A5069300051- Vitamin D Research Studies
- Antibiotics Pharmacokinetics and Efficacy
- Antimicrobial Resistance in Staphylococcus
- Antifungal resistance and susceptibility
- Estrogen and related hormone effects
- Dialysis and Renal Disease Management
- Birth, Development, and Health
- Bone health and osteoporosis research
- Biosimilars and Bioanalytical Methods
- Pharmacological Effects and Toxicity Studies
- Mass Spectrometry Techniques and Applications
- Vitamin C and Antioxidants Research
- Neonatal Health and Biochemistry
- Hormonal and reproductive studies
- Legionella and Acanthamoeba research
- Clinical Laboratory Practices and Quality Control
- Metabolism and Genetic Disorders
- Cytomegalovirus and herpesvirus research
- Bacterial Identification and Susceptibility Testing
- Advanced Measurement and Metrology Techniques
- Urinary Tract Infections Management
- Cancer Risks and Factors
- Forensic Toxicology and Drug Analysis
- Optical measurement and interference techniques
- Chronic Kidney Disease and Diabetes
Jessa Hospital
2019-2024
KU Leuven
2012-2022
Service Public Federal Finances
2020
Universitair Ziekenhuis Leuven
2014-2018
Vrije Universiteit Brussel
2017
Erasmus MC - Sophia Children’s Hospital
2017
Maastricht University
2017
Onze Lieve Vrouwziekenhuis Hospital
2015
Learning Multi Systems (United States)
2006
D2S International (Belgium)
2000
We recently published and validated the new serum creatinine (Scr)-based full-age-spectrum equation (FAS crea ) for estimating glomerular filtration rate (GFR) healthy kidney-diseased subjects of all ages. The was based on concept normalized Scr shows equivalent to superior prediction performance currently recommended equations children, adolescents, adults older adults.Based an evaluation cystatin C (ScysC) distribution, we defined normalization constants ScysC ( Q cysC = 0.82 mg/L ages <70...
Total 25-hydroxyvitamin D (25OHD) is a marker of vitamin status and lower in African Americans than whites. Whether this difference holds for free 25OHOD (f25OHD) unclear, considering reported genetic-racial differences binding protein (DBP) used to calculate f25OHD. Our objective was assess racial-geographic f25OHD understand inconsistencies racial associations with DBP calculated This study cross-sectional design. The general community the United States, Kingdom, Gambia were included...
Abstract The vitamin D receptor is highly expressed in the gastrointestinal tract where it transacts gene expression. With current limited understanding of interactions between gut microbiome and D, we conduct a cross-sectional analysis 567 older men quantifying serum metabolites using LC-MSMS defining stool sub-Operational Taxonomic Units from16S ribosomal RNA sequencing data. Faith’s Phylogenetic Diversity non-redundant covariate analyses reveal that 1,25(OH) 2 level explains 5% variance...
The unbound drug hypothesis states that only concentrations are active and available for clearance, highly variable results regarding vancomycin fractions have been reported in the literature. We determined four different patient groups by a liquid chromatography tandem mass spectrometry (LC-MS/MS) method identified factors modulate binding. further developed validated prediction model to estimate concentrations. Vancomycin (unbound total) were measured 90 patients hospital wards (hematology...
Urinary tract infections (UTIs) are an important cause of empiric antibiotic (over)treatment at the emergency department (ED). To enhance choices, mapping national and local microbiology antimicrobial resistance (AMR) patterns is crucial. This study aims to examine a Brussels ED identify risk factors for AMR evaluate current treatment guidelines help combat AMR.
Low birth weight and prematurity are risk factors for hypertension in adulthood. Few studies preterm or full-term born children reported on plasma renin activity (PRA). We tested the hypothesis that might modulate incidence of associated with prematurity. enrolled 93 prematurely <1000 g 87 healthy controls at term, who were all examined ≈11 years. Renal length glomerular filtration rate derived from serum cystatin C 0.28 cm (95% confidence interval, 0.09–0.47) 11.5 mL/min per 1.73 m 2...
Diagnosing polycystic ovary syndrome (PCOS) is based on ovulatory dysfunction, ovarian ultrasound data, and androgen excess. Total testosterone frequently used to identify excess, but mainly bound sex hormone-binding globulin (SHBG) albumin. Only 1-2% of nonprotein-bound (so-called free testosterone) biologically active responsible for action. Moreover, automated immunoassays which are female measurements inaccurate. To assess the clinical usefulness liquid chromatography-tandem mass...
Urinary creatinine can be quantified by Jaffe or enzymatic assays and is commonly used as denominator of urinary excretion electrolytes protein. Paired analysis in pediatric adult samples documented inter-assay differences (up to 80%). We verified the interchangeability two IDMS-traceable (Jaffe enzymatic) for neonatal urine report on values using these methods. Creatinine was measured 84 from 46 neonates an IDMS traceable assay (Roche Diagnostics, Cobas c702 module). values, clinical...
Hypoglycaemia has been reported as an unusual complication of tramadol use and in a few cases poisoning, but the exact mechanism is not known.An ambulance crew was dispatched to unconscious 46-year old man. A glucometer point-of-care measurement revealed profound hypoglycaemia (1.9 mmol/L). Treatment with intravenous glucose started patient transported hospital. The had several episodes pulseless electrical activity requiring cardiopulmonary resuscitation upon arrival Despite continuous...