A5081129778- HIV/AIDS Research and Interventions
- HIV, Drug Use, Sexual Risk
- HIV Research and Treatment
- Sex work and related issues
- HIV/AIDS drug development and treatment
- Migration, Health and Trauma
- Pneumocystis jirovecii pneumonia detection and treatment
- Cannabis and Cannabinoid Research
- Hepatitis B Virus Studies
- Homelessness and Social Issues
- Substance Abuse Treatment and Outcomes
- Global Maternal and Child Health
- Reproductive tract infections research
- Hepatitis C virus research
- Legionella and Acanthamoeba research
- Prenatal Substance Exposure Effects
- Ocular Surface and Contact Lens
- Bipolar Disorder and Treatment
- Ocular Infections and Treatments
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Healthcare Systems and Challenges
- Cellular transport and secretion
- Pelvic floor disorders treatments
- Energy and Environment Impacts
Albert Einstein College of Medicine
2017-2025
Montefiore Medical Center
2017-2024
Yeshiva University
2021-2023
Montefiore Health System
2020-2023
Creative Commons
2021
Rwanda Military Hospital
2020-2021
University of Rwanda
2021
General Department of Preventive Medicine
2021
Republic of Burundi
2020
Rutgers, The State University of New Jersey
2020
Dendritic spines receive most excitatory inputs in the CNS and compartmentalize calcium. Although mechanisms of calcium influx into have been explored, it is unknown what determines decay kinetics spines. With two-photon microscopy we investigate action potential-induced dynamics from rat CA1 pyramidal neurons slices. The [Ca 2+ ] i shows two kinetics: an initial fast component, during which decays to dendritic levels, followed by a slower phase spine follows kinetics. correlation between...
Parsa Erfani, BA; Nishant Uppal, BS; Caroline H. Lee, Ranit Mishori, MD, MHS; Katherine R. Peeler, MD
An alternative pathway of Trp metabolism involves the conversion to kynurenine by indoleamine-2,3-dioxygenase, which leads synthesis neurotoxin, quinolinic acid. This study explores relationship indoleamine-2,3-dioxygenase activity with stages HIV infection. Sera from 206 HIV-positive and 72 seronegative subjects were analyzed for kynurenine. The kynurenine-to-Trp (KT) ratio was calculated. mean KT controls 36.6 +/- 10.9, median 34.9. upper limit ratio, defined as + 2 SD, 58.4. Patients...
To identify modifiable risk factors contributing to Acanthamoeba keratitis (AK) infection.A case-control investigation was conducted. Case patients were soft contact lens wearers with laboratory-confirmed AK. Control ≥12 years of age, no history recruited from 14 ophthalmology referral centers and a clinical laboratory. matched on state residence type primary eye care provider (ophthalmologist or optometrist). Participants interviewed using standardized questionnaire. Univariable...
Introduction Pre-exposure Prophylaxis (PrEP) is a daily pill aimed at reducing HIV transmission risk when taken as prescribed. It’s highly recommended for high-risk Men who have sex with (MSM). This study to assess PrEP awareness and willingness use it among Rwandan MSM, critical aspect given PrEP’s proven effectiveness. The findings are expected inform policy decisions further advance the implementation of strategies. Methods cross-sectional design that utilized web-based survey conducted...
Abstract: HIV incidence is increasing among Latino/a/x individuals in the United States, especially young Latino/x gay, bisexual, and sexual minority men. populations face heightened structural social barriers to effective interventions for prevention, including pre-exposure prophylaxis, across care continuum. Implementation science provides a timely methodology developing, testing, scaling into practice. considers specific population's priorities environment, which relevant given diversity...
Background: Community-engaged research (CEnR) is fundamental to effective HIV prevention and treatment implementation, although limited in practice. We describe CEnR lessons learned by researchers HIV-related implementation science improve future CEnR. Setting: Academic-community partnerships funded the 2019–2021 National Institutes of Health Ending Epidemic (EHE) supplement awards. Methods: Seven individual awardees representing 8 EHE awards documented partnership characteristics key...
Aim: To share insights on Implementation Science (IS) methods, challenges, solutions, and best practices derived from the second National Meeting for Research Community Collaboration toward “Ending HIV Epidemic (EHE) in United States.” Methods: This 2022 hybrid, one-day conference featured presentations 13 projects funded as NIH supplements to CFARs ARCs between 2019 2022. Selected their robust findings, were grouped into four topics: (1) community-based outreach strategies, (2) taking...
<h3>Background</h3> Few if any studies of the association between pulmonary tuberculosis (TB) and lung function loss have had access to premorbid values. <h3>Methods</h3> Using a retrospective cohort design, study recruited employed South African gold miners who undergone test (PFT) January 1995 August 1996. The 'exposed' group comprised 185 treated for TB after initial PFT 'unexposed' age-matched without TB. All participants follow-up April June 2000. outcome interest was decline in during...
The aim was to describe a geographically and clinically diverse sample of cases Acanthamoeba keratitis (AK) establish the risk factors for poor outcomes among patients with this disease.We conducted retrospective, population-based case series 116 AK identified through national surveillance network. Data were collected via medical record review by diagnosing ophthalmologists phone interviews patients. Exact logistic regression modeling used determine visual outcomes.Among data available on...
Abstract Background ‘Treat All’ policies recommending immediate antiretroviral therapy (ART) soon after HIV diagnosis for all people living with (PLHIV) are now ubiquitous in sub-Saharan Africa. While early ART initiation and retention is effective at curtailing disease progression transmission, evidence suggests that stigma may act as a barrier to engagement care. This study sought understand the relationships between care PLHIV Rwanda context of Treat All. Methods Between September 2018...
Latinx sexual minority men (LSMM) face multilevel barriers to accessing HIV pre-exposure prophylaxis (PrEP). To address these barriers, we designed and implemented community-based organization (CBO)-PrEP, a collaborative telehealth PrEP program for LSMM. We this delivery through process involving staff from local CBOs primary care-based prevention program. Staff met weekly over 3-month period establish protocols referrals, obtaining insurance coverage, navigation appointments laboratory...
Abstract The von Hippel-Lindau (VHL) gene is the major renal cancer in adults. mechanism of tumor suppression by VHL protein only partly elucidated. loss increases expression hypoxia-inducible factor α transcription factors. However, clinical and biochemical data indicate that factors are necessary but not sufficient for tumorigenesis, which suggests other effector pathways involved. Jade-1 interacts strongly with most highly expressed proximal tubules, precursor cells cancer. Short-lived...
Aiming to reach UNAIDS 90-90-90 targets, nearly all sub-Saharan African countries have expanded antiretroviral therapy (ART) people living with HIV (PLWH) (Treat All). Few published data exist on viral load testing and suppression under Treat All in this region. We assessed proportions of patients available test results who were virally suppressed, as well factors associated suppression, among PLWH 10 Rwandan health centres after implementation.Cross-sectional study during 2018 adults (≥15...
Introduction HIV treatment guidelines recommend that all people living with (PLWH) initiate antiretroviral therapy (ART) as soon possible after diagnosis (Treat All). As Treat All is more widely implemented, an increasing proportion of PLWH are likely to ART when they asymptomatic, and may view the relative benefits risks differently than those initiating at advanced disease stages. To date, patient perspectives care under in sub-Saharan Africa have not been well described. Methods From...
Nearly all countries in sub-Saharan Africa have adopted policies to provide antiretroviral therapy (ART) persons living with HIV (Treat All), though care outcomes of these programmes are not well-described. We estimated changes ART initiation and retention following Treat All implementation Rwanda July 2016.We conducted an interrupted time series analysis adults enrolling at ten Rwandan health centres from 2014 September 2017. Using segmented linear regression, we assessed levels trends...
Treat-All guidelines recommend initiation of antiretroviral therapy (ART) for all people with HIV (PWH) on the day diagnosis when possible, yet uncertainty exists about impact same-day ART subsequent care engagement. We examined association loss to follow-up and viral suppression among patients in 11 sub-Saharan African countries.
In the United States, undocumented African immigrants living with HIV enter care late, potentially leading to adverse individual and population health outcomes, yet little is known about specific experiences of diagnosis linkage among this population. We conducted individual, semi-structured interviews adults who were in New York City. Interviews explored perspectives regarding social, institutional, societal barriers facilitators testing care. Of 14 participants from 9 different countries,...
In India and other low-and-middle-income countries, little is known about how intersectional stigma affects MSM engagement in ART. Informed by the Health Stigma Discrimination Framework, we qualitatively examined multiple stigmas influence ART among Indian MSM. We conducted 3 focus groups (N = 22) with living HIV, aged 21–58 years, Delhi Hyderabad to identify potential intervention targets solutions improve treatment outcomes. Framework analysis techniques were used code analyze translated...