A5074979337- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Neurogenetic and Muscular Disorders Research
- Parkinson's Disease Mechanisms and Treatments
- RNA Research and Splicing
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological diseases and metabolism
- Nuclear Structure and Function
- Advanced Neuroimaging Techniques and Applications
- Endoplasmic Reticulum Stress and Disease
- Air Quality and Health Impacts
University of Pennsylvania
2020-2024
Institute on Aging
2024
Neurodegeneration in Alzheimer's disease (AD) is closely associated with the accumulation of pathologic tau aggregates form neurofibrillary tangles. We found that a p.Asp395Gly mutation VCP (valosin-containing protein) was dementia characterized neuropathologically by neuronal vacuoles and Moreover, appeared to exhibit disaggregase activity vitro, which impaired mutation. Additionally, intracerebral microinjection led increased mice knocked in, as compared injected wild-type mice. These...
Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are neuropathologic subtypes of frontotemporal lobar with tau inclusions (FTLD-tau), primary tauopathies in which intracellular aggregation contributes to neurodegeneration. Gosuranemab (BIIB092) is a humanized monoclonal antibody that binds N-terminal tau. While passive immunotherapy trials for PSP failed demonstrate clinical benefit, reduced the cerebrospinal fluid transgenic mouse models patients. However, sequelae...
Abstract Background Exposure to fine particulate matter air pollution (PM 2.5 increases risk for dementia. However, it is unknown whether this relationship mediated by dementia-related neuropathologic change found at autopsy. We aimed examine relationships between PM exposure, dementia severity, and dementia-associated change. Methods This cross-sectional study used harmonized demographic, clinical, genetic, neuropathological data from autopsy cases collected 1998 2022 the Center...