A5053580185- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Neurobiology of Language and Bilingualism
- Older Adults Driving Studies
- Amyotrophic Lateral Sclerosis Research
- Parkinson's Disease Mechanisms and Treatments
- Memory and Neural Mechanisms
- Neurological diseases and metabolism
- Text Readability and Simplification
- Epilepsy research and treatment
- Advanced MRI Techniques and Applications
- Urban Transport and Accessibility
- Telemedicine and Telehealth Implementation
- Health, Environment, Cognitive Aging
- Advanced Neuroimaging Techniques and Applications
- Cholinesterase and Neurodegenerative Diseases
- Brain Tumor Detection and Classification
- Health and Well-being Studies
- Personality Traits and Psychology
- Diet and metabolism studies
- Cognitive Functions and Memory
- Cerebrovascular and genetic disorders
- Music Therapy and Health
- Spatial Neglect and Hemispheric Dysfunction
Eginition Hospital
2021-2024
National and Kapodistrian University of Athens
2015-2024
Athens Medical Center
2015-2023
University General Hospital Attikon
2019-2022
Nia Association
2022
ID Genomics (United States)
2022
University of the Third Age
2021
Base Training
2017-2020
The University of Sydney
2019
Democritus University of Thrace
2019
Background The novel coronavirus disease (COVID-19) was first detected in Mainland China December 2019, and soon it spread throughout the world, with multiple physical psychological consequences across affected populations. Aims aim of current study to analyze impact COVID-19 pandemic on older adults mild cognitive impairment (MCI)/dementia their caregivers as well. Materials Methods Two hundred four took part study, completing a self-reported questionnaire about person MCI/dementia own,...
Physical as well cognitive training interventions improve specific functions but effects barely generalize on global cognition. Combined physical and may overcome this shortcoming facilitate the neuroplastic potential which, in turn, be guided by training. This study aimed at investigating benefits of combined cognition while assessing effect dosage exploring role several modifiers. In multi-center study, 322 older adults with or without neurocognitive disorders were allocated to a...
Neurodegeneration in Alzheimer's disease (AD) is closely associated with the accumulation of pathologic tau aggregates form neurofibrillary tangles. We found that a p.Asp395Gly mutation VCP (valosin-containing protein) was dementia characterized neuropathologically by neuronal vacuoles and Moreover, appeared to exhibit disaggregase activity vitro, which impaired mutation. Additionally, intracerebral microinjection led increased mice knocked in, as compared injected wild-type mice. These...
One major challenge during the COVID-19 pandemic was limited accessibility to healthcare facilities, especially for older population. The aim of current study exploration extent which systems responded needs people with or without cognitive impairment and their caregivers in Adrion/Ionian region. Data were collected through e-questionnaires regarding adequacy system anonymously administered individuals stakeholder providers following countries: Slovenia, Italy (Calabria), Croatia, Bosnia...
Patients with neurodegenerative disease show distinct patterns of personality change, some which may be traced to focal neurological damage, whereas others mediated by cultural reactions functional impairment. Although such changes are early and pervasive in behavioral variant frontotemporal dementia (bvFTD), milder seen Alzheimer (AD), no study has examined all Big 5 factors mild cognitive impairment (MCI) patients. In addition, the influence culture ethnicity on disease-related seldom been...
Early diagnosis of Alzheimer's disease (AD) based on clinical criteria alone may be problematic, while current and future treatments should administered earlier in order to more effective. Thus, various biomarkers could used for early detection AD. We evaluated brain perfusion with 99mTc-HMPAO single photon emission computed tomography (SPECT) Brodmann areas (BAs) mapping mild AD using an automated software (NeuroGam) the semi-quantitative evaluation BAs comparison software's normal...
Despite the known validity of clinical diagnostic criteria, significant overlap symptoms between Frontotemporal dementia (FTD) subtypes exists in several cases, resulting great uncertainty boundaries. We evaluated perfusion FTD using brain 99mTc-HMPAO SPECT with Brodmann areas (BA) mapping. NeuroGamTM software was applied on single photon emission computed tomographic (SPECT) studies for semi-quantitative evaluation BA and comparison software's normal database. studied 91 consecutive...
Patients with movement disorders such as Parkinson’s disease (PD) living in remote and underserved areas often have limited access to specialized healthcare, while the feasibility reliability of video-based examination remains unclear. The aim this narrative review is examine which parts neurological assessment are feasible reliable disorders. Clinical studies demonstrated that most feasible, even absence a third party, including stance gait—if an assistive device not required—bradykinesia,...
Cross-cultural studies of neurodegenerative disorders are especially important when the disease in question is difficult to diagnose, particularly if symptoms illness include behavioral disturbances that may be interpreted differently different cultures. One such frontotemporal lobar degeneration (FTLD), an early-age-of-onset dementia disproportionately affects social behavior. We report demographic and neuropsychologic characteristics more than 300 patients diagnosed with FTLD United...
The definite diagnosis of Alzheimer's disease (AD) is based on the detection beta amyloid (Aβ) plaques and neurofibrillary tangles (NFTs) - which are pathological hallmarks disease- in postmortem brains. Although regional Cerebral Blood Flow (rCBF) Glucose Metabolism (CGM) abnormalities have already been studied AD patients with Single Photon Emission Computed Tomography (SPECT) Positron (PET), development specific imaging agents for direct mapping Aβ living brain, a great challenge. probes...
The aim of this study was to evaluate the contribution brain perfusion single-photon emission computed tomography (SPECT) studies with mapping Brodmann areas (BAs) in differential diagnosis between Alzheimer's disease (AD) and frontotemporal degeneration (FTLD) syndromes.Thirty-nine patients AD 73 FTLD syndromes [behavioural variant (bvFTLD); language (lvFTLD), including semantic dementia (SD) progressive nonfluent aphasia (PNFA); corticobasal (CBD)/progressive supranuclear palsy (PSP)...
Self-monitoring is a crucial component of human empathy and necessary for the formation repair social relations. Several studies have brought to light possible neuronal substrates associated with self-monitoring, but information that they provided inconclusive. The authors, therefore, studied large group patients dementia assess what brain structures are self-monitoring function.Methods: Seventy-seven various types were screened using voxel-based morphometry volume reduction in problems,...
The aim of this study was to assess the ability Neuropsychiatric Inventory (NPI) scale profiles differentiate between distinct frontotemporal dementia (FTD) subtypes.The NPI used 311 older patients who had been clinically diagnosed with FTD. FTD subtypes included behavioural variant (bvFTD, n = 121), primary progressive aphasia (semantic (n 69), non-fluent agrammatic 31), and logopenic 0)), FTD-motor neuron disease 4), supranuclear palsy 43), corticobasal syndrome 43). Total score scores for...
Objectives: Previous studies indicate a negative association between depression and driving fitness in the general population. Our goal was to cover gap literature explore link depressive symptoms behavior individuals with mild cognitive impairment (MCI) through use of simulator experiment.Methods: Twenty-four MCI (mean age = 67.42, SD 7.13) 23 cognitively healthy 65.13, 7.21) were introduced study. A valid license regular car served as main inclusion criteria. Data collection included...
Aberrant motor behaviour or wandering refers to aimless movement without a specific purpose. Wandering is common in patients with dementia and leads early institutionalization caregivers' burden. Non-pharmacological interventions should be also considered as first-line solution for the because current pharmacological treatment has serious side-effects.A cross-over randomised controlled trial (RCT) 60 participants of all stages different types was conducted Greece. The sample randomly...
Frontotemporal degeneration (FTD), one of the most prevalent causes presenile dementia, includes three subtypes: (1) behavioral variant FTD (bvFTD), (2) semantic (SV), and (3) progressive nonfluent aphasia (PNFA). Corticobasal degeneration, supranuclear palsy, FTD-ALS are linked clinically pathologically to FTD. The clinical presentation these FTD-related disorders comprises a wide spectrum, including psychiatric symptoms, aphasia, motor neuron findings, parkinsonism. Two types...
There is a growing body of research on language impairment in bilingual speakers with neurodegenerative diseases. Evidence as to which better preserved rather inconclusive. Various factors seem influence performance, most notably age acquisition, level proficiency, immersion and degree exposure each language. The present study examined fluency, lexical, discourse grammatical abilities Greek-French late man the non-fluent/agrammatic variant primary progressive aphasia (nfvPPA). Speech samples...
Introduction. Brain perfusion studies with single-photon emission computed tomography (SPECT) have been applied in demented patients to provide better discrimination between frontotemporal dementia (FTD) and Alzheimer's disease (AD). Aim. To assess the of specific Brodmann (Br) areas brain cortex FTD AD patients, using NeuroGam processing program 3D voxel-by-voxel cerebral SPECT analysis. Material methods. We studied 34 consecutive patients. used established criteria for diagnosis AD. All...