A5046388049- Bone Tissue Engineering Materials
- Orthopaedic implants and arthroplasty
- Graphene and Nanomaterials Applications
- Insect behavior and control techniques
- Immune responses and vaccinations
- Hip disorders and treatments
- Musculoskeletal synovial abnormalities and treatments
- Insect-Plant Interactions and Control
- Shoulder and Clavicle Injuries
- Knee injuries and reconstruction techniques
- Nerve injury and regeneration
- Plant and animal studies
- 3D Printing in Biomedical Research
- Connective tissue disorders research
- Tendon Structure and Treatment
- Shoulder Injury and Treatment
- Bone fractures and treatments
- Telomeres, Telomerase, and Senescence
Steadman Philippon Research Institute
2021-2024
Introduction: Currently, there are no non-surgical FDA-approved biological approaches to accelerate fracture repair. Injectable therapies designed stimulate bone healing represent an exciting alternative surgically implanted biologics, however, the translation of effective osteoinductive remains challenging due need for safe and drug delivery. Hydrogel-based microparticle platforms may be a clinically relevant solution create controlled localized delivery treat fractures. Here, we describe...
Objectives: To use a novel, validated bioassay to monitor serum concentrations of breakdown product collagen X in prospective longitudinal study patients sustaining isolated tibial plateau fractures. Collagen is the hallmark extracellular matrix protein present during conversion soft, cartilaginous callus bone endochondral repair. Previous preclinical and clinical studies demonstrated distinct peak biomarker (CXM) levels after long Setting: Level 1 academic trauma facility....
Background: While an association between femoroacetabular impingement (FAI) and osteoarthritis (OA) has been reported, the mechanistic differences transition 2 conditions is not fully understood. In FAI, cartilage lesions at femoral head-neck junction can sometimes be visualized during hip arthroscopy. Purpose/Hypothesis: The purpose of this study was to describe a unique dimpled pattern superficial fissured on site in patients with FAI syndrome (FAIS) evaluate clinical, histological,...
Abstract Currently, there are no biological approaches to accelerate bone fracture repair. Osteobiologics that promote endochondral ossification an exciting alternative surgically implanted grafts, however, the translation of osteobiologics remains elusive because need for localized and sustained delivery is both safe effective. In this regard, injectable system composed hydrogel-based microparticles designed release in a controlled manner ideal context Here, we describe poly (ethylene...
Objectives: Although age-related chronic conditions are major drivers of morbidity and healthcare costs, most have proven difficult to prevent or treat. Fundamental aging processes may be root cause contributors all these disorders, among mechanisms is cellular senescence. These cells can release pro-inflammatory cytokines/chemokines other factors, otherwise known as the senescence-associated secretory phenotype (SASP). Specifically, senescent CD3+ T-Cells been linked such frailty,...
Rotator cuff tears are a common soft tissue injury that can significantly decrease function of the shoulder and cause severe pain. Despite progress in surgical technique, rotator repairs (RCRs) do not always heal efficiently. Many failures occur at bone-tendon interface as result poor healing capacity tendon failure to regenerate native histological anatomy enthesis. While allografts commercially available, clinical use is limited they stimulate regeneration associated with structural up 40%...