A5009152570- Caveolin-1 and cellular processes
- Erythrocyte Function and Pathophysiology
- Hippo pathway signaling and YAP/TAZ
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
Spanish National Centre for Cardiovascular Research
2022-2024
Caveolae are nanoscopic and mechanosensitive invaginations of the plasma membrane, essential for adipocyte biology. Transmission electron microscopy (TEM) offers highest resolution caveolae visualization, but provides complicated images that difficult to classify or segment using traditional automated algorithms such as threshold-based methods. As a result, time-consuming tasks localization quantification currently performed manually. We used Keras library in R train convolutional neural...
Adipocytes expand massively to accommodate excess energy stores and protect the organism from lipotoxicity. Adipose tissue expandability is at center of disorders such as obesity lipodystrophy; however, little known about relevance adipocyte biomechanics on etiology these conditions. Here, we show in male mice vivo that plasma membrane undergoes caveolar domain reorganization upon lipid droplet expansion. As grows, caveolae disassemble release their reservoir increase cell surface area,...