A5101797015- Pulmonary Hypertension Research and Treatments
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Acute Ischemic Stroke Management
- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Aging and Gerontology Research
- Caveolin-1 and cellular processes
- Health disparities and outcomes
- Cutaneous lymphoproliferative disorders research
- Venous Thromboembolism Diagnosis and Management
- Cell Image Analysis Techniques
- Thermoregulation and physiological responses
- Retirement, Disability, and Employment
- Cardiac electrophysiology and arrhythmias
- Tea Polyphenols and Effects
- Global Public Health Policies and Epidemiology
- Microencapsulation and Drying Processes
- Ion Transport and Channel Regulation
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Function and Risk Factors
- Adipose Tissue and Metabolism
- Atrial Fibrillation Management and Outcomes
- Nitric Oxide and Endothelin Effects
- Ion channel regulation and function
Universidade do Porto
2010-2024
Hospital Braga
2023
Ministry of Health
2010
Eduardo Mondlane University
2010
Baker Heart and Diabetes Institute
2010
Already a major cause of death and disability in high-income countries, the burden stroke sub-Saharan Africa is also expected to be high. However, specific data are scarce from resource-poor countries. We studied incidence, characteristics, short-term consequences hospitalizations for Maputo, Mozambique.Over 12 months, comprehensive all local patients admitted any hospital Maputo with new event were prospectively captured according World Health Organization's STEPwise approach surveillance...
The burden of stroke is increasing in developing countries that struggle to manage it efficiently. We identified determinants early case-fatality among patients Maputo, Mozambique, assess the impact in-hospital complications. Patients admitted any hospital Maputo with a new event were prospectively registered ( n = 651) according World Health Organization's STEPwise approach, 2005–2006. assessed and 28-day fatality, independently age, gender education, computed population attributable...
Pulmonary arterial hypertension (PAH) is a chronic disorder characterized by excessive pulmonary vascular remodeling, leading to elevated resistance and right ventricle (RV) overload failure. MicroRNA-146a (miR-146a) promotes smooth muscle cell proliferation neointimal hyperplasia, both hallmarks of PAH. This study aimed investigate the effects miR-146a through pharmacological or genetic inhibition on experimental PAH RV pressure animal models. Additionally, we examined overexpression human...
It was suggested that intravenous thrombolysis (IT) leads to larger extent recanalization in cardioembolic stroke. In this work we assess if has beneficial clinical traduction.We evaluated 177 patients undergoing IT, which were categorized into (CE) and non-cardioembolic (NCE). National Institutes of Health Stroke Scale (NIHSS) modified Rankin scale compared.The mean age 67.4 ± 12.01 53.8% male. The NIHSS was: 14 (admission), 9 (24 h) 6 (discharge), similar subgroups. difference between at...
Depression rates are notably higher in older adults residing long-term care compared to their community-dwelling counterparts. The complexity of needs for this group is growing, yet the specific risk factors depression remain poorly defined. review consolidates current knowledge on depression, aiming bridge these gaps idenOficaOon and intervenOon development. Searches were performed using 3 databases: pubmed, scopus web science, research original arOcles published 2000-2023. 8 studies...
Pre-exposure prophylaxis (PrEP) has gained relevance as a method of prevention for HIV in certain people and settings. Following the publication guideline on PrEP prescribing Portugal, we aimed to assess knowledge Portuguese Medical Students about PrEP.An online survey was sent students Schools. We conducted descriptive analysis results an analytic cross-sectional study identify factors associated with "knowing PrEP", "having had one class PrEP" "identifying eligible groups correctly".Of 796...
We describe the case of a 73-year-old female patient with priors mantle cell lymphoma (MCL), diagnosed 9 months ago, treated chemotherapy, and currently maintenance rituximab therapy, total knee replacement on left leg 1 year ago.The presented to Dermatology Department patches leg, 3 evolution.On examination, infiltrated, confluent erythematous-violaceous plaques, anterior surface along arthroplasty scar.No complaints associated.Blood work showed anaemia, neutropenia an elevation lactate...
Pulmonary arterial hypertension (PAH), is a chronic disorder characterized by excessive pulmonary vascular remodelling, resulting in elevated resistance and right ventricle (RV) overload failure. PAH remains incurable, new therapeutic approaches are required. MicroRNA-146a (miR-146a) promotes smooth muscle cell proliferation neointimal hyperplasia, both important hallmarks of PAH. This study aims to investigate miR-146a role the pathophysiology RV Sprague Dawley rats received subcutaneous...
Pulmonary arterial hypertension (PAH), is a chronic disorder characterized by excessive pulmonary vascular remodelling, resulting in elevated resistance and right ventricle (RV) overload failure. PAH remains incurable, new therapeutic approaches are required. The microRNA-146a (miR-146a) promotes smooth muscle cell proliferation neointimal hyperplasia, both important hallmarks of PAH.This study aimed to investigate the role miR-146a pathophysiology progression RV hypertrophy failure.Sprague...
Abstract Introduction Although initially believed to be less severe than heart failure with reduced ejection fraction (HFrEF), preserved (HFpEF) prevalence has increased and accounts for as much 50% of cases [1,2]. Treatment options remain limited aim primarily symptom relief improvement quality life [2]. Urocortin-2 (Ucn-2) belongs the corticotrophin-releasing hormone (CRH) family been found have significant beneficial hemodynamic, hormonal renoprotective effects both in animal models...