A5050819532- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Cervical Cancer and HPV Research
- Uterine Myomas and Treatments
- Endometriosis Research and Treatment
- Gynecological conditions and treatments
- Management of metastatic bone disease
- PARP inhibition in cancer therapy
- Cancer Cells and Metastasis
- Reproductive tract infections research
- COVID-19 and healthcare impacts
- Genital Health and Disease
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Sarcoma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Cancer Risks and Factors
- Estrogen and related hormone effects
- Cancer Diagnosis and Treatment
- Diversity and Career in Medicine
- Cancer survivorship and care
- Intraperitoneal and Appendiceal Malignancies
- Metabolism, Diabetes, and Cancer
- Lymphoma Diagnosis and Treatment
- Surgical site infection prevention
Long Island Jewish Medical Center
2021-2025
Northwell Health
2019-2025
Feinstein Institute for Medical Research
2020-2025
Jewish Hospital
2024
North Shore Diabetes and Endocrine Associates
2024
Hofstra University
2017-2023
Institute for Molecular Medicine
2023
Penn Center for AIDS Research
2022
University of Pennsylvania Health System
2022
Donald & Barbara Zucker School of Medicine at Hofstra/Northwell
2022
Endometrial cancer is the most common gynecologic malignancy in United States and one of few malignancies that had an increasing incidence mortality rate over last 10 years. Current research models fail to recapitulate actual characteristics tumor are necessary for proper understanding treatment this heterogenous disease. Patient-derived organoids provide a durable versatile culture system can capture patient-specific such as mutational profile response therapy primary tumor. Here we...
Metastatic adenocarcinoma to the vulva is a rare phenomenon, with few cases reported in literature. Here we discuss 64-year-old woman history of colorectal presenting vulvar metastasis. Clinical information was gathered via review electronic medical record. IHC useful diagnosis unusual metastases. In this case, staining for CDx2, CK20, PAX8, and CK7 helpful distinguishing gynecologic versus gastrointestinal primary. Our case highlights importance an accurate timely metastases patients...
715 Background: TAPUR is a phase II basket study evaluating antitumor activity of commercially available targeted agents in pts with advanced cancers genomic alterations. Results from cohort PC BRCA1/2 mut treated N+I are reported. Methods: Eligible had measurable disease, ECOG performance status (PS) 0-2, adequate organ function, and no standard treatment (tx) options or prior immune checkpoint inhibitor tx. PD-L1 expression testing was not required. Genomic performed CLIA-certified,...
To evaluate the safety and survival in women treated with adjuvant pelvic radiation "sandwiched" between six cycles of paclitaxel carboplatin chemotherapy completely resected UPSC.Surgically staged UPSC (FIGO stage 1-4) no visible residual disease were enrolled. Treatment involved (175 mg/m(2)) (AUC=6.0-7.5) every 21 days for 3 doses, followed by therapy (RT), an additional (AUC=5-6). Survival analysis, using Kaplan-Meier methods, was performed on patients who completed at least RT.A total...
We have developed and evaluated a next-generation bisulfite sequencing (NGS) assay to distinguish HPV16 cervical precancer (CIN2-3; N=59) from HPV16-positive transient infections (N=40). Cervical DNA was isolated treated with methylation quantified by (i) amplification barcoded primers massively parallel single molecule (ii) site-specific pyrosequencing. Assays were for agreement using intraclass correlation coefficients (ICC). Odds ratios (OR) high vs. low calculated. Single site...
Endometriosis is associated with increased rates of ovarian, particularly clear cell, adenocarcinomas. Malignant transformation ovarian endometriosis most common but rare cases have been reported in the bladder, abdominal wall, diaphragm, and rectum. We present case a 44-year-old female vesical cell adenocarcinoma arising background absence other pelvic endometriosis. The malignancy was diagnosed on transurethral resection bladder tumor managed radical surgery. Histology immunohistochemical...
To characterize the microbiota of postmenopausal women undergoing hysterectomy for endometrioid (EAC) or uterine serous cancers (USC) compared to controls with non-malignant conditions.
Objective Although preclinical studies suggest possible antitumor effects of metformin against cervical cancer, there is currently a lack clinical data examining the association use and survival in women with cancer. The aim this study was to examine cancer who were receiving metformin. Methods This retrospective consecutive cases stages I IV between 2000 2014. Patient demographics, medication use, tumor characteristics, treatment patterns, outcomes correlated use. Results There 70 (8.9%;...
•Two cases of large cervical mullerian adenosarcoma with sarcomatous overgrowth or heterologous elements and contrasting survival outcomes are reported.•When the diagnosis is uncertain suspected, review pathology by a national expert may be considered.•Rhabdomyoblastic differentiation more aggressive histologic type.
In Brief Background. Pseudoepitheliomatous hyperplasia (PEH) clinically and histologically mimics squamous cell carcinoma (SCC), specifically in patients with HIV AIDS. Case. A 51-year-old G3P2 AIDS history of vulvar cancer presented large bilateral exophytic lesions on the vulva, grossly appearing neoplastic. Initial biopsies were interpreted as SCC. After resolution empiric treatment acyclovir for possible herpes simplex virus type 2 outbreak, additional slides reviewed, cells viral...
Gynecologic cancer survivors report sexual health among their highest concerns. The aim of this study was to identify the prevalence dysfunction (SD) in gynecologic malignancies and evaluate association function with race, ethnicity treatment modality. In study, endometrial, cervical, vaginal, vulvar who presented oncology practice were asked self-administer Female Sexual Function Index (FSFI) survey function. SD estimated its demographic clinical co-variates analyzed. Of 155 participants,...
Disparities in endometrial cancer has increased during the past decade with Black women more likely to be diagnosed at a later stage and have higher mortality. The majority of research been focused on cultural barriers, socioeconomic status, lack access care, comorbidities, tumor histology explain these disparities. Limited studies conducted disparity treatment intraepithelial neoplasia(EIN). We sought analyze differences used management postmenopausal EIN evaluate whether race/ethnicity is...
Numerous reports document elevated cancer rates among children living near nuclear facilities in various nations. Little research has examined U.S. the nation's 103 operating reactors. This study determined that incidence for < 10 yr of age who live within 30 mi (48 km) each 14 plants eastern United States (49 counties with a population > 16.8 million) exceeds national average. The excess 12.4% risk suggests 1 9 cancers reside reactors is linked to radioactive emissions. If 5 western states...
To examine association of lympho-vascular space invasion (LVSI) with clinico-pathological factors and to evaluate survival women low-grade serous ovarian carcinoma containing areas LVSI.This is a multicenter retrospective study examining consecutive cases surgically treated stage I-IV (n = 178). Archived histopathology slides for the tumors were reviewed, LVSI was scored as present or absent. status correlated findings outcome.LVSI seen in 79 (44.4%, 95% confidence interval [CI] 37.1-51.7)....
Invasive cervix cancer (ICC) is the third most common malignant tumor in women and human papillomavirus 16 (HPV16) causes more than 50% of ICC. DNA methylation a covalent modification predominantly occurring at CpG dinucleotides increased across HPV16 genome strongly associated with ICC development. Next generation (Next Gen) sequencing has been proposed as novel approach to determine methylation. However, utilization this method survey not well described. Moreover, it provides additional...