A5055701402- Tissue Engineering and Regenerative Medicine
- Advancements in Transdermal Drug Delivery
- Cardiovascular Function and Risk Factors
- Systemic Lupus Erythematosus Research
- Protein purification and stability
- Advanced Drug Delivery Systems
- Cardiac Arrhythmias and Treatments
- Pluripotent Stem Cells Research
- Cardiac Structural Anomalies and Repair
- Cardiac pacing and defibrillation studies
- Pericarditis and Cardiac Tamponade
- Cardiac Imaging and Diagnostics
- Microfluidic and Bio-sensing Technologies
- Congenital heart defects research
- Cardiac electrophysiology and arrhythmias
- Systemic Sclerosis and Related Diseases
- Blood Coagulation and Thrombosis Mechanisms
- Cardiovascular Issues in Pregnancy
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver physiology and pathology
- Microfluidic and Capillary Electrophoresis Applications
- Cardiac tumors and thrombi
- Platelet Disorders and Treatments
- Cardiovascular Effects of Exercise
- Atrial Fibrillation Management and Outcomes
University of Pittsburgh
2017-2024
University of Pittsburgh Medical Center
2022-2023
Matrix Research (United States)
2019
St. Luke's Hospital
2019
Mayo Clinic
2019
Mayo Clinic in Arizona
2019
IIT@MIT
2012
Massachusetts Institute of Technology
2011
The availability of an autologous transplantable auxiliary liver would dramatically affect the treatment disease. Assembly and function in vivo a bioengineered human derived from induced pluripotent stem cells (iPSCs) has not been previously described. By improving methods for decellularization, recellularization, differentiation different cellular lineages iPSCs organ-like environment, we generated functional engineered mini livers performed transplantation rat model. Whereas previous...
Right ventricular (RV) diastolic function has been associated with outcomes for patients pulmonary hypertension; however, the relationship between biomechanics and hemodynamics in right ventricle not studied.Rat models of RV pressure overload were obtained via artery banding (PAB; control, n=7; PAB, n=5). At 3 weeks after banding, measured using a conductance catheter. Biaxial mechanical properties free wall myocardium to extrapolate longitudinal circumferential elastic modulus low high...
In the stomach, a layer of gastric mucus protects epithelial cells stomach wall against damage by acidic digestive juices in lumen. Despite considerable research, biophysical mechanisms for this acid barrier are not understood. We present an vitro microfluidic tool to characterize barrier, which purified mucin polymers "secreted" zone on chip, mimicking vivo secretion into This device reconstitutes both H(+) concentration gradient and outward flow environment vivo. Our experiments...
Abstract Background Methylergonovine is a vasoconstrictive agent historically used as provocative in the lab for coronary vasospasm; it also first line uterotonic management of postpartum hemorrhage. Case Presentation A 29-year-old female with history smoking and idiopathic thrombocytopenia received intramuscular methylergonovine after delivery twins intrauterine hemorrhage management. Subsequently, she had episodes chest pain high sensitivity Troponin I elevation to 1509 ng/L accompanying...
Background: There is growing interest in understanding microbubble ( MB ) behavior under ultrasound US complex vivo environments, to optimize safety and efficacy for various clinical applications, e.g. , large molecule drug delivery, temporary blood-brain-barrier opening, thrombus disintegration. However, there have been few mechanistic studies due the challenges of visualizing vibrating MBs circulation at high temporal resolutions. Our study elucidates interactions with surrounding...
Case Presentation: A 29-year-old man with a history of hyperthyroidism presented to an outside hospital altered mentation and palpitations in the setting non-adherence thyroid medications. He was found be atrial fibrillation rapid ventricular response. Initial vital signs included heart rate 165 beats/min, respiratory 43 breaths/min, blood pressure 134/115 mmHg, O2 saturation 94% on 2L oxygen. Point care ultrasound showed EF 10% dilated IVC. Labs creatinine 0.7 mg/dL, total bilirubin 3.9 ALT...
Introduction: Pulmonary hypertension (PH) associated with left heart disease can be stratified as isolated post-capillary (IpcPH) or combined pre and postcapillary (CpcPH) on the basis of a normal elevated pulmonary vascular resistance (PVR). While CpcPH carries poor prognosis, mechanistic determinants PVR in this population remain undefined. We hypothesize that discrepant medication usage between hemodynamic extremes IpcPH may underlie phenotypic divergence. Methods: Invasive hemodynamics...