A5032252077- Renal Diseases and Glomerulopathies
- Nutritional Studies and Diet
- Renal and related cancers
- Ion Transport and Channel Regulation
- Complement system in diseases
- Rabies epidemiology and control
- Neonatal Health and Biochemistry
- Nephrotoxicity and Medicinal Plants
- Chronic Kidney Disease and Diabetes
- Electrolyte and hormonal disorders
- Disaster Response and Management
- Antimicrobial Resistance in Staphylococcus
- Streptococcal Infections and Treatments
- Renal function and acid-base balance
- Atomic and Subatomic Physics Research
- Clostridium difficile and Clostridium perfringens research
- Abdominal vascular conditions and treatments
- Vitamin D Research Studies
- Air Quality and Health Impacts
- Platelet Disorders and Treatments
- Central Venous Catheters and Hemodialysis
- Mercury impact and mitigation studies
- Vitamin C and Antioxidants Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Dialysis and Renal Disease Management
Kumamoto University
1981-2024
Harvard University
2024
Massachusetts General Hospital
2024
Kumamoto University Hospital
2022-2023
John Wiley & Sons (United States)
2018
Hudson Institute
2018
Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary leading to renal failure, wherein multiple cysts form in tubules and collecting ducts derived from distinct precursors: nephron progenitor ureteric bud (UB), respectively. Recent progress induced pluripotent stem cell (iPSC) biology has enabled cyst formation progenitor-derived human organoids which PKD1 or PKD2, major causative genes for ADPKD, are deleted. However, have not been generated UB organoids,...
Galloway-Mowat syndrome (GAMOS) is a neural and renal disorder, characterized by microcephaly, brain anomalies, early onset nephrotic syndrome. Biallelic mutations in WDR73 the 4 subunit genes of KEOPS complex are reported to cause GAMOS. Furthermore, an identical homozygous NUP107 (nucleoporin 107kDa) mutation was identified GAMOS-like families, although biallelic were originally steroid-resistant NUP133 133kDa) interacting subunits nuclear pore envelope during interphase, these proteins...
Several scoring methods for the Mediterranean diet, which is considered as a healthy are available, but studies that have compared more than one of these scores rare. In addition, applicability diet has not been sufficiently examined outside regions. We collected data on during pregnancy and incidence type 1 allergies in offspring from Japan Environment Children’s Study. Using multiple methods, we analyzed effect adherence to offspring. Overall, 46,532 pairs mothers children were analyzed....
Recent advances in stem cell research have led to the creation of organoids, miniature replicas human organs, offering innovative avenues for studying diseases. Kidney with their ability replicate complex renal structures, provide a novel platform investigating kidney diseases and assessing drug efficacy, albeit hindered by labor-intensive generation batch variations, highlighting need tailored cryopreservation methods enable widespread utilization. Here, we evaluated strategies organoids...
Key clinical message Pseudohypoaldosteronism (PHA) carries a good prognosis if treated early and appropriately, but some cases can have life‐threatening events. We underscored the need to consider secondary PHA as one of differential diagnoses hyponatremia hyperkalemia in infancy. Abstract type 1 has two classifications; primary type, caused by genetic abnormalities that develop during neonatal infancy periods, urinary tract malformation infection. Secondary PHA, prognosis; however, present...
Abstract Background Neonatal pyogenic tenosynovitis is a highly emergent soft tissue infection. We report case of neonate with tendinopathy and tendon rupture diagnosed by ultrasonography (US). He subsequently developed arthritis osteomyelitis during antimicrobial therapy. Case presentation A 7-day-old boy was admitted to our hospital redness swelling the right index finger. US on admission showed flexor finger inactivity. The day after admission, he elbow and, subsequently, osteomyelitis....
Although percutaneous renal biopsy is considered safe, this invasive procedure has complications such as arteriovenous fistula (RAVF). Even if RAVFs are not observed early after biopsy, considering the possibility of delayed hemorrhage, follow-up with ultrasound even in asymptomatic cases could be important.
Mutations of the inverted formin 2 gene (INF2), which encodes a member family, cause autosomal dominant focal segmental glomerulosclerosis (FSGS) and Charcot-Marie-Tooth (CMT) disease-associated FSGS. However, their role in idiopathic FSGS remains unclear. This study investigated INF2 localization normal adult kidney its expression children with nephrotic syndrome.We generated rabbit polyclonal antibody against conjugated peptide from human studied glomerular synaptopodin using tissues...
Vitamin D is essential for calcium absorption and bone homeostasis. Although short-stature children were reported to have low vitamin concentrations, there no clear evidence of a link between height growth in young not limited those with short stature. We collected weight data at 2 4 years age, serum concentrations years, questionnaire results on sun exposure from the Japan Environment Children’s Study (JECS). then analyzed relationship deficiency growth. also correlation concentration...
Patients undergoing dialysis care are vulnerable to disasters, because they need a guaranteed stable and large supply of tap water electricity. Although hemodialysis (HD) is an in-house treatment that relies largely on the infrastructure for electricity, supply, smooth distribution products, among other necessities, peritoneal (PD) home-based less dependent infrastructure.1Ikuto M. Toshio A. Tomoyuki Y. et al.Survey therapy during Great East Japan Earthquake Disaster recommendations...
Abstract Distinguishing between late‐onset TINU syndrome and drug‐induced AIN remains difficult given that patients with may develop uveitis long after the onset of AIN. Therefore, ophthalmic examination is required not only upon diagnosis but also continuously or when eye symptoms relapse urinary findings are observed.
Introduction: Peritonitis is a significant complication of peritoneal dialysis (PD). Additionally, in severe or prolonged cases peritonitis, the structure and function peritoneum may change, making it difficult to continue PD. Thus, identifying causative agent early administration antibiotics are essential minimize risk treatment failure. Meanwhile, bacterial peritonitis caused by nontuberculous Mycobacteria (NTM) identify. NTM also among most organisms eradicate. Oftentimes, removal...
It has been postulated that measles virus infection is associated with remission of idiopathic nephrotic syndrome (INS) in childhood. There are few reports on the correlation INS other infections. Previously, there have two case suggesting an association between influenza B and INS. The patient was 18-year-old Japanese woman. onset steroid-sensitive NS at 9 years age, pathological diagnosis minimal change (MCNS). Until 10 months prior to visiting our hospital, patient’s remission....
Alkylphenols can originate from numerous products containing alkylphenol ethoxylates, including cleaning products, household items, and cosmetics. Some phenols, such as nonylphenol, are known to be endocrine disruptors, exposure them is thought have contributed the recent increase in allergic diseases asthma. However, impacts of prenatal phenol on asthma development children still unclear.
Mercury pollution, including from its use during gold mining and refining, remains an important problem worldwide. In particular, methylmercury, a microbial alteration of mercury released into the environment, is major environmental neurotoxicant. Although there has been growing concern about health hazards exposure to low levels mercury, effects prenatal on neurodevelopmental outcomes in children have remained controversial. Japan Environment Children's Study, large-scale nationwide birth...
Abstract Hepatic IgA nephropathy is a complication of chronic liver disease. after transplantation rare, especially in children, and carries significant risk factor for renal failure mortality. In cases without viral hepatitis, steroid therapy may be useful associated with dysfunction.
続携行式腹膜透析(continuous ambulatory peritoneal dialysis: CAPD)
Abstract Background Membranoproliferative glomerulonephritis (MPGN), a rare that causes nephrotic syndrome in children, is often difficult to treat. Typical immunofluorescence findings include strong C3 staining granular pattern along the glomerular capillary wall and negative IgA staining. IgA-dominant MPGN without hypocomplementemia has been reported. Herein, we report case of with predominant subclass 2 deposits. Case presentation An 11-year-old girl showed proteinuria on school...
Abstract Patients with nephrogenic diabetes insipidus should establish a support network system by contacting the government to ensure that water can be preferentially obtained in event of disaster and create carry medical alert card.
<i>Background</i>: C1q nephropathy occurs when is significantly deposited in the mesangial region and systemic lupus erythematosus can be excluded as a diagnosis. <i>Clinical Description</i>: A case of 2-year-old boy who was diagnosed with steroid-resistant nephropathy. As he initially managed idiopathic nephrotic syndrome, prednisolone administered. However, his condition did not improve steroid treatment, other causes for were considered, including infections. it refractory to...
Congenital nephrogenic diabetes insipidus (CNDI), a rare hereditary disorder, is characterized by the inability of kidneys to concentrate urine in response antidiuretic hormone arginine vasopressin (AVP); as result, large volumes unconcentrated are excreted. In addition clinical manifestations CNDI, such dehydration and electrolyte disturbances (hypernatremia hyperchloremia), developmental delay can result without prompt treatment. approximately 90% cases, CNDI an X-linked disease caused...
Childhood-onset glomerular disease often requires ongoing treatment and follow-up into adulthood. However, few studies have analyzed the associated impact distress experienced by patients with this condition during transition from childhood to adolescence