A5101473353- Cancer Genomics and Diagnostics
- Plant Genetic and Mutation Studies
- RNA modifications and cancer
- Advanced biosensing and bioanalysis techniques
- Epigenetics and DNA Methylation
- RNA and protein synthesis mechanisms
- Cancer-related molecular mechanisms research
- CRISPR and Genetic Engineering
- Atomic and Subatomic Physics Research
- Plant Virus Research Studies
- RNA Research and Splicing
- MicroRNA in disease regulation
- Alzheimer's disease research and treatments
- Genomics and Phylogenetic Studies
- Acute Myeloid Leukemia Research
- Diet and metabolism studies
- Electroconvulsive Therapy Studies
- Biomedical Text Mining and Ontologies
- Functional Brain Connectivity Studies
- Memory and Neural Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurobiology and Insect Physiology Research
- Neuroscience and Neuropharmacology Research
- Radiomics and Machine Learning in Medical Imaging
- Garlic and Onion Studies
Huazhong University of Science and Technology
2023-2025
Peking University
2023-2025
Peking University Cancer Hospital
2023-2025
Xuzhou Medical College
2024
West China Hospital of Sichuan University
2023
Sichuan University
2023
Chongqing Medical University
2021-2022
Rice Research Institute
2015
Shenyang Agricultural University
2015
Abstract Sleep, locomotor and social activities are essential animal behaviors, but their reciprocal relationships underlying mechanisms remain poorly understood. Here, we elicit information from a cutting-edge large-language model (LLM), generative pre-trained transformer (GPT) 3.5, which interprets 10.2–13.8% of Drosophila genes known to regulate the 3 behaviors. We develop an instrument for simultaneous video tracking multiple moving objects, conduct genome-wide screen. have identified...
Abstract As one of the most crucial post-translational modifications (PTMs), protein phosphorylation regulates a broad range biological processes in eukaryotes. Biocuration, integration and annotation reported events will deliver valuable resource for community. Here, we present an updated database, eukaryotic site database 2.0 (EPSD 2.0), which includes 2,769,163 experimentally identified sites (p-sites) 362,707 phosphoproteins from 223 From literature, 873,718 new p-sites through...
Gastric cancer is the fifth most common globally and associated with significant morbidity mortality. Despite its alarming prevalence, limited comparative evidence exists on treatment efficacy prognosis across diverse China populations. To address this, our study used a large-scale dataset from National Cancer Information Database, including data 220,304 patients 53 leading hospitals 27 provinces in China. From 2017 to 2023, early-stage (Stages I-II) gastric diagnoses increased 35.63% of all...
Despite studies providing insight into the neurobiology of chronic stress, depression and anxiety, long noncoding RNA (lncRNA)-mediated mechanisms underlying common distinct pathophysiology these stress-induced disorders remain nonconclusive. In a previous study, we used mild stress paradigm to separate depression-susceptible, anxiety-susceptible insusceptible rat subpopulations. current lncRNA messenger (mRNA) expression was comparatively profiled in hippocampus three groups using...
The mechanisms behind a lack of efficient fear extinction in some individuals are unclear. Here, by employing principal components analysis (PCA)-based approach, we differentiated the mice into extinction-resistant and susceptible groups. We identified that elevated synapsin 2a (Syn2a) infralimbic cortex (IL) to basolateral amygdala (BLA) circuit disrupted presynaptic orchestration, leading an excitatory/inhibitory imbalance BLA region causing resistance. Overexpression or silencing Syn2a...
CRISPR-based screens have discovered novel functional genes involving in diverse tumor biology and elucidated the mechanisms of cancer pathological states. Recently, with its randomness unbiasedness, CRISPR been used to discover effector previously unknown roles for AML. Those targets are related AML survival resembled cellular pathways mediating epigenetics, synthetic lethality, transcriptional regulation, mitochondrial energy metabolism. Other that crucial pharmaceutical targeting drug...
摘要:
Abstract Squamous cervical cancer (SCC) is a major cause of death in women, yet its molecular characteristics are poorly understood. Here, we profiled histopathological and alterations SCC, used large language models (LLMs) for interpretation, reasoning, understanding multi-modal data. We implemented an immersive-knowledge prompting (iKLP) strategy to trigger LLMs, which interpreted 17.8%-20.3% omic known be associated with cancer. Also, the emergence cross-disciplinary reasoning LLMs helped...