A5109954377- HIV-related health complications and treatments
- Hepatitis C virus research
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- HIV/AIDS Research and Interventions
- Viral-associated cancers and disorders
- Cytomegalovirus and herpesvirus research
- COVID-19 Clinical Research Studies
- Systemic Lupus Erythematosus Research
- Immune Cell Function and Interaction
- Diabetes and associated disorders
- SARS-CoV-2 and COVID-19 Research
- Microscopic Colitis
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Gastrointestinal disorders and treatments
- Parvovirus B19 Infection Studies
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- interferon and immune responses
- Platelet Disorders and Treatments
- Healthcare Systems and Practices
- T-cell and B-cell Immunology
- Folate and B Vitamins Research
Paris Biotech Santé
2024
Innovation Research Center
2019
InnaVirVax (France)
2014
Sorbonne Université
1990-2013
Vertex Pharmaceuticals (United States)
2006-2013
Icahn School of Medicine at Mount Sinai
2013
Johns Hopkins Medicine
2013
Johns Hopkins University
2013
Hospital Clínico San Carlos
2013
University of Bonn
2013
In patients with chronic infection hepatitis C virus (HCV) genotype 1, treatment peginterferon alfa and ribavirin for 48 weeks results in rates of sustained virologic response 40 to 50%. Telaprevir is a specific inhibitor the HCV serine protease could be value treatment.A total 334 who had 1 not been treated previously were randomly assigned receive one four treatments involving various combinations telaprevir (1250 mg on day then 750 every 8 hours), alfa-2a (180 microg weekly), (dose...
Adipocytokines, secreted by adipose tissue, may regulate fat metabolism, lipid and glucose homeostasis insulin sensitivity. We analysed the relations between circulating concentrations of adiponectin, leptin, interleukin-6, tumor necrosis factor alpha its soluble receptors sTNFR1 R2, lipodystrophic phenotypes metabolic alterations in patients under highly active antiretroviral therapy (HAART).We studied 131 consecutive HIV-infected males protease inhibitor (PI)-based HAART, with body mass...
Chinese translation Background: Telaprevir (TVR) plus peginterferon-α2a (PEG-IFN-α2a) and ribavirin substantially increases treatment efficacy for genotype 1 chronic hepatitis C virus (HCV) infection versus PEG-IFN-α2a–ribavirin alone. Its safety in patients with HCV HIV-1 are unknown. Objective: To assess the of TVR to evaluate pharmacokinetics antiretrovirals during coadministration. Design: Phase 2a, randomized, double-blind, placebo-controlled study. (ClinicalTrials.gov: NCT00983853)...
The serum levels of cortisol, progesterone, 17α-hydroxyprogesterone, dehydroepiandrosterone (DHEA), DHEA sulfate, androstenedione (δ4), testosterone (T), estrone, and estradiol HIV + men HIV- were determined by radioimmunoassay. estrone all HIV+ subjects 35–55% (p < 0.01), 25–90% 30–50% 0.01) higher, respectively, than those controls. Androgen very high in Centers for Disease Control (CDC) groups II III infection (DHEA, 85%, p 0.01; δ4, 60%, T, 30%, 0.05), but much lower group IVC1 IVC2....
Summary. In HIV/hepatitis C virus (HCV)‐coinfected patients, it is recommended to repeat liver biopsy every 3 years when anti‐HCV treatment not indicated. We studied fibrosis progression in HIV/HCV‐coinfected who were receiving treatment, on the basis of two successive biopsies. Thirty‐two patients retrospectively included. Twenty‐six (79%) antiretroviral at first biopsy. The mean CD4 cell count was 470 ± 283/mm . Three staged F2 and remainder F0/F1. median interval between biopsies 49...
Merimepodib (MMPD) is an orally administered, inosine monophosphate dehydrogenase inhibitor that has shown antiviral activity in nonresponders with chronic hepatitis C (CHC) when combined pegylated interferon alfa 2a (Peg-IFN-alfa-2a) and ribavirin (RBV). We conducted a randomized, double-blind, multicenter, phase 2b study to evaluate the activity, safety, tolerability of MMPD combination Peg-IFN-alfa-2a RBV patients genotype 1 CHC who were prior therapy Peg-IFN RBV. Patients received 50 mg...
VAC-3S is a therapeutic vaccine comprising highly conserved HIV-gp41 motif coupled with the CRM197 carrier protein. High levels of anti-3S antibodies (Abs) have been associated improved protection CD4+ T-cell survival. A previous phase 1 study demonstrated safety VAC-3S. This multicentre, randomised, double-blind, placebo-controlled 2 clinical trial enroled between January 2014 and March 2015 HIV-1-infected patients under ART plasma HIV RNA below 50 copies/mL CD4 counts 200 500 cells/μL....
Abstract: This phase IIa, randomised, single‐blind, placebo‐controlled study was conducted to determine the dose of recombinant human granulocyte colony‐stimulating factor (lenograstim) suitable for use in AIDS patients. The at 27 European AIDS/HIV centres, and recruited 69 patients with an initial episode or relapse cytomegalovirus infection (neurological site excluded) absolute neutrophil count (ANC) 1.0×10 9 /L upon diagnosis between days 1 12 ganciclovir (GCV) treatment. were randomised...
Abstract COVID‐19 manifests as a mild disease in most people but can progress to severe nearly 20% of individuals. Disease progression is likely driven by cytokine storm, either directly stimulated SARS‐CoV‐2 or increased systemic inflammation which the gut might play an integral role. replication may cause intestinal permeability, alterations fecal microbiome, and inflammatory cytokines. Each effect lead transport cytokines antigens from lung. Few interventions are being studied treat with...
AIM--Since most forms of Kaposi sarcoma are much more common in men than women, the aim this study was to examine serum concentrations sex steroids HIV positive with and without sarcoma. METHODS--Blood samples from 34 (KS-) 28 (KS+) 35 negative (controls) were analysed for adrenal gonadal steroids. Further analysis done subgroups classified by CD4 lymphocyte counts. RESULTS--KS+ patients had significantly higher dehydroepiandrosterone (DHEA) testosterone KS- patients, their DHEA, DHEA...