About
Contact & Profiles
A5071865537
Research Areas
- Alzheimer's disease research and treatments
- Neurological diseases and metabolism
- Endoplasmic Reticulum Stress and Disease
University of Pennsylvania
2020
Neurodegeneration in Alzheimer's disease (AD) is closely associated with the accumulation of pathologic tau aggregates form neurofibrillary tangles. We found that a p.Asp395Gly mutation VCP (valosin-containing protein) was dementia characterized neuropathologically by neuronal vacuoles and Moreover, appeared to exhibit disaggregase activity vitro, which impaired mutation. Additionally, intracerebral microinjection led increased mice knocked in, as compared injected wild-type mice. These...
10.1126/science.aay8826
article
EN
Science
2020-10-01
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