A5004075226- Nanoparticles: synthesis and applications
- Nanoparticle-Based Drug Delivery
- Graphene and Nanomaterials Applications
- Effects and risks of endocrine disrupting chemicals
- Genetically Modified Organisms Research
- Heavy Metal Exposure and Toxicity
- Insect Resistance and Genetics
- Air Quality and Health Impacts
- Birth, Development, and Health
- Carcinogens and Genotoxicity Assessment
- Pesticide and Herbicide Environmental Studies
- Reproductive Biology and Fertility
- Nanoplatforms for cancer theranostics
- Microplastics and Plastic Pollution
- Agricultural safety and regulations
- Estrogen and related hormone effects
- Environmental Toxicology and Ecotoxicology
- Global Healthcare and Medical Tourism
- Visual Culture and Art Theory
- Growth Hormone and Insulin-like Growth Factors
- COVID-19 Impact on Reproduction
- Advanced Nanomaterials in Catalysis
- Fish biology, ecology, and behavior
- Education, Psychology, and Social Research
- Energy and Environment Impacts
Slovak Medical University
2015-2024
Faculty of Public Health
2017-2023
Slovak Academy of Sciences
2013
Tampere University
2001
At present, nanoparticles are beginning to influence our lives in many ways and understanding the environmental health safety aspect of nanomaterials has become a crucial issue. The aim work was assess compare acute toxicity 31 different fish mature individuals Danio rerio with that early life stages on using evaluation 48- 96- hour LC50 values. A further evaluate teratogenicity tested eggs. were: 8 pure metals, 10 metal oxides, 5 other compounds their mixtures, 2 silicon compounds, 3...
Copper oxide nanoparticles (CuO NPs) are increasingly used in various industry sectors. Moreover, medical application of CuO NPs as antimicrobials also contributes to human exposure. Their toxicity, including toxicity the immune system and blood, raises concerns, while information on their immunotoxicity is still very limited. The aim our work was evaluate effects (number concentration 1.40×106 particles/cm3, geometric mean diameter 20.4 nm) immune/inflammatory response antioxidant defense...
The GMO Risk Assessment and Communication of Evidence (GRACE; www.grace-fp7.eu ) project is funded by the European Commission within 7th Framework Programme. A key objective GRACE to conduct 90-day animal feeding trials, studies with an extended time frame as well analytical, in vitro silico on genetically modified (GM) maize order comparatively evaluate their use GM plant risk assessment. In present study, results two trials different MON810 varieties, near-isogenic non-GM varieties four...
In 2012, a controversial study on the long-term toxicity of Roundup herbicide and glyphosate-tolerant genetically modified (GM) maize NK603 was published. The EC-funded G-TwYST research consortium tested potential subchronic chronic as well carcinogenicity glyphosate-resistant by performing two 90-day feeding trials, one with GM inclusion rates 11 33% up to 50%, 2-year trial in male female Wistar Han RCC rats taking into account OECD Guidelines for testing chemicals EFSA recommendations...
Despite the obvious advantages of gold nanoparticles for biomedical applications, controversial and incomplete toxicological data hamper their widespread use. Here, we present results from an in vivo toxicity study using coated with polyethylene glycol (PEG-AuNPs). The pharmacokinetics biodistribution PEG-AuNPs were examined rat’s liver, lung, spleen, kidney after a single i.v. injection (0.7 mg/kg) at different time intervals. had relatively long blood circulation accumulated primarily...
Titanium dioxide nanoparticles (TiO2 NPs) are used in a wide range of applications. Although inhalation NPs is one the most important toxicologically relevant routes, experimental studies on potential harmful effects TiO2 using whole-body chamber model rare. In this study, profile lymphocyte markers, functional immunoassays, and antioxidant defense markers were analyzed to evaluate adverse seven-week exposure two different concentrations (0.00167 0.1308 mg TiO2/m3) mice. A dose-dependent...
Nickel oxide in the form of nanoparticles (NiO NPs) is extensively used different industrial branches. In a test on adult zebrafish, acute toxicity NiO NPs was shown to be low, however longlasting contact with this compound can lead its accumulation tissues and increased toxicity. work we determined 30-day using static for zebrafish Danio rerio. We found LC50 value 45.0 mg/L, LC100 (minimum concentration causing 100% mortality) 100.0 LC0 (maximum no 6.25 mg/L individuals zebrafish....
The GRACE (GMO Risk Assessment and Communication of Evidence; www.grace-fp7.eu ) project was funded by the European Commission within 7th Framework Programme. A key objective to conduct 90-day animal feeding trials, studies with an extended time frame as well analytical, in vitro silico on genetically modified (GM) maize order comparatively evaluate their use GM plant risk assessment. In present study, results a 1-year trial MON810 variety, its near-isogenic non-GM comparator additional...
This study aims to investigate the in vitro effects of nanoparticles (NPs) produced during selective laser melting (SLM) 316 L stainless steel metal powder on immune response a human blood model. Experimental data did not reveal effect viability NPs for tested doses. Functional assays showed significant immunosuppressive NPs. There was moderate stimulation (117%) monocyte phagocytic activity without changes and respiratory burst granulocytes. A dose-dependent increase levels pro-inflammatory...
Objectives: The purpose of this study was to evaluate the effects neonatal exposure herbicide acetochlor (ACT) on pubertal development and reproductive functions in female Wistar rats investigate capability ACT interfere with estradiol binding rat uterine estrogen receptors (ERs) ex vivo.Methods: Acetochlor (7.68 15.36 mg/kg/day) administered by subcutaneous injection from postnatal day (PND) 4–7, vaginal opening, estrous cyclicity were evaluated PND 8-159. A second group adult...
ABSTRACT In vitro immunotoxicity of hydrophobic sodium fluoride‐based nanocrystals (NCs) doped with lanthanide ions was examined in this study. Although there is already a significant amount optical and structural data on NaYF 4 NCs, safety assessment are missing. Therefore, peripheral whole blood from human volunteers used to evaluate the effect 25 30 nm NCs dissolved cyclohexane (CH) lymphocytes, 10 phagocytes. concentration range 0.12–75 µg cm −2 (0.17–106 ml −1 ), both 30nm did not...
The genetically modified maize event MON810 expresses a Bacillus thuringiensis-derived gene, which encodes the insecticidal protein Cry1Ab to control some lepidopteran insect pests such as European corn borer. It has been claimed that immune system may be affected following oral/intragastric administration of in various different animal species. In frame EU-funded project GRACE, two 90-day feeding trials, so-called studies D and E, were performed analyze humoral cellular responses male...
Conventional toxicological methods and integrated transcriptomic analysis were used to comprehensively assess the potential health hazard of residual metal nanoparticles accumulated in body due poor solubility.
Our goal was to evaluate the potential health risk of polymeric NP, poly(ethylene glycol)-block-poly(lactic acid) (PEG-b-PLA), from view redox imbalance organism in two different life stages. Female Wistar rats were neonatally administered intraperitoneally with PEG-b-PLA NPs [20 mg/kg b.w. (PEG20) or 40 (PEG40) b.w.] postnatal day 4 (PND4) PND7. We measured antioxidant capacity (TEAC), level protein carbonyls and lipoperoxides plasma, activities catalase, glutathione peroxidase (GPx),...
It is well documented that pesticides used in agricultural processes may have detrimental effects upon human health. Moreover, many of these compounds been indicated as potential endocrine and reproductive disruptors. In the present study, ability herbicide acetochlor to affect a growth estrogen-sensitive MCF-7 mammary epithelial carcinoma cells was studied using E-screen test. Acetochlor alone did not proliferation cells. Significant inhibition estradiol-induced (10-14-10-8 M) cell by...