A5102324774- Inflammatory Bowel Disease
- Cancer-related molecular mechanisms research
- Nanoplatforms for cancer theranostics
- Circular RNAs in diseases
- COVID-19 Clinical Research Studies
- Cancer, Hypoxia, and Metabolism
- COVID-19 and healthcare impacts
- Advanced Nanomaterials in Catalysis
- RNA modifications and cancer
- Wnt/β-catenin signaling in development and cancer
- Nanocluster Synthesis and Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Immune Response and Inflammation
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Reproductive System and Pregnancy
- Ovarian cancer diagnosis and treatment
- Long-Term Effects of COVID-19
- Peroxisome Proliferator-Activated Receptors
- Sulfur Compounds in Biology
- Infectious Diseases and Mycology
- FOXO transcription factor regulation
- Ferroptosis and cancer prognosis
- Amino Acid Enzymes and Metabolism
- Cancer, Stress, Anesthesia, and Immune Response
Chongqing Medical University
2016-2025
Second Affiliated Hospital of Chongqing Medical University
2016-2025
Dalian Medical University
2016-2025
Army Medical University
2012-2014
Gastric cancer (GC) is the fifth most prevalent type of malignancy and third leading cause cancer‑related mortality worldwide, with prognosis patients late‑stage GC remaining at poor levels. Long non‑coding RNA (lncRNA) H19 (H19) involved in growth metastasis tumors, it upregulated under hypoxic conditions certain types cancer; however, underlying mechanisms action this lncRNA as regards initiation development remain unknown. Thus, present study, we aimed to determine role elucidate...
Hepatocellular carcinoma (HCC) is the most common type of liver cancer worldwide, and it second leading cause cancer-related mortality. Aquaporin 9 (AQP9) an essential aquaporin in located basolateral membrane hepatocytes, but its roles on HCC has not been completely elucidated. This study investigated regulatory functions AQP9 pathogenesis HCC. The expression levels were significantly down-regulated tissues cells, which was also correlated with tumor size number, TNM stage, five-year...
Background/Aims: Development of effective therapeutic drugs for Parkinson's disease is in great need. During the progression disease, Rho-associated protein kinase 2 (ROCK2) activated to promote neurodegeneration. Hydrogen sulfide (H2S) has a neuroprotective effect during neural injury disease. However, mechanisms that underlie effects ROCK2 and H2S remain ill-defined. In current study, we addressed these questions. Methods: We used 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced...
Ulcerative colitis (UC) is a chronic and recurrent digestive tract disease that can lead to significant morbidity mortality. The pathogenesis of UC intricately associated with the presence reactive oxygen species (ROS). Prussian blue (PB), an inorganic nanozyme potent antioxidant properties, has been extensively applied in treatment various inflammatory conditions tumors. However, despite explicit underlying molecular mechanism PB remains poorly understood. Furthermore, there deficiency...
Hepatocellular carcinoma (HCC) is one of the most common types cancer, which associated with a poor prognosis. It necessary to identify novel prognostic biomarkers and therapeutic targets improve survival patients HCC. In present study, seven‑gene signature HCC progression was identified using weighted gene co‑expression network analysis least absolute shrinkage selection operator, its prediction value confirmed in The Cancer Genome Atlas‑liver International Consortium liver cancer‑RIKEN,...
Metastasis of hepatocellular carcinoma (HCC) critically impacts the survival prognosis patients, with pivotal role stem cells in initiating invasive metastatic behaviors. The Flap Endonuclease 1 (FEN1) is delineated as a metallonuclease, quintessential for myriad cellular processes including DNA replication, synthesis, damage rectification, Okazaki fragment maturation, baseexcision repair, and preservation genomic stability. Furthermore, it has been recognized an oncogene diverse range...
Cancer stem cells (CSCs) are considered to be tumor‑initiating cells, responsible for tumor invasive growth and dissemination distant organ sites. Typically, radiation treatment chemotherapy should target CSCs. However, current research investigating CSCs is impeded by the difficulty of isolating pure maintaining them in vitro. In present study, synergistic inhibition glycogen synthase kinase 3 mitogen‑activated protein using small molecules, CHIR99021 PD184352, efficiently generated from...
Abstract Background and Aim Intratumor hypoxia is a hallmark of hepatocellular carcinoma (HCC) associated with an aggressive tumor phenotype. Although it has been shown that AQP9 plays important role in HCC, the relevance between still unknown. Methods We established vitro normoxic or hypoxic models to investigate regulation hypoxia‐inducible factor 1α (HIF‐1α) hypoxia‐enhanced invasion hepatoma cells. Molecular expression was detected using western blot quantitative polymerase chain...
The accuracy and enrichment rate of targeted drugs largely determine the clinical diagnosis treatment effect. Therefore, should be improved. We designed a visual system based on hierarchical targeting. It consists multifunctional magnetic nanoparticles bio material. Bio-magnet mediated primary targeting can effectively improve drug in target tissue. SNF peptide/epithelial cell adhesion molecule antibody liver cancer stem cells (LCSCs) (secondary target) its outcomes. Low intensity focused...
This single center, randomized, and controlled study aimed to compare the effectiveness safety of polyethylene glycol electrolyte lavage (PEG-EL) solution colonic hydrotherapy (CHT) for bowel preparation before colonoscopy. A total 196 eligible outpatients scheduled diagnostic colonoscopy were randomly assigned PEG-EL (n = 102) or CHT 94) groups. Primary outcome measures included cleanliness adverse effects. Secondary patient satisfaction preference, colonoscopic findings, ileocecal arrival...
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