A5015229477- Neuroscience and Neuropharmacology Research
- Poxvirus research and outbreaks
- Tryptophan and brain disorders
- PARP inhibition in cancer therapy
- Pluripotent Stem Cells Research
- Chemotherapy-induced cardiotoxicity and mitigation
- Electrocatalysts for Energy Conversion
- Bacteriophages and microbial interactions
- Stress Responses and Cortisol
- RNA and protein synthesis mechanisms
- Cardiomyopathy and Myosin Studies
- Supercapacitor Materials and Fabrication
- CRISPR and Genetic Engineering
- CAR-T cell therapy research
- Cancer Treatment and Pharmacology
- Bacillus and Francisella bacterial research
- RNA Research and Splicing
- Membrane-based Ion Separation Techniques
- COVID-19 Clinical Research Studies
- PI3K/AKT/mTOR signaling in cancer
- Membrane Separation Technologies
- Nanoparticle-Based Drug Delivery
- Neuroscience and Neural Engineering
- Herpesvirus Infections and Treatments
- BRCA gene mutations in cancer
Chongqing Medical University
2018-2025
University of British Columbia
2018-2025
Affiliated Hospital of Southwest Medical University
2024
Zhongkai University of Agriculture and Engineering
2021
Chongqing University
2018
East China University of Science and Technology
2012-2015
Abstract Chronic stressful occurrences are documented as a vital cause of both depression and anxiety disorders. However, the stress-induced molecular mechanisms underlying common distinct pathophysiology these disorders remains largely unclear. We utilized chronic mild stress (CMS) rat model to differentiate subgroup depression-susceptible, anxiety-susceptible, insusceptible rats. The hippocampus was analyzed for differential proteomes by combining mass spectrometry isobaric tags relative...
Ibrutinib (IB) is an oral Bruton's tyrosine kinase (BTK) inhibitor that has demonstrated benefit in B cell cancers, but associated with a dramatic increase atrial fibrillation (AF). We employed cell-specific differentiation protocols and optical mapping to investigate the effects of IB other inhibitors (TKIs) on voltage calcium transients ventricular human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs). direct hPSC-CMs would be predicted predispose AF. Second-generation BTK did not...
Abstract Doxorubicin is a potent anticancer drug used to treat variety of cancer types. However, its use limited by doxorubicin-induced cardiotoxicity (DIC). A missense variant in the RARG gene (S427L; rs2229774) has been implicated susceptibility DIC genome wide association study. The goal this study was investigate functional role DIC. We induced pluripotent stem cell derived cardiomyocytes (iPSC-CMs) from patients treated with doxorubicin. iPSC-CMs individuals who experienced (cases)...
BACKGROUND: Protein-truncating mutations in the titin gene are associated with increased risk of atrial fibrillation. However, little is known about underlying pathophysiology. METHODS: We identified a heterozygous truncating variant (TTNtv) patient unexplained early onset fibrillation and normal ventricular function. generated patient-specific atrial- ventricular-like induced pluripotent stem cell-derived cardiomyocytes engineered heart tissue to evaluate impact TTNtv on electrophysiology,...
Doxorubicin is a commonly used chemotherapeutic drug, but its use limited by doxorubicin-induced cardiotoxicity (DIC), which can lead to irreversible heart failure and death. A missense variant rs2229774 (p.S427L) in the retinoic acid receptor gamma (RARG) gene associated with increased susceptibility DIC, precise mechanism underlying this association incompletely understood. We performed molecular dynamic simulations determine effect of on RARG structure then validated these predictions...
Despite studies providing insight into the neurobiology of chronic stress, depression and anxiety, long noncoding RNA (lncRNA)-mediated mechanisms underlying common distinct pathophysiology these stress-induced disorders remain nonconclusive. In a previous study, we used mild stress paradigm to separate depression-susceptible, anxiety-susceptible insusceptible rat subpopulations. current lncRNA messenger (mRNA) expression was comparatively profiled in hippocampus three groups using...
A lock-in strategy applicable to proteomic analysis of corona complexes bound amino-free ligands gold nanoparticles.
Abstract Nanoporous carbon/graphene composites (NCGC) are synthesized via one‐step hydrothermal approach combining carbonization, where phenol and formaldehyde used as carbon sources triblock copolymers F127 template. Transmission electron microscopy (TEM) nitrogen adsorption measurements show that the NCGC samples possess high surface area over 400 m 2 ·g −1 mesoporous structures with interconnected pores. The electrochemical studies demonstrate Pt catalyst support exhibits better...
Abstract The current monkeypox outbreak has caused over 64,000 global cases, but the effective treatments are very limited. dual specific phosphatase (H1) from antagonizes immune response and is crucial for viral replication, making it an attractive antiviral target. Here we determined a 1.8-Å crystal structure of H1, which forms domain swapped dimer resembling butterfly. Each active site, consists Cys-Arg-Asp triad, captures phosphate ion. observed conformation mimics final step catalysis...
In 2023, an estimated 28,400 Canadian women will be diagnosed with breast cancer, and 5,400 die of it. Genetic mutations in BRCA1, BRCA2, other genes have been linked to increased risk developing this disease. testing can used identify genetic evaluate the inherited factors for preventative purposes. This approach is especially important high-risk groups, including individuals Ashkenazi Jewish descent, who are 10 times more likely carry a BRCA gene mutation.
Abstract Background Protein truncating mutations in the titin gene are associated with increased risk of atrial fibrillation (AF). However, little is known regarding underlying pathophysiology. Methods We identified a heterozygous variant patient unexplained early-onset AF using whole exome sequencing. used and ventricular induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs), CRISPR/Cas9 genetic correction, engineered heart tissue (EHT) constructs to evaluate impact on...