A5065669814- Shoulder Injury and Treatment
- Shoulder and Clavicle Injuries
- Hip disorders and treatments
- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Nerve Injury and Rehabilitation
- Knee injuries and reconstruction techniques
- Orthopedic Surgery and Rehabilitation
- Sports injuries and prevention
- Trauma Management and Diagnosis
- Lower Extremity Biomechanics and Pathologies
- Hip and Femur Fractures
- Osteoarthritis Treatment and Mechanisms
- Musculoskeletal synovial abnormalities and treatments
- Periodontal Regeneration and Treatments
- Pelvic and Acetabular Injuries
- Cardiac Valve Diseases and Treatments
- Elbow and Forearm Trauma Treatment
- Cerebral Palsy and Movement Disorders
- Tendon Structure and Treatment
- Mesenchymal stem cell research
- Inflammatory mediators and NSAID effects
- Bone Tissue Engineering Materials
- Bone fractures and treatments
- Blood transfusion and management
Steadman Philippon Research Institute
2020-2025
Steadman Clinic
2020-2025
University of Pittsburgh Medical Center
2021-2023
Spencer Foundation
2023
Rothman Orthopaedics
2022
American Orthopaedic Society for Sports Medicine
2022
Arthrex (United States)
2022
Rex Medical (United States)
2022
Arthroscopy Association of North America
2022
Hospital for Special Surgery
2015-2022
Segmental bone defects that are caused by trauma, infection, tumor resection, or osteoporotic fractures present significant surgical treatment challenges. Host autograft is considered the gold standard for restoring function but comes with cost of harvest site comorbidity. Allograft a secondary option has its own limitations in incorporation host as well cost. Therefore, developing new tissue engineering strategies to treat critically needed. In past three decades, use stem cells delivered...
Background: Although critical bone loss for anterior instability is well defined, a clinically significant threshold of posterior has not been elucidated. Hypothesis: Patients with failed arthroscopic shoulder capsulolabral repair will have increased glenoid defined threshold. Study Design: Case control study; Level evidence, 3. Methods: Athletes older than 18 years unidirectional treated were evaluated at 2-year minimum follow-up. Failure was as revision surgery, American Shoulder and Elbow...
Duchenne muscular dystrophy (DMD) is a severe genetic muscle disease occurring due to mutations of the dystrophin gene. There no cure for DMD. Using dystrophin−/−utrophin−/− (DKO-Hom) mouse model, we investigated PGE2/EP2 pathway in pathogenesis dystrophic and its potential as therapeutic target. We found that Ep2, Ep4, Cox-2, 15-Pgdh mRNA, PGE2 were significantly increased DKO-Hom mice compared wild-type (WT) mice. The EP2 EP4 receptors mainly expressed CD68+ macrophages tissues both...
Hip dysplasia is prevalent in nonambulatory children with cerebral palsy, and may contribute to a decreased quality of life (Lonstein J Pediatr Orthop 6:521-526, 1). Reconstructive procedures such as femoral varus derotation osteotomy or without pelvic are commonly employed the goal achieving maintaining well reduced hips.The goals this study both characterize complications reconstructive identify risk factors that these complications.A retrospective analysis was conducted among 61 (93 hips)...
Background: Labral augmentation and labral reconstruction have emerged as essential procedures for restoring the anatomic functional characteristics of hip joint in patients with a deficient labrum or irreparable tear. Hypothesis/Purpose: The purpose this study was to compare allograft autograft augmentation. We hypothesized that autografts would entail fewer revision arthroscopic procedures. Study Design: Cohort study; Level evidence, 3. Methods: Patients were identified who underwent using...
Nonunion following bone fracture and segmental defects are challenging clinical conditions. To combat this dilemma, development of new tissue engineering therapies using biocompatible materials to deliver growth factors is desirable. This aim study use a heparin/polycation coacervate sustained-release platform compare 5 morphogenetic proteins (BMPs) for promoting defect healing in critical sized calvarial model. The vitro 3D osteogenic pellet cultures assays demonstrated that BMPs 2, 4, 6, 7...
Segmental bone defects caused by trauma, infection, tumor resection or osteoporotic fractures present significant surgical treatment challenges. Host autograft is considered the gold standard to restore function but comes with cost of harvest site comorbidity. Allograft a secondary option has its own limitations in incorporation host as well cost. Therefore, developing new tissue engineering strategies treat critically needed. In past three decades, use stem cells delivered different...
Background: A previous publication demonstrated that the oral intake of losartan promoted microfracture-mediated hyaline-like cartilage repair in osteochondral defects a rabbit knee model. However, an intra-articular (IA) injection may have direct beneficial effects on and has not been studied. Purpose: To determine dosage IA normal homeostasis. Study Design: Controlled laboratory study. Methods: Rabbits were divided into 5 groups (n = 6 each): microfracture group (MFX group) 4 different...
Knowledge of anatomy and physiology the meniscus is essential for appropriate treatment. The unique medial lateral blood supply play an important role in decision making. Controversy exists regarding optimal treatment meniscal tears including débridement, repair, root transplantation. tear location morphology thus plays determination Repair generally advised types with healing potential to preserve function joint health.
Labral augmentation has emerged as an essential procedure to address a deficient or irreparable labrum while preserving native labral tissue and restoring the hip suction seal mechanism.To evaluate midterm outcomes of arthroscopic for insufficiency after previous arthroscopy.Case series; Level evidence, 4.Patients were identified from prospectively collected database who underwent between January 2011 2017 with minimum 3-year follow-up. Pre- postoperative patient-reported outcome scores...