A5042763588- Bacteriophages and microbial interactions
- Virus-based gene therapy research
- Cancer Research and Treatments
- Orthopedic Infections and Treatments
- Bacterial Infections and Vaccines
- Nanoplatforms for cancer theranostics
- Infective Endocarditis Diagnosis and Management
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Viral gastroenteritis research and epidemiology
- Immunotherapy and Immune Responses
- Respiratory viral infections research
- Plant Virus Research Studies
- Animal Virus Infections Studies
- Transgenic Plants and Applications
- Microbial Metabolic Engineering and Bioproduction
- Influenza Virus Research Studies
- Electron Spin Resonance Studies
- Cellular transport and secretion
- Escherichia coli research studies
- Immune Response and Inflammation
- Magnetism in coordination complexes
- Lanthanide and Transition Metal Complexes
- RNA modifications and cancer
- Dendrimers and Hyperbranched Polymers
The University of Texas at Dallas
2020-2025
Advanced Imaging Research (United States)
2024
The University of Texas Southwestern Medical Center
2024
Vaccines have saved countless lives by preventing and even irradicating infectious diseases. Commonly used subunit vaccines comprising one or multiple recombinant proteins isolated from a pathogen demonstrate better safety profile than live attenuated vaccines. However, the immunogenicity of these is weak, therefore, require series doses to achieve sufficient immunity against pathogen. Here, we show that biomimetic mineralization inert model antigen, ovalbumin (OVA), in zeolitic imidazolate...
Supramolecular/macromolecular organic radical contrast agents (smORCAs) overcome many of the limitations nitroxide radicals for use in magnetic resonance imaging <italic>in vivo</italic> like poor stability and weak contrast.
Tobacco mosaic virus conjugated to TEMPO creates a new magnetic resonance imaging agent that detects superoxide produced in inflamed liver conditions.
Intracellular bacterial infections are difficult to diagnose and treat because the host cells shelter bacteria from molecular recognition by imaging agents, antibiotics, immune system. This problem arises...
To overcome the challenge of lysosomal degradation material in cells, we developed a carrier using chemical synthesis to successfully bypass endosomal trap and deliver therapeutic materials directly into cytoplasm cells.
Virus-like particles are an emerging class of nano-biotechnology with the Tobacco Mosaic Virus (TMV) having found a wide range applications in imaging, drug delivery, and vaccine development. TMV is typically produced planta, and, as RNA virus, highly susceptible to natural mutation that may impact its properties. Over course 2 years, from 2018 until 2020, our laboratory followed spontaneous point coat protein-first observed 30 Da difference electrospray ionization mass spectrometry...
Vaccines have saved countless lives by preventing and even irradicating infectious diseases. Commonly used subunit vaccines comprising one or multiple recombinant proteins isolated from a pathogen demonstrate better safety profile than live attenuated vaccines. However, the immunogenicity of these is weak, therefore, require series doses to achieve sufficient immunity against pathogen. Here, we show that biomimetic mineralization inert model antigen, ovalbumin (OVA), in zeolitic imidazolate...
ABSTRACT: Vaccines have saved countless lives by preventing and even irradicating infectious dis-eases. Commonly used subunit vaccines comprising one or multiple recombinant proteins isolated from a pathogen demonstrate better safety profile than live attenuated vaccines. However, the immuno-genicity of these is weak, therefore, require series doses to achieve sufficient immunity against pathogen. Here, we show that biomimetic mineralization inert model antigen, ovalbumin (OVA), in zeolitic...
Intracellular bacterial infections are difficult to diagnose and treat because the host cells shelter bacteria from molecular recognition by imaging agents, antibiotics, immune system. This problem arises when bladder epithelial infected uropathogenic Escherichia coli (UPEC)—one of causative agents urinary tract infection (UTI). UTIs among most common a worldwide health concern. It is challenging design probes for intracellular UPEC or targeted antibiotic treatment probe must possess...
S-adenosyl-L-methionine (SAM) is an abundant biomolecule used by methyltransferases to regulate a wide range of essential cellular processes such as gene expression, cell signaling, protein functions, etc. Despite considerable effort, there remain many specificity challenges associated with designing small molecule inhibitors for methyltransferases, most which exhibit off-target effects. Interestingly, NMR evidence suggests that SAM undergoes conformeric exchange between several states when...
Nanoparticle-based therapeutics have been applied in a broad range of clinical and pre-clinical applications from diagnosis to treatment for cancer. A wide synthetic naturally occurring materials such as polymers, metal oxides, silicate, liposomes, carbon nanotubes developed overcome key barriers small molecule including intracellular trafficking, cell/tissue targeting, poor biodistribution, low efficiency. Virus like particles (VLPs)—engineered non-infectious self-assembling systems based...
Intracellular targeting is an important aspect of the efficient delivery drugs and nanotherapeutics. Cytosolic transport nanomaterials often essential requirement for therapeutic into cells but remains a challenge owing to endosomal trap eventual lysosomal degradation cargo. To address this, we designed functional carrier that escapes endosome delivers biological materials cell's cytoplasm. For this purpose, synthesized glutathione-sensitive linker connects well-known mitochondria lipophilic...
Abstract Virus-like particles are an emerging class of nano-biotechnology with the Tobacco Mosaic Virus (TMV) having found a wide range applications in imaging, drug delivery, and vaccine development. TMV is typically produced planta , and, as RNA virus, highly susceptible to natural mutation that may impact its properties. Over course two years, from 2018 until 2020, our laboratory followed spontaneous point coat protein—first observed 30 Da difference electrospray ionization mass...