A5022347703- Uterine Myomas and Treatments
- Endometriosis Research and Treatment
- Gynecological conditions and treatments
- Ovarian function and disorders
- Reproductive Biology and Fertility
- Reproductive System and Pregnancy
- Assisted Reproductive Technology and Twin Pregnancy
- Prenatal Screening and Diagnostics
- Tea Polyphenols and Effects
- Hemostasis and retained surgical items
- Reproductive Health and Contraception
- Menstrual Health and Disorders
- LGBTQ Health, Identity, and Policy
- Sperm and Testicular Function
- Organ and Tissue Transplantation Research
- Medical and Agricultural Research Studies
- Ovarian cancer diagnosis and treatment
- Cancer Risks and Factors
- Pregnancy and preeclampsia studies
- Reproductive Health and Technologies
- Marriage and Sexual Relationships
- Female Genital Mutilation/Cutting Issues
- Intestinal and Peritoneal Adhesions
- Digital Imaging in Medicine
- Menopause: Health Impacts and Treatments
Johns Hopkins University
2019-2025
Johns Hopkins Medicine
2019-2025
Johns Hopkins Hospital
2021
Southampton City Council
2020
RELX Group (United States)
2020
Kasturba Medical College, Manipal
2011-2012
Kasturba Medical College, Mangalore
2011
Western University
1994
A similar abstract of the interim analysis was previously published in Fertility and Sterility. EPIGALLOCATECHIN GALLATE (EGCG) FOR TREATMENT OF UNEXPLAINED INFERTILITY ASSOCIATED WITH UTERINE FIBROIDS (PRE-FRIEND TRIAL): EARLY SAFETY ASSESSMENT. Uterine fibroids are most common cause unexplained infertility reproductive-aged women. Epigallocatechin gallate (EGCG), a green tea catechin, has demonstrated its ability to shrink uterine prior preclinical clinical studies. Hence, we developed an...
Background Uterine fibroids are highly prevalent, collagen-rich, mechanically stiff, fibrotic tumors for which new therapeutic options needed. Increased extracellular matrix (ECM) stiffness activates mechanical signaling and Hippo/YAP promoting fibroid growth, but no prior studies have tested either as a target. We the hypothesis that injection of purified form collagenase Clostridium histolyticum (CCH) selectively digests type I III collagens would alter ECM stiffness, Hippo signaling,...
To determine whether in vitro fertilization (IVF) with preimplantation genetic testing for aneuploidy (PGT-A) is cost effective to achieve a live birth compared IVF alone fresh donor oocyte cycles.
ABSTRACT Previous epidemiological studies have suggested that green tea catechins, including Epigallocatechin‐3‐gallate (EGCG), the most abundant polyphenol in tea, may be associated with reduced serum folate levels. This is of particular interest as women childbearing age consuming EGCG from dietary supplements, or involved active clinical trials studying extract. was reported to shrink uterine fibroids preclinical and studies. observation led development a multicenter NICHD‐funded trial...
Absctract Context In vitro and in vivo evidence has supported the role of angiotensin II blockade reducing leiomyoma cell proliferation growth. However, no population-based study to date investigated this potential association. Objective This work aims determine whether prior angiotensin-converting enzyme inhibitor (ACEi) use is associated with a reduced odds development. Design A nested case-control was conducted. Setting The population assembled from Truven Health MarketScan Research...
Introduction Uterine fibroids affect 30%–77% of reproductive-age women and are a significant cause infertility. Surgical myomectomies can restore fertility, but they often have limited temporary benefits, with postoperative complications such as adhesions negatively impacting fertility. Existing medical therapies, oral contraceptives, gonadotropin hormone-releasing hormone (GnRH) analogues GnRH antagonists, manage fibroid symptoms not fertility friendly. This study addresses the pressing...
INTRODUCTION: Period poverty refers to the lack of access menstrual products. The “luxury tax” collected on products in majority United States is a major contributor period and barrier reproductive health for estimated 16.9 million women living U.S. In this study, we sought determine financial, social, political impact product tax age METHODS: cost sales sample (Playtex Sport Tampons, Regular & Super Multi Pack, Unscented – 50 Count) was compared when purchased through online retailers...
Abstract Background Randomized trials of assisted reproductive technology (ART) have been designed for outcomes clinical pregnancy or live birth and not powered obstetric such as preeclampsia, critical maternal fetal health. ART increasingly involves frozen embryo transfer (FET). Although there are advantages FET, multiple studies shown that risk preeclampsia is increased with FET compared fresh transfer, the reason this difference clear. NatPro will compare proportion between two commonly...
Abstract Uterine fibroids feature excessive deposition of types I and III collagen. Previous ex vivo studies showed an FDA-approved collagenase (EN3835)-digested collagen fibers in fibroid tissues; however, had not been evaluated for effects on uterine fibroids. The objective was to assess the safety tolerability injection directly into This a prospective, open label, dose escalation study. study participants were fifteen women aged 35–50 years with symptomatic planning undergo hysterectomy....