A5039829623- Immune cells in cancer
- CAR-T cell therapy research
- Monoclonal and Polyclonal Antibodies Research
- Cancer Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Advanced Biosensing Techniques and Applications
- Immune Cell Function and Interaction
- Infant Nutrition and Health
- Immunotherapy and Immune Responses
- Epigenetics and DNA Methylation
- Phagocytosis and Immune Regulation
- Single-cell and spatial transcriptomics
- Corporate Management and Leadership
- Psychology, Coaching, and Therapy
- Biomedical and Chemical Research
- Corporate Governance and Management
- Breastfeeding Practices and Influences
- Pancreatitis Pathology and Treatment
- Nanoplatforms for cancer theranostics
- Neuroendocrine Tumor Research Advances
- Synthesis and biological activity
- Digital Innovation in Industries
- HER2/EGFR in Cancer Research
Reaction Biology (Germany)
2022-2024
Ludwig-Maximilians-Universität München
2019-2021
Center for Integrated Protein Science Munich
2018-2021
LMU Klinikum
2019-2021
German Center for Lung Research
2020
Roche (Switzerland)
2014-2016
University Medical Center Freiburg
2016
Swiss Tropical and Public Health Institute
2015
The University of Western Australia
2012-2013
University of Freiburg
2012-2013
Abstract The mammary gland undergoes significant remodeling during pregnancy and lactation, which is fuelled by controlled stem cell (MaSC) proliferation. scarcity of human lactating breast tissue specimens the low numbers quiescent state MaSCs in resting have hindered understanding both normal MaSC dynamics molecular determinants that drive their aberrant self-renewal cancer. Here, we demonstrate breastmilk contains cells (hBSCs) with multilineage properties. Breastmilk from different...
Breastmilk protects infants against infections; however, specific responses of breastmilk immune factors to different infections either the mother or infant are not well understood. Here, we examined baseline range leukocytes and immunomodulatory biomolecules in healthy mother/infant dyads how they influenced by dyad. Consistent with a greater immunological need early postpartum period, colostrum contained considerable numbers (13–70% out total cells) high levels immunoglobulins lactoferrin....
Modifications like asparagine deamidation, aspartate isomerization, methionine oxidation, and lysine glycation are typical degradations for recombinant antibodies. For the identification functional evaluation of antibody critical quality attributes (CQAs) derived from chemical modifications in complementary-determining regions (CDRs) conserved regions, an approach employing specific stress conditions, elevated temperatures, pH, oxidizing agents, forced with glucose incubation, was applied....
5′-Triphosphate RNA–induced apoptosis consists of a RIG-I–dependent priming and an OAS1/RNase L–dependent effector phase.
The tumor microenvironment (TME) combines features of regulatory cytokines and immune cell populations to evade the recognition by system. Myeloid-derived suppressor cells (MDSC) comprise immature myeloid in tumor-bearing hosts with a highly immunosuppressive capacity. We could previously identify RIG-I-like helicases (RLH) as targets for immunotherapy pancreatic cancer inducing immunogenic death type I interferons (IFN) key mediators linking innate adaptive immunity.Mice orthotopically...
Ischemia reperfusion injury (IRI) of the kidney results in IRF4-mediated counter regulation acute inflammatory response. Beyond that, IRF4 exerts important functions controlling cytokine milieu, T-cell differentiation and macrophage polarization. The latter have been implicated tissue remodeling. It therefore remains elusive, what is role terms long term outcome following IRI. We hypothesized, that an inability to resolve chronic inflammation Irf4-/- mice would promote disease (CKD)...
Pancreatic ductal adenocarcinoma is characterized by a strong immunosuppressive network with dense infiltration of myeloid cells including myeloid-derived suppressor (MDSC). Two distinct populations MDSC have been defined: polymorphonuclear (PMN-MDSC) and monocytic (M-MDSC). Several factors influence the development function transcription factor interferon regulatory 4 (IRF4). Here, we show that IRF4 deficiency accelerates tumor growth reduces survival, accompanied PMN-MDSC reduced numbers...
Abstract Background Cartilage shortage is a major problem in facial reconstructive surgery. Prior studies have shown that decellularized porcine nasal septal cartilage (DPNC) seeded with primary human chondrocytes enabled regeneration and showed potential as replacement material for cartilage. Since adipose tissue‐derived stem cells (ASCs) are easily accessible almost abundantly available, they appear to be promising alternative limited making the combination of DPNC ASCs feasible approach...
Checkpoint molecules such as programmed death 1 (PD-1) dampen excessive T cell activation to preserve immune homeostasis. PD-1-specific monoclonal antibodies have revolutionized cancer therapy, they reverse tumour-induced exhaustion and restore CTL activity. Based on this success, deciphering underlying mechanisms of PD-1-mediated functions has become an important field immunological research. Initially described for cells, there is emerging evidence unconventional PD-1 expression by myeloid...
This pilot study aimed on generating insight alterations in circulating immune cells during the use of FOLFIRINOX and gemcitabine/nab-paclitaxel pancreatic ductal adenocarcinoma (PDAC). Peripheral blood mononuclear were isolated before 30 days after initiation chemotherapy from 20 patients with advanced PDAC. Regulatory T (FoxP3+) checkpoints (PD-1 TIM-3) analyzed by flow cytometry immunological changes correlated clinical outcome. Heterogeneous observed T-cell subpopulations a pronounced...
It is well accepted that aging and HIV infection are associated with quantitative functional changes of CMV-specific T cell responses. We studied here the expression Mip-1β maturation marker CD27 within CMVpp65-specific CD4+ CD8+ cells in relation to age, active Tuberculosis (TB) co-infection a cohort Tanzanian volunteers (≤16 years n = 108 ≥18 years, 79). Independent co-infection, IFNγ+ frequencies increased age. In adults, further these cells. A high capacity for production together...