A5006348854- Cardiovascular Function and Risk Factors
- Elasticity and Material Modeling
- Cardiac Structural Anomalies and Repair
- Composite Material Mechanics
- Cardiac Valve Diseases and Treatments
- Cardiac Imaging and Diagnostics
- Pulmonary Hypertension Research and Treatments
- Nonlocal and gradient elasticity in micro/nano structures
- 3D Printing in Biomedical Research
- Cardiomyopathy and Myosin Studies
- Advanced MRI Techniques and Applications
- Tissue Engineering and Regenerative Medicine
- Numerical methods in engineering
- Congenital Heart Disease Studies
- Advanced Mathematical Modeling in Engineering
- Cardiovascular Disease and Adiposity
- Composite Structure Analysis and Optimization
- Electrospun Nanofibers in Biomedical Applications
- Cardiac electrophysiology and arrhythmias
- Seismic Waves and Analysis
- Cardiovascular Health and Disease Prevention
- Acoustic Wave Phenomena Research
- Rheology and Fluid Dynamics Studies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Force Microscopy Techniques and Applications
Houston Methodist
2013-2025
Texas A&M University
2020-2025
Walker (United States)
2021-2024
Mitchell Institute
2022-2024
University of Cincinnati Medical Center
2024
Cincinnati Children's Hospital Medical Center
2021
University of Cincinnati
2021
The University of Texas at Austin
2016-2020
University of Pennsylvania
2009-2017
University of Pittsburgh
2017
Right ventricular (RV) diastolic function has been associated with outcomes for patients pulmonary hypertension; however, the relationship between biomechanics and hemodynamics in right ventricle not studied.Rat models of RV pressure overload were obtained via artery banding (PAB; control, n=7; PAB, n=5). At 3 weeks after banding, measured using a conductance catheter. Biaxial mechanical properties free wall myocardium to extrapolate longitudinal circumferential elastic modulus low high...
Background: Global indices of right ventricle (RV) function provide limited insights into mechanisms underlying RV remodeling in pulmonary hypertension (PH). While myocardial architectural has been observed PH, its effect on adaptation is poorly understood. Methods: Hemodynamic assessments were performed 2 rodent models PH. free wall myoarchitecture was quantified using generalized Q-space imaging and tractography analyses. Computational developed to predict strains. Data from animal studies...
Abstract Vascular cell overgrowth and lumen size reduction in pulmonary vein stenosis (PVS) can result elevated PV pressure, hypertension, cardiac failure, death. Administration of chemotherapies such as rapamycin have shown promise by inhibiting the vascular proliferation; yet clinical success is limited due to complications restenosis off‐target effects. The lack vitro models recapitulate complex pathophysiology PVS has hindered identification disease mechanisms therapies. This study...
Abstract In-vivo estimation of mechanical properties the myocardium is essential for patient-specific diagnosis and prognosis cardiac disease involving myocardial remodeling, including infarction heart failure with preserved ejection fraction. Current approaches use time-consuming finite-element (FE) inverse methods that involve reconstructing meshing geometry, imposing measured loading, conducting computationally expensive iterative FE simulations. In this paper, we propose a machine...
The heterogeneity in myofiber helicity across the cardiac wall causes twisting (torsion) left ventricle (LV) during contraction, which is a significant contributor to its pumping function. Although important progress has been made identifying and studying quantitative "global" metric for torsion, four-dimensional (4D) torsion characteristics LV remain underexplored. We propose an imaging-based framework that uses myocardial motion obtained from cine magnetic resonance (CMR) scans of...
ABSTRACT Lung biomechanics aims to understand the structure-function relationship in lung under normal and pathological conditions. Pulmonary surfactant has a key structural role function with significant contribution mechanical response of lungs during respiration. dynamically regulates surface tension at air-liquid interface decrease stiffness respiration prevent alveolar collapse lower volumes. Many injuries involve alterations surfactants function. We developed novel biophysical model...
Pulmonary hypertension (PH) results in increased right ventricular (RV) afterload, leading to RV dysfunction and failure. The mechanisms underlying maladaptive remodeling are poorly understood. In this study, we investigated the multiscale mechanistic nature of free-wall (RVFW) biomechanical its correlations with function adaptations. Mild severe models PH, consisting a hypoxia model Sprague-Dawley rats (n=6 each, control PH) Sugen-hypoxia Fischer PH), were used. Organ-level function,...
In this paper, a comprehensive model is presented to investigate the influence of surface elasticity and residual tension on natural frequency flexural vibrations microbeams in presence rotary inertia shear deformation effects. An explicit solution derived for oscillations microscaled Timoshenko beams considering The analytical results are illustrated with numerical examples which two types configured based Euler–Bernoulli beam theory tension. frequencies vibration calculated selected length...
Pulmonary arterial hypertension (PAH) imposes substantial pressure overload on the right ventricular free wall (RVFW), leading to myofiber hypertrophy and remodeling of its collagen fiber architecture. The transmural nature these adaptations their effects macroscopic mechanical behavior RVFW remain largely unexplored. In present work, we extended our constitutive model for myocardium investigate structural post-PAH. Recent murine experimental studies provided us with comprehensive...
Pulmonary arterial hypertension (PAH) exerts substantial pressure overload on the right ventricle (RV), inducing RV remodeling and myocardial tissue adaptation often leading to heart failure. The associated free wall (RVFW) involves hypertrophy, augmented intrinsic contractility, collagen fibrosis, structural in an attempt cope with overload. If RVFW cannot maintain stroke volume (SV), dilation will prevail as exit mechanism, which usually decompensates function, Our knowledge of factors...
Abstract The heart is the first organ to develop in human embryo through a series of complex chronological processes, many which critically rely on interplay between cells and dynamic microenvironment. Tight spatiotemporal regulation these interactions key development diseases. Due suboptimal experimental models, however, little known about role microenvironmental cues development. This study investigates use 3D bioprinting perfusion bioreactor technologies create bioartificial constructs...