A5061783786- Ferroptosis and cancer prognosis
- Advanced Glycation End Products research
- Diabetes Treatment and Management
- Cancer, Lipids, and Metabolism
- Drug Transport and Resistance Mechanisms
- Chronic Kidney Disease and Diabetes
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Atherosclerosis and Cardiovascular Diseases
- Pancreatic function and diabetes
- Peptidase Inhibition and Analysis
- RNA Research and Splicing
- Metabolism, Diabetes, and Cancer
- Epigenetics and DNA Methylation
- Cell death mechanisms and regulation
- Sepsis Diagnosis and Treatment
- MicroRNA in disease regulation
- Pancreatic and Hepatic Oncology Research
- Acute Kidney Injury Research
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer Mechanisms and Therapy
- Dialysis and Renal Disease Management
- Lipoproteins and Cardiovascular Health
- Infective Endocarditis Diagnosis and Management
Dalian Medical University
2022-2025
Chongqing Medical University
2022-2025
Second Affiliated Hospital of Chongqing Medical University
2022-2025
Reactive oxidative species (ROS) production-driven ferroptosis plays a role in acute kidney injury (AKI). However, its exact molecular mechanism is poorly understood. Scavenger receptor CD36 has important roles oxidizing lipids, lipid accumulation, metabolic syndrome, and insulin resistance chronic disease, but remain unexplored AKI. The present study investigated the of regulating proximal tubular cell expression was found to be significantly up-regulated AKI renal tissues correlated with...
Atherosclerosis and vessel wall trauma induce vascular smooth muscle cell (VSMC) phenotypic modulation, leading to plaque cap growth postintervention restenosis. Our systems biology approach identified RNA binding protein, mRNA processing factor ( RBPMS ) as a conserved, VSMC-specific gene associated with VSMC modulation in atherosclerosis. expression positively correlates contractile markers human murine atherosclerotic arteries well two injury models during the postinjury intimal...
Hypertensive nephropathy (HTN) is a common complication of hypertension. Although various agents for treatment hypertension exert significant effects, there currently no effective hypertensive nephropathy. Sodium-glucose cotransporter 2 (SGLT2) inhibitors, such as dapagliflozin (DAPA), are new class hypoglycemic shown to improve the prognosis patients with chronic kidney disease and diabetes mellitus. However, mechanisms underlying protective effects DAPA remain unclear. RNA-sequencing...
Sodium-glucose co-transporter-2 inhibitor (SGLT2i) are antihyperglycemic medications that reduce cardiovascular disease (CVD) and improve chronic kidney prognosis in patients with diabetes mellitus. The specific impact of SGLT2i treatment on hypertensive individuals, however, remains to be established. This underscores the need for systematic efforts profile molecular landscape associated administration.We conducted a detailed RNA-sequencing (RNA-Seq)-based exploration transcriptomic changes...
Abstract Ferroptosis, characterized by lipid accumulation in intracellular compartments, is related to acute kidney injury (AKI), but the mechanism remains obscure. In our previous study, protective effect of augmenter liver regeneration (ALR) on AKI was not fully clarified. this we established an mouse model knocking out proximal tubule‐specific ALR and cell inducing hypoxia, as well enrolled patients, investigate effects ferroptosis progression AKI. We found that knockout aggravated...
Necroptosis plays an important role in the pathogenesis of acute kidney injury (AKI), and necroptosis-related interventions may therefore be measure for treatment AKI. Our previous study has shown that augmenter liver regeneration (ALR) inhibits renal tubular epithelial cell apoptosis regulates autophagy; however, influence ALR on necroptosis remains unclear. In this study, we investigated effect caused by ischemia-reperfusion underlying mechanism. vivo experiments indicated kidney-specific...
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An early and accurate diagnosis of septic cardiomyopathy is vital for improving the overall prognosis sepsis. In our research, we aimed to identify signature genes their immune connections in cardiomyopathy. By analyzing mouse myocardial transcriptome from sepsis induced by cecum ligation puncture (CLP), identified four distinct k-means clusters. Further analysis human datasets using Weighted Gene Co-expression Network Analysis (WGCNA) revealed a strong correlation between MEturquoise module...
Abstract Background Ferroptosis, characterized by lipid accumulation in intracellular compartments, is related to acute kidney injury (AKI), but the mechanism remains obscure. In our previous study, we reported important roles for augmenter of liver regeneration (ALR) antioxidant mechanisms. However, ALR ferroptosis, especially morphological changes mitochondria induced this type regulated cell death, remain unclear and warrant further investigation. Methods We subjected Kidney-specific...