A5050653749- Air Quality and Health Impacts
- Heart Failure Treatment and Management
- Birth, Development, and Health
- Climate Change and Health Impacts
- Health, Environment, Cognitive Aging
- Energy and Environment Impacts
- Chronic Kidney Disease and Diabetes
- Urinary Tract Infections Management
- Renal function and acid-base balance
- Electrolyte and hormonal disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Dialysis and Renal Disease Management
- Heavy Metal Exposure and Toxicity
- Acute Kidney Injury Research
- Clinical Laboratory Practices and Quality Control
- Cardiovascular Function and Risk Factors
- Platelet Disorders and Treatments
- SARS-CoV-2 and COVID-19 Research
- Potassium and Related Disorders
- Epigenetics and DNA Methylation
- Diabetes and associated disorders
- Cardiac pacing and defibrillation studies
- Liver Disease Diagnosis and Treatment
- Chronic Disease Management Strategies
- Pain Management and Treatment
Ziekenhuis Oost-Limburg
2015-2024
Hasselt University
2015-2024
Medtronic (Switzerland)
2020
Boston Scientific (Netherlands)
2020
Medtronic (United States)
2020
Biotronik (Switzerland)
2020
Abbott (Sweden)
2020
Transnational University Limburg
2016-2018
Synapse (Netherlands)
2017
Wenzhou Medical University
2017
Deborah Steensels, PharmD, PhD; Els Oris, MD; Laura Coninx, MSc, Dieter Nuyens, MD, Marie-Luce Delforge, Pieter Vermeersch, Line Heylen, PhD
Studies emphasize the importance of particulate matter (PM) in formation reactive oxygen species and inflammation. We hypothesized that these processes can influence mitochondrial function placenta fetus.We investigated PM₁₀ exposure during pregnancy on DNA content (mtDNA content) umbilical cord blood.DNA was extracted from placental tissue (n = 174) leukocytes 176). Relative mtDNA copy numbers (i.e., were determined by real-time polymerase chain reaction. Multiple regression models used to...
Abstract Background There is evidence that altered DNA methylation an important epigenetic mechanism in prenatal programming and developmental periods are sensitive to environmental stressors. We hypothesized exposure fine particles (PM 2.5 ) during pregnancy could influence patterns of the placenta. Methods In ENVIR ON AGE birth cohort, levels 5’-methyl-deoxycytidine (5-mdC) deoxycytidine (dC) were quantified placental from 240 newborns. Multiple regression models used study global utero PM...
BackgroundDevelopmental processes in the placenta and fetal brain are shaped by same biological signals. Recent evidence suggests that adaptive responses of to maternal environment may influence central nervous system development.ObjectivesWe studied association between utero exposure fine particle air pollution with a diameter ≤ 2.5 μm (PM2.5) placental expression genes implicated neural development.MethodsExpression 10 target brain-derived neurotrophic factor (BDNF) signaling pathway were...
Thyroid hormones are critical for fetal development and growth. Whether prenatal exposure to fine particle air pollution (≤ 2.5 μm; PM2.5) affects thyroid function what the impact is on birth weight in normal healthy pregnancies have not been studied yet.We of third-trimester PM2.5 maternal their mediating role weight.We measured levels free (FT3, FT4) thyroid-stimulating hormone (TSH) cord blood (n = 499) 431) collected after delivery from mother-child pairs enrolled between February 2010...
Abstract Background Exposure to cadmium has been associated with osteoporosis and fracture risk in women elderly, but studies children are lacking. In the present study we investigate association between markers of bone demineralization [urinary calcium (Ca) deoxypyridinoline (DPD) excretion] urinary (Cd) excretion (as an index lifetime body burden). Methods 155 schoolchildren from 2 elementary schools Lahore, Pakistan were included. Urinary Cd was measured as exposure. We assessed...
AbstractObjective The objective of this study was to investigate determinants the natriuretic response diuretics in decompensated heart failure (HF) and relationship with decongestion, neurohumoral activation clinical outcome contemporary era HF management.Methods results In prospective, single-centre cohort study, consecutive patients (n = 54) left ventricular ejection fraction ≤ 45% received protocol-driven diuretic therapy until complete disappearance congestion signs. Urine collected...
Background— The urinary composition, including sodium (Na + ) and chloride (Cl − concentrations, might provide useful information in addition to urine output during decongestive treatment heart failure. Methods Results— Consecutive patients with failure (n=61), ejection fraction ≤45%, worsening symptoms, scheduled intravenous loop diuretics were included. Patients received protocol-driven therapy until complete decongestion, assessed clinically by echocardiography. Three consecutive 24-hour...
Recently, a lot of research has focused on the discovery novel renal biomarkers. Among others, urinary kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) have been proven to be promising biomarkers in wide variety pathologies. However, little is known about normal concentrations urine healthy subjects. Therefore, goal our study establish reference values for KIM-1, NGAL, N-acetyl-β-D-glucosamidase (NAG), cystatin C population, taking into account possible...
Exposure to ambient particulate matter and elevated blood pressure are risk factors for cardiovascular morbidity mortality. Microvascular changes might be an important pathway in explaining the association between air pollution pressure. The objective of study was evaluate role retinal microcirculation black carbon (BC) exposure We estimated subchronic BC based on 1-week personal measurements (μ-Aethalometer, AethLabs) 55 healthy nurses. Blood microvasculature were measured four different...
Abstract Background: Urine test strip results are generally reported in categories (i.e., ordinal scaled), but automated readers now available that can report quantitative data. We investigated the possible use of these meters to complement flow cytometry urine and compared reflectance readings with determinations urinary glucose microalbumin. Methods: URISYS 2400 (Roche) data from UF-100 (Sysmex) biochemical for 436 nonpathologic pathologic samples. Results: Reproducibility signal was good...
Preservation of urine samples is important for centralised laboratory services with automated instruments.A multicentre evaluation was carried out to assess preservative tubes from BD Diagnostics-Preanalytical Systems and Greiner Bio-One test strip reading (documented at the level remission values), particle counting by flow cytometers (UF-100) visual microscopy. Failures were expressed as percentages originally positive beyond a two-fold change (+100% or -50%) original values.The...
Urinary kidney injury molecule 1 is a recently discovered early biomarker for renal damage that has been proven to be correlated urinary cadmium in rats. However, so far the association between and humans after long-term, low-dose exposure not studied. We collected urine blood samples from 153 non-smoking men women aged 60+, living an area with moderate pollution non-ferrous metal plant significant period. as well other biomarkers (alpha1-microglobulin, beta2-microglobulin, urea nitrogen,...
Fetal development largely depends on thyroid hormone availability and proper placental function with an important role played by mitochondria. The biological mechanisms which hormones exert their effects mitochondrial are not well understood. We investigated the of fetal DNA (mtDNA) content mtDNA methylation. collected tissue cord blood from 305 mother–child pairs that were enrolled between February 2010 June 2014 in ENVIRONAGE (ENVIRonmental influence ON early AGEing) birth cohort (province...
Various vaccines were developed to reduce the spread of Severe Acute Respiratory Syndrome Cov-2 (SARS-CoV-2) virus. Quickly after start vaccination, reports emerged that anti-SARS-CoV-2 vaccines, including ChAdOx1-S, could be associated with an increased risk thrombosis. We investigated hemostatic changes ChAdOx1-S vaccination in 631 health care workers. Blood samples collected 32 days on average second evaluate markers such as D-dimer, fibrinogen, α2-macroglobulin, FVIII and thrombin...
The immune response in patients with Coronavirus Disease 2019 (COVID-19) is highly variable and linked to disease severity mortality. However, antibody cytokine responses the early stage their association course outcome are still not completely understood. In this large, multi-centre cohort study, blood samples of 434 Belgian COVID-19 hospitalized different severities (ranging from asymptomatic/mild critically ill) first wave pandemic were obtained. Baseline characterized associations...
Abstract Venous congestion is an important contributor to worsening renal function in heart failure and the cardiorenal syndrome. In patients, it difficult study effects of isolated venous on organ function. this study, consequences abdominal morphology kidneys, liver were studied a rat model. Twelve sham-operated (SHAM) male Sprague Dawley rats compared eleven inferior vena cava-constricted (IVCc) for twenty-one weeks. Abdominal pressure was significantly higher IVCc versus SHAM group (p...
Background: Signs and symptoms of volume overload are the most frequent reason for hospital admission in acute heart failure (AHF). Diuretics mainstay treatment, but their optimal type dose regimen remain unclear, especially patients with cardiorenal syndrome.Methods: This prospective study aimed to include 80 AHF syndrome. Through a 2 × factorial design, were randomised towards (1) combinational treatment acetazolamide low-dose loop diuretics versus high-dose diuretics; (2) open-label oral...
<h3>Importance</h3> Exposure to ambient air pollution has been associated with the risk of carcinogenesis in later life. Changes histone modifications might have long-term adverse health effects. <h3>Objective</h3> To investigate association prenatal exposure levels circulating total H3 and specific trimethylation marks (ie, lysine 4, 36) maternal cord blood. <h3>Design, Setting, Participants</h3> The Environmental Influence on Aging (ENVIR<i>ON</i>AGE) birth cohort study included 609...