A5056380260- Caveolin-1 and cellular processes
- Health Systems, Economic Evaluations, Quality of Life
- Heart Failure Treatment and Management
- Gene expression and cancer classification
- Hippo pathway signaling and YAP/TAZ
- Cellular Mechanics and Interactions
- Erythrocyte Function and Pathophysiology
- Metabolomics and Mass Spectrometry Studies
- Molecular Biology Techniques and Applications
- RNA Research and Splicing
- Gene Regulatory Network Analysis
- Cardiac pacing and defibrillation studies
- Chronic Disease Management Strategies
- Cancer-related molecular mechanisms research
- Microtubule and mitosis dynamics
- Bioinformatics and Genomic Networks
Spanish National Centre for Cardiovascular Research
2017-2024
Despite their emerging relevance to fully understand disease pathogenesis, we have as yet a poor understanding how biomechanical signals are integrated with specific biochemical pathways determine cell behaviour. Mesothelial-to-mesenchymal transition (MMT) markers colocalized TGF-β1-dependent signaling and yes-associated protein (YAP) activation across biopsies from different pathologies exhibiting peritoneal fibrosis, supporting mechanotransduction central driving component of these class...
Abstract Omic science is rapidly growing and one of the most employed techniques to explore differential patterns in omic datasets principal component analysis (PCA). However, a method enlighten network features that mostly contribute sample separation obtained by PCA missing. An alternative build correlation networks between univariately-selected significant features, but this neglects multivariate unsupervised feature compression responsible for segregation. Biologists medical researchers...
Caveolae are nanoscopic and mechanosensitive invaginations of the plasma membrane, essential for adipocyte biology. Transmission electron microscopy (TEM) offers highest resolution caveolae visualization, but provides complicated images that difficult to classify or segment using traditional automated algorithms such as threshold-based methods. As a result, time-consuming tasks localization quantification currently performed manually. We used Keras library in R train convolutional neural...
Adipocytes expand massively to accommodate excess energy stores and protect the organism from lipotoxicity. Adipose tissue expandability is at center of disorders such as obesity lipodystrophy; however, little known about relevance adipocyte biomechanics on etiology these conditions. Here, we show in male mice vivo that plasma membrane undergoes caveolar domain reorganization upon lipid droplet expansion. As grows, caveolae disassemble release their reservoir increase cell surface area,...