A5051974849- Diet and metabolism studies
- GDF15 and Related Biomarkers
- Nutrition and Health in Aging
- Heart Failure Treatment and Management
- Diabetes Treatment and Management
- Adipose Tissue and Metabolism
- Cardiovascular Function and Risk Factors
- Pancreatic function and diabetes
- Adipokines, Inflammation, and Metabolic Diseases
- Health, Medicine and Society
- Muscle metabolism and nutrition
- Cardiomyopathy and Myosin Studies
- Birth, Development, and Health
- Exercise and Physiological Responses
- Liver Disease Diagnosis and Treatment
- Nuclear Receptors and Signaling
Institut des Maladies Métaboliques et Cardiovasculaires
2023-2025
Inserm
2023-2025
Université de Toulouse
2025
Université Toulouse III - Paul Sabatier
2023-2024
Abstract The 5/6 nephrectomy and adenine-induced nephropathy mouse models have been extensively used to study Chronic Kidney Disease (CKD)-related cachexia. One common caveat of these CKD is the cross-sectional nature comparisons made versus controls. We here performed a comprehensive longitudinal assessment body composition energy metabolism in both models. most striking finding that weight loss largely driven by reduced food intake which promotes rapid lean fat mass. However, models, mice...
Type 2 diabetes (T2D) and obesity are strongly associated with low natriuretic peptide (NP) plasma levels a down-regulation of NP guanylyl cyclase receptor-A (GCA) in skeletal muscle adipose tissue. However, no study has so far provided evidence for causal link between atrial (ANP)/GCA deficiency T2D pathogenesis. Here, we show that both systemic ANP/GCA deficiencies mice promote metabolic disturbances prediabetes. Skeletal insulin resistance is further altered mitochondrial function...
Growth and differentiation factor 15 (GDF15) has recently emerged as a weight loss insulin-sensitizing factor. Growing evidence also supports role for GDF15 physiological, exercise-induced stress signal. Here, we tested whether is required the effects of exercise in mice humans. At baseline, both under standard nutritional state high-fat feeding, knockout (KO) display normal glucose tolerance, systemic insulin sensitivity, maximal speed, endurance running capacity when compared to wild-type...
Abstract Skeletal muscle plays a central role in the regulation of systemic metabolism during lifespan. With aging, mediated metabolic homeostasis is perturbed, contributing to onset multiple chronic diseases. Our knowledge on mechanisms responsible for this age-related perturbation limited, as it difficult distinguish between correlation and causality molecular changes aging. Glycerophosphocholine phosphodiesterase 1 (GPCPD1) highly abundant enzyme hydrolysis lipid glycerophosphocholine...
Background: Cachexia is a typical feature of Chronic Kidney Disease (CKD) and the resulting muscle wasting strongly associates with mortality in humans.Methods: The 5/6 nephrectomy adenine-induced nephropathy mouse models have been extensively used to study pathophysiology CKD-related cachexia. One common caveat these CKD cross-sectional nature comparisons made versus controls. We here performed comprehensive longitudinal assessment body composition energy metabolism both models.Findings:...