provide necessary evidence improve understanding real causes guiding design interventions this burden. Methods findings The validity a minimally invasive autopsy (MIA) method determining cause death was assessed an observational study 57 deaths by comparing results MIA with those gold...
Sex and gender are important determinants of health. Gender-based health inequities in the paediatric population have been reported various countries, but data remain limited. In Mozambique, research on this topic is very scarce. Here we aimed to explore whether boys girls Manhiça district, southern differ access provision healthcare. This retrospective analysis includes all (<15 years old) visits six outpatient clinics admissions one hospital district from 2004 2020, collected through...
Background Malaria in pregnancy is a public health problem for endemic countries. Economic evaluations of malaria preventive strategies are needed to guide policies. Methods and Findings This analysis was carried out the context trial intermittent treatment with sulphadoxine-pyrimethamine (IPTp-SP), where both intervention groups received an insecticide treated net through antenatal clinic (ANC) Mozambique. The cost-effectiveness IPTp-SP on maternal clinical neonatal survival estimated....
Postmortem studies are crucial for providing insight into emergent diseases. However, a complete autopsy is frequently not feasible in highly transmissible diseases due to biohazard challenges. Minimally invasive (MIA) needle-based approach aimed at collecting samples of key organs without opening the body, which may be valid alternative these cases. We to: (a) provide biosafety guidelines conducting MIAs COVID-19 cases, (b) compare performance MIA versus autopsy, and (c) evaluate safety...
<ns4:p><ns4:bold>Background</ns4:bold>: Accurate information on causes of death (CoD) is essential to estimate burden disease, track global progress, prioritize cost-effective interventions, and inform policies reduce mortality. In low-income settings, where a significant proportion deaths take place at home or in poorly-resourced peripheral health facilities, data CoD often relies verbal autopsies (VAs). Validations VAs have been performed against clinical diagnosis, but never before an...
Background Low Birth Weight (LBW) is prevalent in low-income countries. Even though the economic evaluation of interventions to reduce this burden essential guide health policies, data on costs associated with LBW are scarce. This study aims estimate system and household Disability Adjusted Life Years (DALYs) arising from infant deaths Southern Mozambique. Methods Findings Costs incurred by households were collected through exit surveys. Health gathered obtained onsite published information....
<ns4:p><ns4:bold>Background</ns4:bold>: Accurate information on causes of death (CoD) is essential to estimate burden disease, track global progress, prioritize cost-effective interventions, and inform policies reduce mortality. In low-income settings, where a significant proportion deaths take place at home or in poorly-resourced peripheral health facilities, data CoD often relies verbal autopsies (VAs). Validations VAs have been performed against clinical diagnosis, but never before an...
Background The minimally invasive autopsy (MIA) is being investigated as an alternative to the complete diagnostic (CDA), gold standard for CoD determination, in settings where CDA unfeasible and/or unacceptable. We aimed explore healthcare providers' views and perceptions on theoretical factual acceptability of MIA. Methods A qualitative study, combining ethnographic grounded-theory approaches, was conducted within a project aiming validate MIA tool against investigation. present data...
Abstract Postmortem studies, including the complete diagnostic autopsy (CDA) and minimally invasive (MIA), an innovative approach to post-mortem sampling cause of death investigation, are commonly performed within 24 hours after because quality tissues deteriorates over time. This short timeframe may hamper feasibility procedure. In this study, we compared performance two postmortem procedures when carried out earlier later than death, as well impact increasing intervals (PMIs) on results...
The Child Health and Mortality Prevention Surveillance (CHAMPS) program is a 7-country network (as of December 2018) established by the Bill & Melinda Gates Foundation to identify causes death in children communities with high rates under-5 mortality. carries out both mortality pregnancy surveillance, surveillance employs minimally invasive tissue sampling (MITS) gather small samples body fluids from bodies who have died. While this method will lead greater knowledge specific childhood...
The Child Health and Mortality Prevention Surveillance (CHAMPS) network aims to generate reliable data on the causes of death among children aged <5 years using all available information, including minimally invasive tissue sampling (MITS). sensitive nature MITS inevitably evokes religious, cultural, ethical questions influencing feasibility sustainability CHAMPS.Due limited behavioral studies related child MITS, we developed an innovative qualitative methodology determine barriers,...
Background Clinico-pathological discrepancies are more frequent in settings which limited diagnostic techniques available, but there is little information on their actual impact. Aim We assessed the accuracy of clinical diagnoses a tertiary referral hospital sub-Saharan Africa by comparison with post-mortem findings. also identified potential risk factors for misdiagnoses. Methods One hundred and twelve complete autopsy procedures were performed at Maputo Central Hospital (Mozambique), from...
Background The implementation of quality HIV control programs is crucial for the achievement UNAIDS 90-90-90 targets and to motivate people living with (PLWHIV) link remain in HIV-care. aim this mixed method cross-sectional study was estimate linkage long-term retention care PLWHIV identify factors potentially interfering along HIV-care continuum southern Mozambique. Methods A home-based semi-structured interview conducted 2015 explore barriers facilitators cascade among individuals that had...
Similar to other epidemics, knowledge about Zika virus (ZIKV) relies upon information often coming from outside the health system. This study aimed explore views, perceptions and attitudes towards ZIKV among migrant women Central South America, diagnosed with infection during pregnancy, comprehend healthcare professionals’ of ZIKV. An exploratory qualitative study, based on phenomenology grounded theory, was conducted in Barcelona, Spain. Data were collected through in-depth paired...
BackgroundAlthough an increasing number of pregnant women in resource-limited areas deliver health-care facilities, maternal mortality remains high these settings. Inadequate diagnosis and management common life-threatening conditions is important determinant mortality. We analysed the clinicopathological discrepancies a series deaths from Mozambique assessed changes over 10 years diagnostic process. aimed to provide data on clinical accuracy be used for improving quality care reducing...
Abstract Background Available information on the causes of death among people living with human immunodeficiency virus (PLHIV) in low- and middle-income countries (LMICs) remains scarce. We aimed to provide data PLHIV from two LMICs, Brazil Mozambique, assess impact clinical misdiagnosis mortality rates evaluate accuracy minimally invasive tissue sampling (MITS) determining cause PLHIV. Methods performed coupled MITS complete autopsy 164 deceased (18 children, 36 maternal deaths, 110...
Abstract Background Malnutrition among children under five years of age is a major public health issue in many low and middle-income constrained countries. According to WHO, 5.3 million under-five die every year about 45% these deaths are linked malnutrition. While it clear that poverty lack food important factors children’s malnutrition, less known the ways which local conceptions malnutrition affect parents’ treatment choices. In Ethiopia, child severe problem common cause death, this...
Background The epidemic of Zika virus (ZIKV) was associated with a sudden and unprecedented increase in infants born microcephaly. Colombia the second most affected country by Americas. Primary caregivers children ZIKV-associated microcephaly, their mothers mainly, were at higher risk suffering anxiety depression. Often, these women stigmatized abandoned partners, relatives, communities. Methodology/Principal findings This study aimed to understand perceptions about ZIKV infection among...
The Countrywide Mortality Surveillance for Action project aims to implement a child mortality surveillance program through strengthening vital registration event reporting (pregnancy, birth, and death) investigating causes of death (CODs) based on verbal autopsies. In Quelimane (central Mozambique), Minimally Invasive Tissue Sampling (MITS) procedures were added fine-tune the COD approaches. Before implementation MITS, an evaluation acceptability ethical considerations was considered...