A5027020408- Diabetes and associated disorders
- 3D Printing in Biomedical Research
- Graphene and Nanomaterials Applications
- Cardiac Fibrosis and Remodeling
- Transgenic Plants and Applications
- Pancreatic function and diabetes
- Nerve injury and regeneration
- Cardiac Valve Diseases and Treatments
- Bone Tissue Engineering Materials
- Antimicrobial agents and applications
- Hydrogels: synthesis, properties, applications
- Protein purification and stability
- Inhalation and Respiratory Drug Delivery
- Pulmonary Hypertension Research and Treatments
- Advanced Drug Delivery Systems
- Proteoglycans and glycosaminoglycans research
- Advancements in Transdermal Drug Delivery
- Bacterial biofilms and quorum sensing
- Monoclonal and Polyclonal Antibodies Research
- ATP Synthase and ATPases Research
- Dermatology and Skin Diseases
- Escherichia coli research studies
- Corneal Surgery and Treatments
- Mesenchymal stem cell research
- Connective tissue disorders research
University of California, San Francisco
2020-2025
Indian Institute of Technology Bombay
2015
Abstract Tumors exhibit an increased ability to obtain and metabolize nutrients. Here, we implant engineered adipocytes that outcompete tumors for nutrients show they can substantially reduce cancer progression, a technology termed adipose manipulation transplantation (AMT). Adipocytes use amounts of glucose fatty acids by upregulating UCP1 were placed alongside cells or xenografts, leading significant suppression. Transplanting modulated organoids in pancreatic breast genetic mouse models...
Bacterial biofilm infections, particularly those of Pseudomonas aeruginosa (PA), have high rates antimicrobial tolerance and are commonly found in chronic wound cystic fibrosis lung infections. Combination therapeutics that act synergistically can overcome tolerance; however, the delivery multiple at relevant dosages remains a challenge. We therefore developed nanoscale drug carrier for codelivery by combining approaches from polyelectrolyte nanocomplex (NC) formation layer-by-layer...
Introduction: Currently, there are no non-surgical FDA-approved biological approaches to accelerate fracture repair. Injectable therapies designed stimulate bone healing represent an exciting alternative surgically implanted biologics, however, the translation of effective osteoinductive remains challenging due need for safe and drug delivery. Hydrogel-based microparticle platforms may be a clinically relevant solution create controlled localized delivery treat fractures. Here, we describe...
Abstract Heart failure (HF) remains a global public health burden and often results following myocardial infarction (MI). Following injury, cardiac fibrosis forms in the myocardium which greatly hinders cellular function, survival, recruitment, thus severely limits tissue regeneration. Here, we leverage biophysical microstructural cues made of hyaluronic acid (HA) loaded with anti-fibrotic proteoglycan decorin to more robustly attenuate after acute injury. Microrods showed incorporation...
Abstract Beta cell replacement therapy (BCRT) for patients with type 1 diabetes (T1D) improves blood glucose regulation by replenishing the endogenous beta cells destroyed autoimmune attack. Several limitations, including immune isolation, prevent this from reaching its full potential. Cell encapsulation devices used BCRT provide a protective physical barrier insulin‐producing cells, thereby protecting transplanted However, poor device engraftment posttransplantation leads to nutrient...
Sustained delivery of protein therapeutics remains a largely unsolved problem across anatomic locations. Miniaturized devices that can provide sustained formulations have the potential to address this challenge via minimally invasive administration. In particular, methodologies optimize formulation independent device manufacture greatest platform suitable for wide applications. The techniques developed here demonstrate fabrication tubular release therapeutics. Utilizing dip-casting process,...
Chemotherapy Induced Nausea and Vomiting (CINV) is a serious health concern in the treatment of cancer patients. Conventional routes for administering anti-emetics (i.e. oral parenteral) have several drawbacks such as painful injections, poor patient compliance, dependence on skilled personnel, non-affordability to majority population (parenteral), lack programmability suboptimal bioavailability (oral). Hence, we developed trans-epidermal antiemetic drug delivery patch using out-of-plane...
Abstract Currently, there are no biological approaches to accelerate bone fracture repair. Osteobiologics that promote endochondral ossification an exciting alternative surgically implanted grafts, however, the translation of osteobiologics remains elusive because need for localized and sustained delivery is both safe effective. In this regard, injectable system composed hydrogel-based microparticles designed release in a controlled manner ideal context Here, we describe poly (ethylene...
Abstract New approaches are needed to treat bacterial biofilm infections, particularly those of Pseudomonas aeruginosa (PA), which have high rates antimicrobial resistance and commonly found in chronic wound cystic fibrosis lung infections. Combination therapeutics that act synergistically can overcome resistance; however, the delivery multiple at relevant dosages remains a challenge. We therefore developed new nanoscale drug carrier for co-delivery by combining from polyelectrolyte...
Abstract Heart failure (HF) is a global public health burden and associated with significant morbidity mortality. HF can result as complication following myocardial infarction (MI), cardiac fibrosis forming in the myocardium response to injury. The dense, avascular scar tissue that develops after injury MI creates an inhospitable microenvironment hinders cellular function, survival, recruitment, thus severely limiting regeneration. We have previously demonstrated ability of hyaluronic acid...
Pulmonary veno-occlusive disease (PVOD) is a rare form of pulmonary hypertension arising from EIF2AK4 gene mutations or mitomycin C (MMC) administration. The lack effective PVOD therapies compounded by limited understanding the mechanisms driving vascular remodeling in PVOD. We show that administration MMC rats mediates activation protein kinase R (PKR) and integrated stress response (ISR), which lead to release endothelial adhesion molecule VE-Cadherin complex with Rad51 circulation,...
Abstract Thermolabile nature of commercially available vaccines necessitates their storage, transportation and dissemination under refrigerated condition. Maintenance continuous cold chain at every step increases the final cost vaccines. Any breach in chain, even for a short duration results need to discard vaccine. As result, there is pressing development thermostable In this proof concept study, we showed that E. coli curli-GFP fusion protein remains stable freeze-dried yeast powder more...