A5026635825- Bacterial Identification and Susceptibility Testing
- Antibiotic Resistance in Bacteria
- Antimicrobial Resistance in Staphylococcus
- Viral Infections and Vectors
- Antibiotic Use and Resistance
- Urinary Tract Infections Management
- Antibiotics Pharmacokinetics and Efficacy
- Vector-borne infectious diseases
- Forensic Entomology and Diptera Studies
- Mycobacterium research and diagnosis
- Antifungal resistance and susceptibility
- Enterobacteriaceae and Cronobacter Research
- Yersinia bacterium, plague, ectoparasites research
- Clostridium difficile and Clostridium perfringens research
- Infection Control in Healthcare
- Pneumonia and Respiratory Infections
- Orthopedic Infections and Treatments
- Fungal Infections and Studies
- Autopsy Techniques and Outcomes
- Blood groups and transfusion
- Infective Endocarditis Diagnosis and Management
- Forensic and Genetic Research
- Neonatal and Maternal Infections
- Antimicrobial agents and applications
- Syphilis Diagnosis and Treatment
KU Leuven
2013-2024
Vlaamse Vereniging voor Obstetrie en Gynaecolo
2018-2024
AZ Sint-Lucas
2022
Universitair Ziekenhuis Leuven
2010-2021
Maastricht University Medical Centre
2017
VIB-KU Leuven Center for Brain & Disease Research
2017
Institut Pasteur
2016
Centre National de la Recherche Scientifique
2016
Antwerp University Hospital
2016
VIB-KU Leuven Center for Microbiology
2015
To determine why incidence of mucormycosis infections was increasing in a large university hospital Belgium, we examined case data from 2000-2009. We found the increase not related to voriconazole use but most probably an high-risk patients, particularly those with underlying hematologic malignancies.
Hepatitis E virus (HEV) recently has been shown to be an antecedent infection in Guillain-Barré syndrome (GBS), but the clinical spectrum of HEV-associated GBS is not yet documented, and diagnosing acute HEV can a challenge.To determine prevalence Belgian cohort, study GBS, discuss difficulties infection.This single-center, retrospective cohort was conducted between January 1, 2007, November 2015. All patients with or variant who presented adult neurology department University Hospital...
Background Antimicrobial resistance (AMR) of Mycoplasma genitalium (MG) is a growing concern worldwide and surveillance needed. In Belgium, samples are sent to the National Reference Centre Sexually Transmitted Infections (NRC-STI) on voluntary basis representative or robust national AMR data lacking. Aim We aimed estimate occurrence resistant MG in Belgium. Methods Between July November 2022, frozen remnants MG-positive from 21 Belgian laboratories were analysed at NRC-STI. Macrolide...
Forensic microbiology is a relatively new discipline, born in part thanks to the development of advanced methodologies for detection, identification and characterization microorganisms, also relation growing impact infectious diseases iatrogenic origin. Indeed, increased application medical practices, such as transplants, which require immunosuppressive treatments, demand prosthetic installations, associated with an increasing threat antimicrobial resistance, have led rise number infections...
The aim of this verification study was to compare the QuantiFERON®-TB Gold Plus (QFT-Plus) In Tube (QFT-GIT). new QFT-Plus test contains an extra antigen tube which, according manufacturer additionally elicits a CD8+ T-cell response above CD4+ response. We assessed value in detecting recent latent tuberculosis infections.Between May 2015 and December 2016, 1031 subjects underwent QFT-GIT test. Overall agreement between both tests performance for different indications and/or immune states...
From early 2020, a high demand for SARS-CoV-2 tests was driven by several testing indications, including asymptomatic cases, resulting in the massive roll-out of PCR assays to combat pandemic. Considering dynamic viral shedding during course infection, report cycle threshold (Ct) values rapidly emerged. As Ct can be affected number factors, we considered that harmonization semi-quantitative results across laboratories would avoid potential divergent interpretations, particularly absence...
ObjectivesCefazolin is frequently administered for antimicrobial prophylaxis and treatment of infections. In neonates, pharmacokinetic observations are limited dosing regimens variable. The aim this study was to describe the pharmacokinetics cefazolin in neonates based on total unbound concentrations optimize dosing.
Although vancomycin is frequently used to treat neonatal late-onset sepsis, there no consensus on the optimal dosing regimen. Because many neonates needed adaptation due suboptimal trough values, regimen in our department was changed during 2012.We aimed document need for validation of by exploring serum levels achieved using 2 published regimens (previous regimen: based postmenstrual age and creatinine new postnatal age) identify covariates associated with (<10 mg/L).Routine therapeutic...
Abstract Background Day care centres (DCCs) are ideal settings for drug-resistant bacteria to emerge. Prevalence numbers of faecal carriage antimicrobial resistant in these rare. We aimed determine the prevalence children attending DCCs and assess identify infection risk factors within The Netherlands Belgium. Methods A point-prevalence study was conducted 28 Dutch (499 children) 18 Belgian (448 DCCs. Stool samples were taken from children’s diapers a questionnaire filled by their parents....
Mucormycosis is an angio-invasive mycosis with high morbidity and mortality rates which mainly affects immunocompromised patients. It no longer uncommon disease due to the increased incidence of diabetes use immunosuppressive agents in current era. Our objective was review all cases proven probable mucormycosis--according EORTC criteria--diagnosed from 2000 until 2007 at University Hospitals Leuven, a 1900-bed tertiary care hospital, assess changing epidemiology disease. In 45 patients there...
To determine the point prevalence of carbapenem-non-susceptible Enterobacteriaceae (CNSE) and carbapenemase-producing (CPE) isolates among hospitalized patients in Belgium.Twenty-four hospital-based laboratories prospectively collected 200 non-duplicated from clinical specimens over a 2 month period. All were screened locally for decreased susceptibility to carbapenem drugs using disc diffusion method according CLSI interpretative criteria. CNSE strains referred centrally confirmation...
To describe a novel plasmid-borne class D carbapenemase (CHDL) named OXA-427 identified in several Enterobacteriaceae clinical isolates from nine patients one Belgian hospital.OXA-427-producing were analysed by an electrochemical imipenem hydrolysis method (BYG Carba test), NP test, conventional phenotypic assays and molecular methods (PCR, whole sequencing of the OXA-427-encoding plasmid cloning). The antimicrobial resistance profile was expression cloned gene Escherichia coli DH10B...
Abstract Pulmonary Mycobacterium abscessus infection in cystic fibrosis (CF) patients is difficult to treat and considered a contra‐indication for lung transplantation most centers. We present four CF with chronic pulmonary M infection, whom was performed. Through intensive treatment before transplantation, we achieved control of the all but one patient. After mean 16 months follow up, 3 are doing well, without evidence local or disseminated recurrence. One patient died early post‐transplant...