A5018524982- Biofuel production and bioconversion
- Enzyme Production and Characterization
- Microbial Metabolites in Food Biotechnology
- Probiotics and Fermented Foods
- Clostridium difficile and Clostridium perfringens research
- SARS-CoV-2 and COVID-19 Research
- Monoclonal and Polyclonal Antibodies Research
- Animal health and immunology
- Gut microbiota and health
- COVID-19 Clinical Research Studies
- Protein purification and stability
- Eosinophilic Esophagitis
- COVID-19 and Mental Health
- Protein Interaction Studies and Fluorescence Analysis
- Advanced Drug Delivery Systems
- Exercise and Physiological Responses
- Advanced Biosensing Techniques and Applications
- Celiac Disease Research and Management
- Gastrointestinal disorders and treatments
- COVID-19 Impact on Reproduction
- Immunotherapy and Immune Responses
- Protein Structure and Dynamics
- Polymer Surface Interaction Studies
- Diabetes and associated disorders
- Helicobacter pylori-related gastroenterology studies
Reliant Technologies (United States)
2023-2024
Ligand Pharmaceuticals (United States)
2023
Amita Health
2015-2021
Essentia Health
2015
Iowa State University
2009-2012
Cows produce antibodies with a disulfide-bonded antigen-binding domain embedded within ultralong heavy chain third complementarity determining regions. This "knob" is analogous to natural cysteine-rich peptides such as knottins in that it small and stable but can accommodate diverse loops disulfide bonding patterns. We immunized cattle SARS-CoV-2 spike found CDR H3 could neutralize several viral variants at picomolar IC
Serum-derived bovine immunoglobulin (SBI) prevents translocation and inflammation via direct binding of microbial components. Recently, SBI also displayed potential benefits through gut microbiome modulation. To confirm expand upon these preliminary findings, digestion colonic fermentation were investigated using the clinically predictive ex vivo SIFR® technology (for 24 human adults) that was, for first time, combined with host cells (epithelial/immune (Caco-2/THP-1) cells). (human...
Intestinal barrier dysfunction is associated with chronic gastrointestinal tract inflammation and diseases such as IBD IBS. Serum-derived bovine immunoglobulin/protein isolate (SBI) a specially formulated protein preparation (>90%) for oral administration. The composition of SBI greater than 60% immunoglobulin including contributions from IgG, IgA, IgM. Immunoglobulin within the lumen gut has been recognized to have anti-inflammatory properties involved in maintaining homeostasis. binding...
Serum-derived bovine immunoglobulins (SBI) exert health benefits mediated by their ability to bind microbial components, thereby preventing translocation and subsequent inflammation. While in vivo studies have shown that a fraction of SBI also reaches the colon, little is known about impact on dense colonic microbiota has great potential human health. This study, therefore, investigated three plasma protein fractions (SBI, (BP) albumin-enriched (ABP)) gut six adults using novel ex SIFR®...
ABSTRACT A gene encoding a glycoside hydrolase family 44 (GH44) protein from Clostridium acetobutylicum ATCC 824 was synthesized and transformed into Escherichia coli. The previously uncharacterized expressed with C-terminal His tag purified by nickel-nitrilotriacetic acid affinity chromatography. Crystallization X-ray diffraction to 2.2-Å resolution revealed triose phosphate isomerase (TIM) barrel-like structure additional Greek key β-sandwich folds, similar other GH44 crystal structures....
Abstract COVID‐19 manifests as a mild disease in most people but can progress to severe nearly 20% of individuals. Disease progression is likely driven by cytokine storm, either directly stimulated SARS‐CoV‐2 or increased systemic inflammation which the gut might play an integral role. replication may cause intestinal permeability, alterations fecal microbiome, and inflammatory cytokines. Each effect lead transport cytokines antigens from lung. Few interventions are being studied treat with...
Binding and thermodynamic properties of a carbohydrate binding module (CBM) glycoside hydrolase family 44 xyloglucanase/endoglucanase catalytic domain (CD) from Ruminococcus flavefaciens, both when separate linked to each other, have been quantified various β-1,4-linked glucans xylans. The three constructs bind cellotetraose, cellopentaose, cellohexaose with association constants that increase chain length. CBM does not xylotetraose, xylopentaose, or xylohexaose. CD appears...
Effective treatment to prevent hospitalization and death in people with COVID-19 exists, but still need interventions that alleviate symptoms without drug interactions. Oral serum-derived bovine immunoglobulins (SBI) may reduce time-to-improvement mild-to-moderate COVID-19. In this randomized, open-label, single-site study, participants received SBI 5.0 g bis die (BID) + Standard of Care (SOC) or SOC alone (2:1) for 2 weeks. After weeks, 78.8% hospitalized on improved by World Health...
Background Protein supplementation in addition to resistance training has been shown increase muscle hypertrophy and lean mass. Supplemental protein sources differ amino acid composition, size, structure, functionality. Animal derived proteins such as Beef Isolate (BeefISO), Serum Albumin Concentrate (SuperSerum), (SerumPro), whey isolate (WPI), hydrolyzed Chicken (MyoCHX) each have high-quality profiles. The mammalian target of rapamycin (mTOR) signal pathway is a nutrient sensor whose...
The gut microbiome plays a crucial role in the health of its host by regulating metabolism and protecting against pathogens. One key functions is to produce short-chain fatty acids (SCFAs), including acetate, propionate, butyrate. Though each SCFA has distinct benefits, all SCFAs have anti-inflammatory effects decrease pH colonic lumen which increases mineral absorption inhibits growth Previous studies show that various fractions bovine plasma positively impact health, though their effect on...
The gut microbiome consists of a complex population bacteria, fungi, and viruses that aid the host in various physiological functions. When microbiota is imbalanced, known as dysbiosis, symbiotic microbes can become opportunistic excrete virulence factors decrease intestinal barrier function, causing chronic inflammation leads to disease. Therefore, maintaining balance critical overall health. Endogenous immunoglobulins play positive role homeostasis immunoglobulin supplements assist body...