A5006779951- Inflammatory Bowel Disease
- Microscopic Colitis
- Gastrointestinal Bleeding Diagnosis and Treatment
- Electrolyte and hormonal disorders
- Gastrointestinal disorders and treatments
- Eosinophilic Esophagitis
- Pregnancy and Medication Impact
- Parathyroid Disorders and Treatments
- Autoimmune and Inflammatory Disorders
- Renal and Vascular Pathologies
- Organ Donation and Transplantation
- Health Systems, Economic Evaluations, Quality of Life
- Immunodeficiency and Autoimmune Disorders
- Parkinson's Disease Mechanisms and Treatments
- Pharmaceutical studies and practices
- Systemic Lupus Erythematosus Research
- Hormonal Regulation and Hypertension
- Gut microbiota and health
- Biosimilars and Bioanalytical Methods
- Reproductive System and Pregnancy
- Autoimmune and Inflammatory Disorders Research
- Colorectal Cancer Screening and Detection
- Clostridium difficile and Clostridium perfringens research
- Botulinum Toxin and Related Neurological Disorders
- Gastrointestinal Tumor Research and Treatment
Clinique Jules Verne
2019-2025
Centre d'Investigation Clinique de Nantes
2016-2024
Inserm
2009-2022
Hôpital Bichat-Claude-Bernard
2013-2022
Université Paris Cité
2015-2022
Université Claude Bernard Lyon 1
2022
Digestive Health Research Institute
2016-2020
Nantes Université
2009-2019
Délégation Paris 7
2013-2018
Centre Hospitalier Universitaire de Nantes
2012-2017
Crohn's disease (CD)–associated dysbiosis could predispose patients to relapse. Gut microbiota composition of from the prospective cohort study designed identify predictive factors clinical relapse after infliximab discontinuation (STORI Study) was investigated determine impact in CD Fecal samples 33 with this were collected at baseline, 2 months, 6 and end follow-up period (19 relapsers 14 nonrelapsers). Healthy volunteers subjects (n = 29) used as a control group. The fecal assessed using...
Objective control of intestinal inflammation during inflammatory bowel disease (IBD) is becoming the main driver for medical treatment. However, monitoring tools-related burden remains poorly investigated. We aimed to evaluate their comparative acceptability and utility according patients with IBD.After a preliminary phase, final questionnaire encompassing self-administered physician questionnaires was prospectively consecutively submitted 916 IBD from 20 public private centers....
BackgroundSmall bowel capsule endoscopy is the most sensitive technique for detection of lesions in small intestine. The aims study were to assess prevalence and clinical significance jejunal detected by patients with an established Crohn's disease.
<h3>Background</h3> Enteric glial cells (EGCs) are important regulators of intestinal epithelial barrier (IEB) functions. EGC-derived <i>S</i>-nitrosoglutathione (GSNO) has been shown to regulate IEB permeability. Whether EGCs and GSNO protect the during infectious insult by pathogens such as <i>Shigella flexneri</i> is not known. <h3>Methods</h3> <i>S effects were characterised using in vitro coculture models Caco-2 (or GSNO), ex vivo human colonic mucosa, ligated rabbit loops. The effect...
Colon cancer stem cells (CSCs), considered responsible for tumor initiation and relapse, are constantly exposed to regulatory cues emanating from neighboring present in the microenvironment. Among these enteric glial (EGCs) that potent regulators of epithelium functions a healthy intestine. However, whether EGCs impact CSC-driven tumorigenesis remains unknown.Impact human EGC primary cultures or non-transformed line on CSCs isolated colon adenocarcinomas cell lines with different p53, MMR...
Crohn's disease (CD) mainly affects young adults of reproductive age. Whereas a large amount data is available concerning pregnancy in CD women, no study has been conducted on their ovarian reserve status. This aimed to investigate the potential effect women remission, as reflected by serum anti-Müllerian hormone (AMH).This retrospective case-control was University Hospital Nantes, France. Serum levels AMH were retrospectively measured 50 with remission and 163 control normal reserve,...
Inflammatory bowel diseases [IBD] are disabling disorders. The IBD-Disability Index [IBD-DI] was developed for quantifying disability in IBD patients but is difficult to use. IBD-Disk a visual adaptation of the IBD-DI. It has not been validated yet. main objectives were validate and assess clinical factors associated with change score its variability over time.From May 2018 July 2019, from three university-affiliated hospitals responded twice both IBD-DI at 3-12 month intervals. Validation...
Background.Donation after circulatory determination of death (DCDD), formerly non-heart-beating donation and cardiac death, has been re-introduced into clinical practice in France since June 2006 as a potential solution to organ shortage, but this kidney transplantation programme is not popular yet, mainly because logistical concerns uncertainty about the long-term warm ischaemia impact on transplanted kidneys.
Abstract Background and study aims Computer-aided diagnostic tools using deep neural networks are efficient for detection of lesions in endoscopy but require a huge number images. The impact the quality annotation has not been tested yet. Here we describe multi-expert annotated dataset images extracted from capsules Crohn’s disease patients annotations on accuracy recurrent attention network. Methods Images capsule were by reader first then reviewed three experts inflammatory bowel disease....
The value of estimated glomerular filtration rate (eGFR) in living kidney donors screening is unclear. A recently published web-based application derived from large cohorts, but not donors, calculates the probability a measured GFR (mGFR) lower than determined threshold. Our objectives were to validate clinical utility this tool cohort and test two other strategies based on chronic disease epidemiology collaboration (CKD-EPI) MDRD-eGFR. was using 51Cr- ethylene-diamine tetraacetic acid...
Shigella, an enteroinvasive bacteria induces a major inflammatory response responsible for acute rectocolitis in humans. However, early effect of Shigella flexneri (S. flexneri) infection upon the human mucosa and its microenvironement, particular enteric nervous system, remains currently unknown. Therefore, this study, we sought to characterize ex vivo events shigellosis model colonic explants. In particular, aimed at identifying factors produced by S. lesions barrier. We also determining...
Early detection is an essential prognostic factor in colorectal cancer (CRC) recurrence. Our aim was to evaluate diagnostic performances of (18)F-fluorodeoxyglucose-positron emission tomography ((18)F-FDG-PET)/computed (CT) as compared with CT the CRC recurrence.Data patients suspected recurrence and whom both FDG-PET/CT were performed analyzed. All detected lesions characterized according their number, size, localization. Positive histological or radiological follow-up considered 'gold...
Aims In patients with ulcerative colitis (UC), no biomarker is available to help the physician choose most suitable biotherapy. The primary objective of this pilot study was assess feasibility identification α4β7- and TNF-expressing cells, predict response vedolizumab using confocal laser endoscopy (CLE). Methods Patients moderate-to-severe UC, naïve biotherapy, received vedolizumab. Clinical evaluation performed at each infusion. Endoscopic before inclusion week 22. Fresh colonic biopsies...
Abstract Background Inflammatory Bowel Diseases (IBD) affect psychological, family, social and professional dimensions of patients’ life, leading to disability which is essential quantify as part Patient-Reported Outcomes (PROs) newly included in the targets reach IBD patients. Up now, IBD-Disability Index (IBD-DI) was only validated tool assess disability, but it not appropriate for use clinical practice. The Disk developed, a shortened self-administered tool, adapted from IBD-DI, order...