Li Yuan

ORCID: 0000-0002-0373-788X
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About
Contact & Profiles
Research Areas
  • Congenital heart defects research
  • Angiogenesis and VEGF in Cancer
  • RNA regulation and disease
  • Venous Thromboembolism Diagnosis and Management
  • Inflammatory Bowel Disease
  • Cancer-related gene regulation
  • Biomedical Text Mining and Ontologies
  • Ferroptosis and cancer prognosis
  • Coal Combustion and Slurry Processing
  • IL-33, ST2, and ILC Pathways
  • Gastric Cancer Management and Outcomes
  • Cancer Genomics and Diagnostics
  • interferon and immune responses
  • Lipid metabolism and disorders
  • Diagnosis and Treatment of Venous Diseases
  • CRISPR and Genetic Engineering
  • Cancer-related molecular mechanisms research
  • Helicobacter pylori-related gastroenterology studies
  • Landfill Environmental Impact Studies
  • Lymphatic System and Diseases
  • Recycling and utilization of industrial and municipal waste in materials production
  • Acute Ischemic Stroke Management

Chongqing Cancer Hospital
2023-2024

Chongqing University
2023-2024

Shanxi Academy of Medical Sciences
2023

Shanxi Medical University
2023

Huazhong University of Science and Technology
2021-2023

Tongji Hospital
2021-2023

Herlev Hospital
2017

University of Copenhagen
2017

Collège de France
2005

Inserm
2005

Targeted therapies represent attractive combination partners with immune checkpoint blockade (ICB) to increase the population of patients who benefit or interdict emergence resistance. We demonstrate that targeting WEE1 up-regulates signaling through double-stranded RNA (dsRNA) viral defense pathway subsequent responsiveness even in cGAS/STING-deficient tumors, which is a typical phenotype across multiple cancer types. inhibition increases endogenous retroviral elements (ERVs) expression by...

10.1084/jem.20210789 article EN cc-by-nc-sa The Journal of Experimental Medicine 2021-11-26

Gastric cancer is a type of digestive tract with high morbidity and mortality, which leads to major health burden worldwide. More research into the functions immune system will improve therapy survival in gastric patients. We attempted identify potential biomarkers or targets via bioinformatical analysis approaches. Three gene expression profile datasets (GSE79973, GSE103236, GSE118916) tissue samples were obtained from Gene Expression Omnibus database. There 65 overlapping differentially...

10.4103/cjop.cjop-d-22-00078 article EN cc-by-nc-sa The Chinese Journal of Physiology 2023-03-01

Abstract Crohn’s disease is associated with an altered innate immune response of pathogenic importance. This can be to loss-of-function polymorphisms in the NOD2 (nucleotide-binding oligomerization domain-containing protein 2) gene, but also changes transcriptional and post-transcriptional regulatory layers, including microRNA activity. Here, we characterized link between genotype inflammatory-mediated signaling by studying activity NOD2-agonist muramyl dipeptide monocytes from healthy...

10.1038/s41525-016-0001-4 article EN cc-by npj Genomic Medicine 2017-02-08

Stickiness is a phenomenon observed widely in sludge drying practices, which negatively impacts the efficiency. This paper was aimed at evaluating stickiness characteristics of when sand content increases during rainy season, and carrying out modification experiments on high sludge. The results indicated that significantly positively correlated with During process, adhesion force cohesion decreased increase temperature, consistently greater than every group. reduced after ultrasonic...

10.1080/07373937.2024.2419000 article EN Drying Technology 2024-10-24

Postoperative venous thromboembolism (VTE) is a potentially life-threatening complication. This study aimed to develop predictive model identify independent risk factors and estimate the likelihood of VTE in patients undergoing surgery for cervical cancer.

10.1186/s12957-024-03649-2 article EN cc-by-nc-nd World Journal of Surgical Oncology 2024-12-31

Abstract Squamous cervical cancer (SCC) is a major cause of death in women, yet its molecular characteristics are poorly understood. Here, we profiled histopathological and alterations SCC, used large language models (LLMs) for interpretation, reasoning, understanding multi-modal data. We implemented an immersive-knowledge prompting (iKLP) strategy to trigger LLMs, which interpreted 17.8%-20.3% omic known be associated with cancer. Also, the emergence cross-disciplinary reasoning LLMs helped...

10.21203/rs.3.rs-2855719/v1 preprint EN cc-by Research Square (Research Square) 2023-05-30
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