A5089933622- Peroxisome Proliferator-Activated Receptors
- Asthma and respiratory diseases
- Immune Response and Inflammation
- Eicosanoids and Hypertension Pharmacology
- Inflammatory mediators and NSAID effects
- Respiratory Support and Mechanisms
- Inhalation and Respiratory Drug Delivery
- Pulmonary Hypertension Research and Treatments
- Curcumin's Biomedical Applications
- Respiratory and Cough-Related Research
- Nuclear Receptors and Signaling
- Sepsis Diagnosis and Treatment
- Macrophage Migration Inhibitory Factor
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Vaccine Coverage and Hesitancy
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory viral infections research
- Cardiovascular Function and Risk Factors
- NF-κB Signaling Pathways
- Metabolism, Diabetes, and Cancer
- Immune cells in cancer
- SARS-CoV-2 and COVID-19 Research
- Cardiomyopathy and Myosin Studies
- Neonatal Respiratory Health Research
- IL-33, ST2, and ILC Pathways
Oregon Health & Science University
2022-2025
University of Pittsburgh
2013-2024
VA Pittsburgh Healthcare System
2013-2024
The University of Texas at Austin
2023-2024
Oregon Health and Science University Hospital
2022
University of Florida
2021
Matrix Research (United States)
2019
Kettering General Hospital NHS Trust
2013
Emory University
2008-2012
Atlanta VA Medical Center
2012
Transforming growth factor-β (TGF-β) induces epithelial-mesenchymal transition (EMT) of epithelial cells in both normal embryonic development and certain pathological contexts. Here, we show that TGF-β induced-EMT human lung cancer (A549; adenocarcinoma cells) mediates tumor cell migration invasion phenotypes. To gain insights into molecular events during EMT, employed a global stable isotope labeled profiling strategy using iTRAQ reagents, followed by 2DLC−MS/MS, which identified total 51...
Pulmonary fibrosis is characterized by alterations in fibroblast phenotypes resulting excessive extracellular matrix accumulation and anatomic remodeling. Current therapies for this condition are largely ineffective. Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) a member of the nuclear hormone receptor superfamily, activation which produces number biological effects, including metabolic inflammatory responses. The role PPAR-gamma as potential therapeutic target fibrotic lung...
ABSTRACT The roles of CXC chemokine-mediated host responses were examined with an A/J mouse model Legionella pneumophila pneumonia. After intratracheal inoculation 10 6 CFU L. , the bacterial numbers in lungs increased 10-fold by day 2; this increase was accompanied massive accumulation neutrophils. Reverse transcription-PCR data demonstrated up-regulation chemokines, such as keratinocyte-derived chemokine, macrophage inflammatory protein 2 (MIP-2), and lipopolysaccharide-induced chemokine...
Activation of peroxisome proliferator-activated receptor-γ (PPAR-γ) results in inhibition tumor growth various types cancers, but the mechanism(s) by which PPAR-γ induces arrest has not been completely defined. In a recent study, we demonstrated that treatment A549 (human non small cell lung cancer line) tumor-bearing SCID mice with ligands troglitazone (Tro) and pioglitazone significantly inhibits primary growth. this immunohistochemical analysis Tro-treated Pio-treated tumors factor VIII...
Idiopathic pulmonary fibrosis (IPF) is a progressive and typically fatal lung disease for which no effective therapy has been identified. The characterized by excessive collagen deposition, possibly in response to dysregulated wound healing. Mediators normally involved would healing induce proliferation of fibroblasts their differentiation myofibroblasts that actively secrete collagen. Curcumin, polyphenolic compound from turmeric, shown exert variety biological effects. Effects on IPF...
Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal disease, thought to be largely transforming growth factor β (TGFβ) driven, for which there no effective therapy. We assessed the potential benefits in IPF of nitrated fatty acids (NFAs), are unique endogenous agonists peroxisome proliferator-activated receptor γ (PPARγ), nuclear hormone that exhibits wound-healing and antifibrotic properties potentially useful found PPARγ down-regulated patients with IPF. In vitro, knockdown or...
Asthma affects approximately 300 million people worldwide, significantly impacting quality of life and healthcare costs. While current therapies are effective in controlling many patients' symptoms, a large number continue to experience exacerbations or treatment-related adverse effects. Alternative thus urgently needed. Accumulating evidence has shown that the peroxisome proliferator-activated receptor (PPAR) family nuclear hormone receptors, comprising PPARα, PPARβ/δ, PPARγ, is involved...
We evaluated the diagnostic yield of bilateral bronchoalveolar lavage (BAL) in patients with acute respiratory distress syndrome (ARDS) suspected ventilator-associated pneumonia (VAP) and compared BAL results from contralateral sites. Ninety-four ARDS VAP underwent 172 bronchoscopies (344 BALs). was processed for quantitative cultures, total cell count subjected to microscopic analysis differential, presence intracellular organisms (ICO), Gram stain. The threshold a growth ⩾ 104 cfu/ml...
Background Curcumin (diferuloylmethane) shows significant activity across a wide spectrum of conditions, but its usefulness is rather limited because low bioavailability. Use nanoparticle formulations to enhance curcumin bioavailability an emerging area research. Methodology/Principal Findings In the present study, curcumin-loaded apotransferrin nanoparticles (nano-curcumin) prepared by sol-oil chemistry and were characterized electron atomic force microscopy. Confocal studies fluorimetric...
Chronic obstructive pulmonary disease (COPD) is a progressive inflammatory condition and leading cause of death, with no available cure. We assessed the actions in epithelial cells peroxisome proliferator-activated receptor γ (PPARγ), nuclear hormone anti-inflammatory effects, whose role COPD largely unknown. found that PPARγ was down-regulated lung tissue patients, via both reduced expression phosphorylation-mediated inhibition, whereas pro-inflammatory factor-κB (NF-κB) activity increased....
Cigarette smoke, a source of numerous oxidants, produces oxidative stress and exaggerated inflammatory responses that lead to irreversible lung tissue damage. It is the single, most significant risk factor for chronic obstructive pulmonary disease (COPD). Although an intrinsic defense system includes both enzymatic non-enzymatic modulators exists protect tissues against stress, impairment these protective mechanisms has been demonstrated in smokers COPD patients. The antioxidant enzyme GSH...
Transforming growth factor β (TGF-β) contributes to wound healing and, when dysregulated, pathological fibrosis. TGF-β and the anti-fibrotic nuclear hormone receptor peroxisome proliferator-activated γ (PPARγ) repress each other's expression, such PPARγ down-regulation is prominent in fibrosis mediated, via previously unknown SMAD-signaling mechanisms. Here, we show that induces association of SMAD3 with both SMAD4, needed for translocation complex into nucleus, essential context-sensitive...
Abstract Background During the COVID‐19 pandemic, self‐reported vaccination might facilitate rapid evaluations of vaccine effectiveness (VE) when source documentation (e.g., immunization information systems [IIS]) is not readily available. We evaluated concordance status ascertained by self‐report versus and its impact on VE estimates. Methods Hospitalized adults (≥18 years) admitted to 18 U.S. medical centers March–June 2021 were enrolled, including cases SARS‐CoV‐2 negative controls....
Managing sepsis and fluid resuscitation in patients with chronic kidney disease or end-stage renal is challenging for health care providers. Nurses are essential early identification treatment of these patients. Nurse education on assessing perfusion implementing 3-hour bundled can improve mortality rates sepsis. In this scoping review, initial screening identified 1176 articles published from 2015 through 2023 the National Library Medicine database; 29 were included literature summary...