A5056495741- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Uterine Myomas and Treatments
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Endometriosis Research and Treatment
- Enhanced Recovery After Surgery
- Cancer Mechanisms and Therapy
- Epigenetics and DNA Methylation
- Chromatin Remodeling and Cancer
- Anesthesia and Pain Management
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer Immunotherapy and Biomarkers
- Genetic factors in colorectal cancer
- BRCA gene mutations in cancer
- Cancer, Hypoxia, and Metabolism
- Cervical Cancer and HPV Research
- Prenatal Screening and Diagnostics
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Chromosomal and Genetic Variations
- Viral-associated cancers and disorders
- Ferroptosis and cancer prognosis
- Body Contouring and Surgery
- Pain Management and Opioid Use
Memorial Sloan Kettering Cancer Center
2023-2025
Sidney Kimmel Comprehensive Cancer Center
2018-2024
Johns Hopkins University
2017-2024
Johns Hopkins Medicine
2017-2023
Coney Island Hospital
2021-2022
Johns Hopkins Hospital
2018-2020
Matrix Research (United States)
2019
Danish Cancer Society
2018
Cancer Genetics (United States)
2018
NYU Langone Health
2018
Endometrial and ovarian cancers can be detected through the analysis of DNA from Pap test fluids, intrauterine samples, plasma.
Amplification and overexpression of the MYC oncogene in tumor cells, including ovarian cancer correlates with poor responses to chemotherapy. As is not directly targetable, we have analyzed molecular pathways downstream identify potential therapeutic targets. Here report that cells overexpressing glutaminase (GLS), a target key enzyme glutaminolysis, are intrinsically resistant platinum-based chemotherapy enriched intracellular antioxidant glutathione. Deprivation glutamine by...
High-grade serous ovarian carcinoma (HGSOC) typically remains undiagnosed until advanced stages when peritoneal dissemination has already occurred. Here, we sought to identify HGSOC-specific alterations in DNA methylation and assess their potential provide sensitive specific detection of HGSOC at its earliest stages.MethylationEPIC genome-wide analysis was performed on a discovery cohort comprising 23 HGSOC, 37 non-HGSOC malignant, 36 histologically unremarkable gynecologic tissue samples....
Abstract Clinicopathological evidence supports endometrial atypical hyperplasia (AH) or intraepithelial neoplasia as the precursor of uterine endometrioid carcinoma (EC), most common gynecologic malignancy. However, pathogenic progression from AH to EC remains unclear. Here, we employed whole‐exome sequencing identify somatic mutations and copy number changes in micro‐dissected lesions 30 pairs newly diagnosed EC. We found that all but one pair AHs shared same DNA mismatch repair status...
(Abstracted from Sci Transl Med 2018;10:eaap8793) Although the Papanicolaou (Pap) test has dramatically decreased mortality cervical cancer in screened population, generally is unable to detect endometrial or ovarian cancers. These 2 cancers are usually diagnosed at an advanced stage when prognosis poor and treatment does not increase relative survival.
<h3>Objective</h3> Increased glutamine metabolism by cancer cells via upregulation of the drug-targetable enzyme glutaminase may contribute to an immune-suppressive tumor microenvironment. Inhibiting can not only suppress growth, but also enhance tumor-specific immunity. We investigated relationship between expression, immune microenvironment, and clinicopathologic features in endometrial cancer. <h3>Methods</h3> Tissue microarrays constructed from 87 primary specimens were stained...
Background Adjuvant therapy in early-stage endometrial cancer has not shown a clear overall survival benefit, and hence, patient selection remains crucial. Objective To determine whether women with high-intermediate risk, lymphovascular space invasion particularly benefit from adjuvant treatment improving oncologic outcomes. Methods A multi-center retrospective study was conducted stage IA, IB, II who met criteria for risk by Gynecologic Oncology Group (GOG) 99. Patients were stratified the...
Placental site nodule (PSN) is a benign proliferation of chorionic-type intermediate trophoblastic cells that forms tumor-like lesion. Most PSNs are intrauterine, but few have been reported outside the uterus, including in fallopian tubes. PSN related to epithelioid tumor (ETT) both composed cells, while ETT hypercellular and contains with increased nuclear atypia higher Ki-67 index as compared PSN. Occasionally, an stage between observed, such lesion often recognized atypical (aPSN)...
8 Background: We performed microsatellite instability testing and expression immune profiling of endometrioid serous carcinomas to identify immunotherapeutic targets histologic attribute correlates. Methods: Microsatellite RNA-seq 395 immune-related genes were in 37 53 carcinomas. Each gene was ranked against a reference population subsequently compared separate clinical database diverse neoplasms perform Wilcoxon sum test comparisons. Benjamin-Hochberg corrected p-values are reported....
<p>Supplementary Figures</p>
<div>AbstractPurpose:<p>High-grade serous ovarian carcinoma (HGSOC) typically remains undiagnosed until advanced stages when peritoneal dissemination has already occurred. Here, we sought to identify HGSOC-specific alterations in DNA methylation and assess their potential provide sensitive specific detection of HGSOC at its earliest stages.</p>Experimental Design:<p>MethylationEPIC genome-wide analysis was performed on a discovery cohort comprising 23 HGSOC, 37...
<div>AbstractPurpose:<p>High-grade serous ovarian carcinoma (HGSOC) typically remains undiagnosed until advanced stages when peritoneal dissemination has already occurred. Here, we sought to identify HGSOC-specific alterations in DNA methylation and assess their potential provide sensitive specific detection of HGSOC at its earliest stages.</p>Experimental Design:<p>MethylationEPIC genome-wide analysis was performed on a discovery cohort comprising 23 HGSOC, 37...