A5021459310- Advanced MRI Techniques and Applications
- Cardiomyopathy and Myosin Studies
- Muscle Physiology and Disorders
- Ultrasound and Hyperthermia Applications
- Cardiovascular Function and Risk Factors
- MRI in cancer diagnosis
- Cardiac Imaging and Diagnostics
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Effects of Exercise
- Photoacoustic and Ultrasonic Imaging
- Genetic Neurodegenerative Diseases
- Hemoglobinopathies and Related Disorders
- Chronic Kidney Disease and Diabetes
- Advanced Neuroimaging Techniques and Applications
- Infrared Thermography in Medicine
- Ultrasonics and Acoustic Wave Propagation
- Ultrasound Imaging and Elastography
- Muscle activation and electromyography studies
- Mitochondrial Function and Pathology
- Cardiac Fibrosis and Remodeling
- Iron Metabolism and Disorders
- Metabolism and Genetic Disorders
- Elasticity and Material Modeling
- Cardiac pacing and defibrillation studies
- Cardiovascular Health and Disease Prevention
The University of Texas Southwestern Medical Center
2021-2025
Advanced Imaging Research (United States)
2021-2025
Southwestern Medical Center
2024
University of Colombo
2016-2021
General Sir John Kotelawala Defence University
2019
National Hospital of Sri Lanka
2017
Cincinnati Children's Hospital Medical Center
2007-2016
Children's Hospital & Medical Center
2014
University of Cincinnati
1998-2010
Stanford University
2001-2005
Relaxation time measurements at 3.0 T are reported for both gray and white matter in normal human brain. Measurements were made using a Bruker Biospec magnetic resonance imaging (MRI) scanner adults with no clinical evidence of neurological disease. Nineteen subjects, 8 female 11 male, studied T1 T2 measurements, 7 males T*2. saturation recovery method T1, multiple spin-echo experiment T2, fast low-angle shot (FLASH) sequence 14 different echo times Results the summarized as follows. Average...
Following myocardial infarction, nonischemic myocyte death results in infarct expansion, loss, and ventricular dysfunction. Here, we demonstrate that a specific proapoptotic gene, Bnip3, minimizes remodeling the mouse, despite having no effect on early or late size. We evaluated effects of ablating Bnip3 cardiomyocyte death, size, after surgical ischemia/reperfusion (IR) injury mice. Immediately following IR, significant differences were observed between Bnip3–/– WT However, at 2 days...
Barth syndrome is an X-linked genetic disorder caused by mutations in the tafazzin (taz) gene and characterized dilated cardiomyopathy, exercise intolerance, chronic fatigue, delayed growth, neutropenia. Tafazzin a mitochondrial transacylase required for cardiolipin remodeling. Although function has been studied non-mammalian model organisms, mammalian loss of approaches have not used. We examined consequences knockdown on sarcomeric mitochondria cardiac mice. resulted dramatic decrease...
Background— Pathological cardiac hypertrophy inevitably remodels, leading to functional decompensation. Although modulation of apoptosis-regulating genes occurs in hypertrophy, a causal role for programmed cardiomyocyte death left ventricular (LV) remodeling has not been established. Methods and Results— We targeted the gene proapoptotic Nix, which is transcriptionally upregulated pressure overload Gq-dependent hypertrophies, mouse germ line or specifically cardiomyocytes (knockout [KO])...
Significance Sickle cell anemia (SCA) is a common monogenic disorder associated with significant morbidity and mortality high incidence of unexplained sudden death in young adults. With the prevention infections, there an increasing appreciation for cardiopulmonary complications cardiac phenotype that cannot be solely attributed to chronic anemia. We used mouse models SCA iron-deficient show distinct functional, pathological, ultrastructural, molecular features causing unique restrictive...
Tobacco mosaic virus conjugated to TEMPO creates a new magnetic resonance imaging agent that detects superoxide produced in inflamed liver conditions.
Dilated cardiomyopathy (DCM) due to genetic disorders results in decreased myocardial contractility, leading high morbidity and mortality rates. There are several therapeutic challenges treating DCM, including poor understanding of the underlying mechanism impaired contractility difficulty developing targeted therapies reverse mutation-specific pathologies. In this report, we focused on K210del, a DCM-causing mutation, 3-nucleotide deletion sarcomeric troponin T (TnnT), resulting loss...
Abstract Cryosurgery has been shown to be an effective therapy for prostate cancer. Temperature monitoring throughout the cryosurgical iceball could dramatically improve efficacy, since end temperatures of at least –40°C are required. The results this study indicate that MR thermometry based on tissue R potential provide information. Frozen appears as a complete signal void conventional MRI. Ultrashort echo times (TEs), achievable with half pulse excitation and short spiral readout, allow...
Abstract Purpose To investigate the peak temperature and thermal dose (T 43 ) as tissue damage indicators for therapy. Materials Methods The proton resonant frequency (PRF) shift coefficient was calibrated on six in vivo rabbit brains during interstitial laser ablation. T were correlated with lesion boundary observed T2‐weighted spin‐echo (SE) MRI at 4 hours post‐heating seven lesions using direct MR measurement analysis based a binary discriminate model. Results 48.3 ± 1.7°C 191 219...
A method was developed for quantitating the temperature within frozen tissue with magnetic resonance (MR) parameter R2*. The pulse sequence uses half-pulse excitation and a short spiral readout to achieve echo times as 0.2 msec. Fiber-optic sensors were inserted into bovine liver tissue. at one end while being held warm other end. Once steady state reached, R2* measured. linear dependence of on demonstrated. is independent freeze number orientation gradient respect main field. Feasibility in...
Although previous studies have helped define the natural history of Duchenne muscular dystrophy (DMD)-associated cardiomyopathy, myocardial pathobiology associated with functional impairment in DMD is not yet known.The objective this study was to assess distribution transverse relaxation time (T2) left ventricle (LV) patients, and determine association T2 heterogeneity severity cardiac dysfunction. patients (n = 26) normal control subjects 13) were studied by cardiovascular magnetic...
Cardiac dysfunction in boys with Duchenne muscular dystrophy (DMD) is a leading cause of death. resynchronization therapy (CRT) has been shown to dramatically decrease mortality eligible adult population congestive heart failure. We hypothesized that mechanical dyssynchrony present DMD patients and cardiovascular magnetic resonance (CMR) may predict CRT efficacy.
The robustness of a complex network measures its ability to withstand random or targeted attacks. Most operate under the assumption that nodes in are homogeneous and abstract. However, most real-world networks consist heterogeneous nature. In this work, we propose measure called fitness-incorporated average efficiency, attempts capture heterogeneity using ‘fitness’ measuring network. Further, adopt same compare with varying topologies, such as scale-free topology Erdős–Rényi topology. We...