A5010323366- Epigenetics and DNA Methylation
- Hepatitis B Virus Studies
- Infrastructure Maintenance and Monitoring
- Structural Integrity and Reliability Analysis
- Liver Disease Diagnosis and Treatment
- Concrete Corrosion and Durability
- Flood Risk Assessment and Management
- Drilling and Well Engineering
- Geotechnical Engineering and Underground Structures
- Tropical and Extratropical Cyclones Research
- Water Systems and Optimization
- Innovations in Concrete and Construction Materials
- BIM and Construction Integration
- Mineral Processing and Grinding
- Concrete and Cement Materials Research
- Infrastructure Resilience and Vulnerability Analysis
- Metallurgy and Material Forming
- Ocular Infections and Treatments
- Non-Destructive Testing Techniques
- Structural Engineering and Vibration Analysis
- Rheology and Fluid Dynamics Studies
- Geomechanics and Mining Engineering
- Ocular Surface and Contact Lens
- Structural Behavior of Reinforced Concrete
- Smart Materials for Construction
Purdue University West Lafayette
2022-2025
Chongqing Medical University
2024-2025
North Dakota State University
2023-2024
Florida A&M University - Florida State University College of Engineering
2023
Beijing Institute of Genomics
2020-2022
University of Chinese Academy of Sciences
2022
Chinese Academy of Sciences
2020-2022
National Energy Technology Laboratory
2019-2021
Oak Ridge Associated Universities
2020
Oak Ridge Institute for Science and Education
2020
Abstract Background Abnormal DNA methylation is a hallmark of human cancers and may be promising biomarker for early diagnosis cancers. However, the majority biomarkers that have been identified are based on hypothesis differential regions (DMRs) maintained throughout carcinogenesis could detected at all stages cancer. Methods In this study, we potential colorectal cancer (CRC) development by genome-wide assay (Illumina infinium450, 450 K) normal ( N = 20) pre-colorectal samples including 18...
Purpose: Ocular surface microbiome changes can affect meibomian gland dysfunction (MGD) development. This study aimed to delineate differences among the of eyelid skin, conjunctiva, and meibum in healthy controls (HCs) patients afflicted with MGD. Methods: Shotgun metagenomic analysis was used determine if there are between microbial communities ocular sites surrounding individuals Results: The bacterial content these microbiomes dissimilar two different types individuals. Almost all most...
Circulating cell-free DNA (cfDNA) methylation has been demonstrated to be a promising approach for non-invasive cancer diagnosis. However, the high cost of whole genome bisulfite sequencing (WGBS) hinders clinical implementation methylation-based cfDNA early detection biomarker. We proposed novel strategy in low-pass WGBS (~ 5 million reads) detect changes circulating from patients with liver diseases and hepatocellular carcinoma (HCC).The effective small depth were determined by pilot...
Abstract As the best adapted high altitude population, Tibetans feature a relatively offspring survival rate. Genome-wide studies have identified hundreds of candidate SNPs related to adaptation Tibetans, although most them unknown functional relevance. To explore mechanisms behind successful reproduction at altitudes, we compared placental transcriptomes sea level Hans (SLHan), and Han immigrants (ImHan). Among three populations, placentas from ImHan showed hyperactive gene expression...
Composite reinforcements are attracting attention in the reinforced concrete (RC) field for their high corrosion resistance, low thermal conductivity, and electromagnetic interference behavior. However, compared to metallic reinforcements, composites less ductile may lead brittle failure. Three-point flexural tests provide information on mechanical behavior of metal- composite-reinforced beams with distinct crack patterns. The structural conditions failure mechanisms can be defined based...
High-risk human papillomavirus (HPV) replication requires deregulation of host DNA damage response (DDR) and inflammatory pathways. topoisomerase 2β (Top2β) was previously shown to promote HPV replication, while the function its paralog Top2α in viral life cycle remains unknown. Elevated levels are consistently observed cervical intraepithelial lesions related carcinomas, as well HPV-positive cell lines. Silencing with shRNA severely suppresses genome maintenance amplification, but a...
Understanding the rheological behavior of cement slurries is important in and petroleum industries. In this paper, we study fully developed flow a slurry inside wellbore. The modeled as non-linear fluid, where constitutive relation for viscous stress tensor based on modified form second grade (Rivlin–Ericksen) fluid used;we also propose diffusion flux vector concentration particles. one-dimensional forms governing equations boundary conditions are made dimensionless solved numerically. A...
Abstract This article presents a novel application of metaheuristic optimization and rating techniques to virtual test results for cement mortar, objective computational methods the evaluation selection cementitious materials based on simulated material testing. A scalable approach particle swarm National Institute Standards Technology Virtual Cement Concrete Testing Laboratory (VCCTL) is successfully demonstrated using ∼150,000 combinations phase distributions water‐to‐cement ratios, with...
Additives such as nano-silica and fly ash are widely used in cement concrete materials to improve the rheology of fresh performance hardened increase sustainability industry by reducing usage Portland cement. Therefore, it is important study effect these additives on rheological behavior In this paper, we pulsating Poiseuille flow a horizontal pipe considering two different when they combined (nano-silica, ash, nano-silica, ash). To model suspension, modified form power-law demonstrate...
The locked wheel skid tester (LWST) has the capability to perform efficient on-site pavement resistance tests without traffic control. A LWST friction test measures longitudinal force and vertical load taking place at tire–pavement interface of a standard specified speed. However, is only for straight level pavements. Possible reasons that may fail provide reliable data during vehicle cornering are biased tire speed measurements, missing information side friction, risky trailer fishtailing....
In this paper we study the buoyancy driven flow of a particulate suspension between two inclined walls. The is modeled as non-linear fluid, where (shear) viscosity depends on concentration (volume fraction particles) and shear rate. motion particles determined by convection-diffusion equation. equations are made dimensionless boundary value problem solved numerically. A parametric performed, velocity, temperature profiles obtained for various values numbers. numerical results indicate that...